MRI scans to study gut function in cystic fibrosis
Part of Digestive system, Genetic & congenital, Lungs & breathing clinical trials.
This study uses MRI scans to look at how the gut moves and works in people with cystic fibrosis. It tests a medicine called linaclotide (which helps with constipation) against a placebo to see if it changes gut function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a confirmed diagnosis of cystic fibrosis
- You must be between 18 and 60 years old
- You must be willing to follow the study schedule, including fasting overnight, taking the study drug or placebo, having MRI scans, and eating the provided meals and blue muffins
- You must be able to stop taking certain pain medicines (like ibuprofen or paracetamol) during the study, though some other medicines (like certain antidepressants, allergy medicines, and the pill) are allowed
- You must not have had any intestinal surgery (other than appendix removal) or have any other serious digestive condition
- You must not have taken any IV or oral antibiotics in the last 2 weeks (except preventive ones like azithromycin)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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