Deep cleaning with and without blood concentrate for severe gum disease
Treatments studied
Part of Mouth & dental clinical trials.
This study compares three ways to treat advanced gum disease without surgery: deep cleaning alone, deep cleaning with a special blood concentrate called i-PRF (made from your own blood to help healing), and deep cleaning with i-PRF plus an antibacterial rinse. It aims to see which approach works best for reducing gum pockets and improving oral health.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older and able to come to the clinic for a 6-month check-up.
- You must have advanced gum disease (called stage III periodontitis) with deep gum pockets and some bone loss around your teeth.
- You need to have at least 10 teeth in each jaw and at least two teeth with deep pockets in each part of your mouth.
- You cannot smoke more than 10 cigarettes a day.
- You cannot be pregnant or nursing, and you must not have serious health conditions.
- You must not have had gum treatment (deep cleaning or surgery) recently, and you must not have taken antibiotics or anti-inflammatory drugs in the last 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether adding I-PRF (a concentrate from your own blood), povidone-iodine, or laser treatment to standard deep-cleaning helps smokers and non-smokers with gum disease. You may qualify if you have moderate to severe gum disease with at least one bleeding pocket in each area of your mouth.
This trial tests if adding platelet-rich fibrin (a natural healing concentrate from your blood) to standard deep cleaning improves treatment for advanced gum disease. It may help patients with widespread gum disease who have not had treatment in the last year.
This study tests whether adding a special injection made from your own blood (platelet-rich fibrin) to standard deep-cleaning gum treatment helps improve gum health more than the cleaning alone. It may help reduce gum pocket depths and improve healing.
This trial tests whether a special blood-derived gel (called Alb-PRF) can improve the results of standard deep cleaning for gum disease. If you qualify, half your mouth will get the standard treatment and the other half will get the standard treatment plus this gel, to see which works better.
This study tests whether injecting a special substance made from your own blood can help treat deep gum pockets without surgery. It may be an option for people with advanced gum disease who have already had initial cleaning.
This study tests a new injectable treatment using your own blood cells to help repair damaged gum tissue and bone around teeth affected by periodontal disease (gum disease). The goal is to see if this minimally invasive approach can regenerate healthy gum and bone without major surgery.
Hear when a new Bony Defects trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.