Spironolactone for anemia in children on dialysis
Treatments studied
Part of Blood & lymphatic, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests whether a medicine called spironolactone can help children on hemodialysis who still have anemia despite usual treatment. It aims to see if this drug improves red blood cell production better than standard care alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 6 and 18 years old and weigh between 25 and 50 kg.
- You have been on regular hemodialysis (3 times a week) for at least 6 months.
- Your potassium level is below 5.5 mmol/L and you still make urine.
- You have anemia (hemoglobin between 9.5 and 12.5 g/dL) and low iron stores (TSAT below 20%).
- You have been on a stable dose of erythropoietin (EPO) for at least 8 weeks.
- You are not scheduled for a kidney transplant within the next 6 weeks and do not have severe liver disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a drug called luspatercept to see if it can raise hemoglobin levels in people with anemia caused by chronic kidney disease. It's for those whose current treatments aren't working well or who cannot use them.
This study tests the drug spironolactone, a medicine that helps your body balance fluids and potassium, in both HIV-positive and HIV-negative adults. The goal is to see how it affects a key protein complex in your cells. If you are HIV-positive, you need to have well-controlled HIV with undetectable virus levels and be on stable treatment.
This trial studies whether taking iron by mouth can improve iron levels and anemia (low red blood cell counts) in children with chronic kidney disease. It may help reduce fatigue and support normal blood-making, by comparing different approaches for children who meet specific iron test results.
This study tests whether a medication called erythropoietin (a hormone that helps your body make red blood cells) can improve hemoglobin levels in people on dialysis. It also looks at whether metabolic syndrome (a group of conditions like high blood pressure and high blood sugar) makes the medicine less effective.
This study tests whether spironolactone, a water pill that helps the heart and blood vessels, can improve symptoms in people with pulmonary arterial hypertension (PAH), a condition of high blood pressure in the lungs. It's a phase 2 trial, meaning it's early but may offer a new treatment option.
This trial tests if spironolactone can help children with autism who have a certain genetic change (in the NCOR gene). The study will monitor improvement and safety over time.
Hear when a new Anemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.