Hydrocortisone added during stress in people on low-dose prednisolone
Treatments studied
Part of Bones, joints & muscles, Brain & nervous system, Heart & circulation, Hormones & metabolism, Immune system & allergy, Skin clinical trials.
This study tests whether adding supplemental hydrocortisone during stressful events can prevent problems in people who develop adrenal insufficiency from long-term prednisolone. It is meant to see if “stress dosing” is safer and helps the body respond to stress.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 50 or older
- You are a postmenopausal woman (a hormone blood test like FSH may be checked)
- You have been diagnosed with PMR, GCA, or both
- You have taken prednisolone for at least 12 weeks, and you are currently on 0–5 mg daily
- You have been on a dose of 5 mg per day or less for at least 2 weeks before screening
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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