Focused sound waves to open the blood-brain barrier for brain tumors
This early study tests a device that uses sound waves and tiny bubbles to safely open the blood-brain barrier, allowing treatment to reach brain tumors more effectively. It is for people with recurrent high-grade glioma or brain metastases that do not need immediate surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- Your brain tumor must be a recurrent high-grade glioma or a brain metastasis, and must not need urgent surgery.
- The tumor must be at least 25-30 mm long and in a part of the brain that is not critical for movement or speech.
- You must be able to sit still for the procedure and agree to have part of your head shaved.
- Your blood pressure and blood clotting must be within safe limits, and you must be able to have MRI and CT scans with contrast dye.
- If you are of childbearing potential, you must use effective birth control during and for 6 months after the procedure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1 study tests whether a device can safely and repeatedly open the blood-brain barrier (a protective shield in the brain) in children with malignant brain tumors. It aims to help the tumor treatment work better while watching for safety issues.
This trial tests a new treatment called sonodynamic therapy that uses sound waves and a special drug to target brain tumors that have come back. It aims to see if this approach is safe and can shrink tumors in people who are eligible for surgery.
This study looks at using focused ultrasound to temporarily loosen the brain’s “blood barrier” around certain brain tumors, while people still get standard surgery. It aims to help doctors learn how safe the approach is and collect blood/fluid samples during the operation.
This study tests whether focused ultrasound can safely open the protective barrier around the brain to help chemotherapy reach a rare type of brainstem tumor more effectively. You would receive standard chemotherapy and radiation first, then the ultrasound procedure followed by additional chemotherapy.
This trial tests whether focused ultrasound can safely open the blood-brain barrier to help your chemotherapy work better. It is for people with glioblastoma who have already completed standard surgery and chemo-radiation and are now on maintenance chemo.
This early-phase trial tests a tiny implanted device placed during brain tumor surgery. It delivers very small doses of medicine directly to the tumor area for a short time, aiming to see if this approach is safe and workable in patients with certain gliomas.
Hear when a new Brain Metastases From Extra-cranial Solid Tumors trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.