Clin2
NCT07761936Possibly a fitRecruiting

Safinamide for Parkinson's disease pain

PARKINSON DISEASE (Disorder)PainPain ManagementParkinson Disease (PD)

Part of Brain & nervous system, Pain clinical trials.

This study tests whether safinamide, an add-on medication for Parkinson's disease, can reduce chronic pain in people who also experience motor fluctuations (times when symptoms return between doses). It aims to see if this treatment can improve pain and quality of life.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
60 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be at least 18 years old
  • You have Parkinson's disease with pain lasting more than 3 months
  • You have motor fluctuations (more than 1.5 hours of 'off' time each day) despite stable levodopa treatment
  • Your Parkinson's symptoms respond to levodopa
  • You have had pain in the last 12 weeks scoring at least 4 on a 0-10 pain scale
  • You can speak and understand Italian and are willing to follow the study procedures

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06817200Not yet recruiting· Phase 2
Amantadine for motor fluctuations in advanced Parkinson's disease

This trial tests whether adding amantadine to usual Parkinson's medications can reduce the 'off' periods when symptoms return and movement becomes harder. It is for people with advanced Parkinson's who still have daily off periods despite their current treatment.

Toulouse
NCT05981261Recruiting
Experimental pain study in Parkinson's and healthy adults

This study looks at how people with Parkinson’s, treated either with levodopa or deep brain stimulation (DBS), and healthy volunteers experience pain. The goal is to understand how Parkinson’s treatments affect pain perception.

Aarhus
NCT07422675Recruiting· Phase 1
Study of a new treatment for Parkinson's with motor fluctuations

This study tests a new single-dose treatment for Parkinson's disease to see if it can help reduce 'off' time—when medication wears off and symptoms return. It is for people who experience motor fluctuations and are already on a stable medication routine.

Englewood, Colorado
NCT06008704Recruiting
PET scan study of pain in Parkinson's disease

This study uses a special brain scan (PET) to look at the serotonin system in people with Parkinson's who have chronic pain. The goal is to understand why some people feel pain and how the brain chemical serotonin might be involved.

Toulouse, Haute-Garonne
NCT07702266Not yet recruiting
Parkinson's pain study

This study looks at pain in people with Parkinson's disease to understand how it relates to their condition and what it feels like. It may help improve pain management for Parkinson's patients.

Clermont-Ferrand
NCT07514858Recruiting· Phase 2
Lu AF28996 for Parkinson's Disease Motor Fluctuations

This trial tests a new medication called Lu AF28996 to help reduce the periods when Parkinson's symptoms worsen throughout the day (called 'OFF times'). If you have motor fluctuations that are predictable and affecting your daily life, this study might help you experience fewer of these difficult periods.

Farmington Hills, Michigan

Hear when a new PARKINSON DISEASE (Disorder) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.