Ultrasound plus immune cells for brain tumors
Part of Brain & nervous system, Cancer clinical trials.
This trial tests a new way to treat a type of brain tumor called diffuse midline glioma. It uses focused ultrasound to open a tiny gap in the blood-brain barrier, which may help special immune cells (T-cells) reach and attack the tumor. The goal is to see if this combination is safe and helpful.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 3 and 25 years old.
- You have a tumor in the pons or thalamus (parts of the brain) that has been treated with standard radiation.
- You have enough blood cell counts and your organs are working well enough to participate.
- You are able to have a small device placed in your brain to deliver the immune cells.
- You have not had other cancer treatments besides radiation and certain allowed medications.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This early-phase trial tests a customized vaccine (made from your tumor’s cell parts) along with an immune “checkpoint blocker” medicine. It’s for newly diagnosed DIPG/DMG to see if this combination is safe and can help control the cancer.
This trial tests whether a special ultrasound (LIFU) can open the blood-brain barrier to help an immunotherapy drug (cetuximab) reach glioblastoma tumors better. It is for people with a specific type of glioblastoma that has not been treated yet and that has a certain protein called EGFR.
This trial tests if combining focused ultrasound (which opens the blood-brain barrier) with the immunotherapy drug nivolumab can treat relapsed or progressive brainstem gliomas and other high-grade brain tumors in children and young adults.
This trial tests a new treatment called sonodynamic therapy that uses sound waves and a special drug to target brain tumors that have come back. It aims to see if this approach is safe and can shrink tumors in people who are eligible for surgery.
This trial tests a new immune therapy using your child's own specially trained white blood cells to fight brain tumors. The treatment is given directly into the fluid around the brain, and it is for children with specific types of brain cancer.
This trial tests whether using focused ultrasound to temporarily open the blood-brain barrier can help chemotherapy (temozolomide) reach a brain tumor called diffuse midline glioma more effectively. The goal is to see if this procedure is safe and feasible in patients who have already completed radiation therapy.
Hear when a new Diffuse Intrinsic Pontine Glioma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.