Intravenous magnesium for acute headache pain relief
Treatments studied
Part of Brain & nervous system, Pain clinical trials.
This study compares two doses of intravenous (IV) magnesium to see which is more effective at relieving acute headache pain in the emergency department. It aims to provide a fast and effective treatment option for migraine, tension-type, or cluster headaches.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You are in the emergency department with a headache that has lasted less than 72 hours.
- Your headache is a primary headache disorder such as migraine, tension-type, or cluster headache.
- Your headache pain is moderate to severe (at least 5 out of 10 on a pain scale).
- You have not taken any pain medication in the last 6 hours.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if adding magnesium to a standard migraine medication (prochlorperazine) helps treat migraines more effectively. It could be a good option for adults with migraines who haven't taken these drugs recently.
This trial tests two new migraine medicines, rimegepant and zavegepant, given to people in the emergency department to see how well they work for stopping a migraine headache quickly.
This trial tests whether giving magnesium sulfate through a vein in the emergency room can reduce sudden (non-injury) acute headaches compared with a placebo. It may help people whose headache comes on suddenly and is not caused by an injury.
This trial tests whether an IV magnesium injection can quickly reduce severe period pain. If you have very painful periods without other underlying conditions, this study may help find better relief options.
This trial tests whether giving magnesium sulfate (a mineral given through an IV) soon after a moderate head injury can reduce swelling and inflammation in the brain. It may help improve recovery by calming the brain's immune response.
This trial tests whether a magnesium infusion can better control pain in adults who have serious injuries and need intensive care. It compares magnesium as part of pain treatment to standard pain care to see if pain improves and stays controlled.
Hear when a new Migraine trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.