Closing the hole in the heart to prevent strokes
Part of Genetic & congenital, Heart & circulation clinical trials.
This trial tests a new device that sews shut a small hole in the heart (called a patent foramen ovale, or PFO). This hole may let tiny clots pass from the body to the brain, causing strokes or mini-strokes. If you have had a stroke or mini-stroke linked to this hole, this procedure might help prevent future events.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with a patent foramen ovale (PFO) – a small opening between the upper chambers of the heart.
- You have had a stroke or mini-stroke (TIA) that doctors believe is related to this hole, after ruling out other causes.
- The hole must allow a moderate or large amount of blood to pass from the right side of the heart to the left side (called a right-to-left shunt).
- You are willing to sign a consent form and attend follow-up visits as required.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial looks at whether closing a small hole in the heart (PFO) can reduce tiny clots traveling to the brain. It includes people who have had a stroke or migraine, and also those without symptoms but with high-risk features.
This trial compares two treatments for preventing another stroke in older adults who have a PFO (a small hole in the heart). It tests whether closing the hole with a device works better than using blood-thinning medication.
This trial tests a new device to close a PFO (a small hole between the upper chambers of the heart) in people who have had a stroke caused by a blood clot. The goal is to prevent future strokes by blocking the hole.
This trial looks at the safety and results of closing a PFO (a small hole in the heart) in people who have had a stroke or embolism with no other clear cause. If you qualify, doctors will close your PFO using a small tube inserted through a blood vessel and then follow your health over time.
This trial tests a device called the Snowy PFO Closure System, which is meant to close a small hole in the heart (PFO) that can let blood clots pass to the brain and cause strokes or migraines. The device is inserted through a small tube, and the study aims to see if it is safe and works well.
This trial tests a new device to close a PFO (a small hole in the heart) in people who have had a stroke caused by a blood clot passing through that hole. The goal is to see if the device can prevent another stroke.
Hear when a new Patent Foramen Ovale (PFO) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.