SG301 for kidney transplant rejection
Treatments studied
Part of Immune system & allergy, Kidney & urinary clinical trials.
This trial tests a new drug called SG301 for people whose kidney transplant is being rejected by their own antibodies (antibody-mediated rejection, or AMR). The drug targets a protein on antibody-producing cells to help stop the rejection and protect the transplanted kidney.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 75 years old.
- You have had a kidney transplant at least 6 months ago.
- A kidney biopsy shows a type of rejection called antibody-mediated rejection (AMR).
- Your kidney function is stable enough (eGFR at least 20).
- You have not had certain anti-rejection treatments (like IVIG, plasma exchange, or rituximab) within the last 3 months.
- You do not have active infections, certain cancers, or other serious medical conditions that would make the trial unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests an experimental drug called CID-103 to treat antibody-mediated rejection (ABMR), a type of immune response that damages transplanted kidneys. The drug targets immune cells that attack the transplant, and researchers hope it may help preserve kidney function and prevent transplant failure.
This study tests a new combination of drugs (an antibody called CD38 mAb plus azathioprine) to treat a type of chronic rejection that can happen months or years after a kidney transplant. The goal is to see if it can help stabilize or improve kidney function and prevent further damage.
This trial tests whether belatacept can help prevent damage in kidney transplant recipients who develop new antibodies against their donor kidney. It is for people whose kidney function is still stable, which may allow treatment to slow or stop antibody-related injury.
This study tests a new treatment called BiTE (a type of immunotherapy that helps your immune cells attack harmful antibodies) for people whose transplanted kidney is being damaged by chronic active antibody-mediated rejection. The goal is to see if it can safely slow or stop this damage.
This trial tests a blood test that may help monitor kidney transplant health by detecting signs of rejection earlier. It aims to see if using this blood test can lead to better long-term outcomes for transplant recipients.
This trial tests whether giving a special type of umbilical cord cell can help treat a form of kidney rejection that hasn't improved with standard antibody treatment. It aims to slow down or stop further kidney damage.
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