Ultra-accelerated TMS with NRX-101 for depression
Part of Mental health clinical trials.
This study tests a new approach for depression: a single day of ultra-accelerated transcranial magnetic stimulation (TMS) combined with one dose of an experimental drug called NRX-101. It aims to see if this combination can quickly improve mood in people with moderate to severe depression.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have moderate to severe depression, as measured by specific scores on two standard rating scales.
- You cannot have a history of manic or hypomanic episodes (bipolar disorder).
- You cannot have a psychotic disorder (like schizophrenia) or current hallucinations/delusions.
- You cannot have an active alcohol or substance use disorder, a history of traumatic brain injury, or certain neurological conditions.
- You cannot be pregnant or breastfeeding, and must agree to a pregnancy test if you are of childbearing potential.
- You cannot have metal in your head or neck, a history of seizures, or other conditions that would make TMS unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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