Clin2
NCT07735650Worth exploringEnrolling by invitation

Safe withdrawal of immune meds after liver transplant

Liver TransplantationLiver Transplantation in Long-term

Part of Immune system & allergy clinical trials.

This study tests whether long-term liver transplant recipients (5+ years after transplant) can safely stop or reduce their immunosuppressant medications by checking for donor cells (chimerism) in the liver. If you have stable liver function and agree to a liver biopsy, you may be able to join.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
60 people
Ages
20 years and older
Study type
Interventional

Who can take part

  • You had a liver transplant (from a living or deceased donor) at least 5 years ago.
  • Your liver function tests (blood tests) are stable and within normal limits.
  • You are at least 20 years old and feeling well enough to do daily activities (fully active or able to do light work).
  • You are willing to have a liver biopsy to check for donor cells in your liver.
  • No active infections, recent cancers, or signs of rejection in the past year.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07269041Recruiting· Phase 1/Phase 2
Immune tolerance after liver transplant

This trial tests a way to help your body accept your liver transplant without needing lifelong anti-rejection drugs. It uses your living donor's stem cells to train your immune system to not attack the new liver.

Los Angeles, California
NCT07739914Recruiting· Phase 3
Switching anti-rejection medicine after a liver transplant

This trial tests whether switching from a standard anti-rejection medicine to a different one (everolimus) about a year after a liver transplant can help protect your new liver with fewer side effects. If you qualify, you will be monitored closely for a few years to see how well the new medicine works for you.

Heidelberg, Baden-Wurttemberg
NCT07862439Not yet recruiting· Phase 2
Reducing immune-suppressing drugs in liver transplant patients

This study tests if some liver transplant patients can safely take lower doses of their immune-suppressing medicines, potentially reducing side effects. It uses a biomarker test to guide the treatment changes.

Philadelphia, Pennsylvania
NCT06147375Not yet recruiting
Stopping anti-rejection medicine after liver transplant in children

This study looks at whether it is safe to stop or reduce anti-rejection medicines in children who have had a liver transplant for at least 4 years and are doing well. The goal is to see if they can live without these medicines and their side effects.

Tianjin, Tianjin Municipality
NCT07634562Recruiting· Phase 1/Phase 2
Reducing immune-suppressing drugs after liver transplant

This study tests a new way to lower the amount of immune-suppressing medicine needed after a liver transplant. It uses special treatments before or during the transplant to help your body accept the new liver with fewer drugs, which may reduce side effects.

Stanford, California
NCT07549503Recruiting· Phase 2
Liver Transplant Immune Changes Study

This research study tracks early signs of immune system changes in children who received a liver transplant 3–7 years ago and are doing well. By studying blood and liver samples, researchers hope to better understand how to prevent rejection and improve long-term transplant survival.

San Francisco, California

Hear when a new Liver Transplantation trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.