Maintenance brain stimulation for difficult-to-treat depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether a type of brain stimulation called repetitive transcranial magnetic stimulation (rTMS) can help maintain improvement in people with treatment-resistant depression. It's given as a maintenance treatment to see if it can keep symptoms from coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 60 years old.
- You have been diagnosed with depression that hasn't improved with at least two other treatments.
- You are currently taking a stable dose of the antidepressant venlafaxine (150 mg per day).
- You are right-handed.
- You are not pregnant or breastfeeding.
- You do not have any metal implants in your head/neck, a history of seizures, migraines, or head trauma.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a type of brain stimulation called cTBS (continuous theta burst stimulation) applied to a specific part of the brain (the precuneus) to see if it helps with treatment-resistant depression. It aims to provide a new option for people who haven't found relief from standard treatments.
This study tests a new way of delivering brain stimulation called rTMS to treat depression that hasn't improved with standard treatments. The goal is to see if targeting specific brain areas helps reduce depression symptoms more effectively.
This trial tests a new type of brain stimulation treatment for people with major depression that hasn't improved with standard treatments. The treatment uses magnetic pulses to target specific brain areas over about 2 weeks.
This study is testing whether a new type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with treatment-resistant depression (depression that hasn't improved with standard medicines). It also looks at certain blood markers to see if they can predict how well someone will respond to this treatment.
This study compares two fast types of brain stimulation (called accelerated theta burst stimulation) to see which works better for people whose depression hasn't improved with standard antidepressants. It's designed for people with treatment-resistant depression who are already on a stable antidepressant.
This trial compares different modes of transcranial magnetic stimulation (TMS)—a non-invasive brain stimulation technique—to see which works better for people with treatment-resistant depression. If you've tried multiple antidepressants without relief, this study may offer a new option.
Hear when a new Treatment Resistant Depression (TRD) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.