Ultrasound treatment to temporarily open the brain blood barrier
Part of Brain & nervous system, Cancer clinical trials.
This study looks at using focused ultrasound to temporarily loosen the brain’s “blood barrier” around certain brain tumors, while people still get standard surgery. It aims to help doctors learn how safe the approach is and collect blood/fluid samples during the operation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have, or likely have, a diffuse brain glioma on scans (tumor about 3 cm or larger) that surgeons plan to treat with surgery
- You are already planning to have tumor surgery as part of routine care at Mayo Clinic in Rochester, Minnesota
- Your tumor size/location should allow doctors to target about half with ultrasound while leaving some nearby brain tissue untouched for surgery
- You can provide written consent to join the study and for added tissue/blood sample banking (biorepository) during the procedure
- Your overall health function is good enough for the trial (ECOG 0, 1, or 2), and you’re able/willing to undergo surgery
- You may need to use specific imaging/monitoring medicine (Definity®) and must not have contraindications to it
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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