Safety study of repeated blood-brain barrier opening for pediatric brain tumors
Part of Brain & nervous system, Cancer clinical trials.
This Phase 1 study tests whether a device can safely and repeatedly open the blood-brain barrier (a protective shield in the brain) in children with malignant brain tumors. It aims to help the tumor treatment work better while watching for safety issues.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 5 and under 18 years old
- You need a malignant brain tumor above the brain “tent” (supra-tentorial) and the tumor must be back or growing after standard treatment
- Doctors plan to treat you with carboplatin as part of your care
- You must be able to get the ultrasound treatments (“sonications”) and MRI scans without needing sedation, if possible
- Your body must be healthy enough for treatment: enough blood counts (neutrophils and platelets) and organ tests in acceptable ranges
- You must not have certain safety risks (for example, recent scalp wound, significant bleeding in/near the tumor, or dangerously high pressure in the brain)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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