Gum disease treatment with I-PRF, iodine, or laser in smokers and non-smokers
Treatments studied
Part of Mouth & dental clinical trials.
This trial tests whether adding I-PRF (a concentrate from your own blood), povidone-iodine, or laser treatment to standard deep-cleaning helps smokers and non-smokers with gum disease. You may qualify if you have moderate to severe gum disease with at least one bleeding pocket in each area of your mouth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have gum disease (Periodontitis) at stage II, III, or IV.
- You have at least one gum pocket deeper than 4 mm that bleeds, in each section of your mouth.
- You are not pregnant or breastfeeding.
- You have not had radiation or chemotherapy to your head or neck.
- You are not allergic to iodine or methylene blue.
- You have not used antibiotics in the last 30 days, do not take daily steroids or immunosuppressants, and do not have type 1 or 2 diabetes.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study compares three ways to treat advanced gum disease without surgery: deep cleaning alone, deep cleaning with a special blood concentrate called i-PRF (made from your own blood to help healing), and deep cleaning with i-PRF plus an antibacterial rinse. It aims to see which approach works best for reducing gum pockets and improving oral health.
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This trial tests whether a special blood-derived gel (called Alb-PRF) can improve the results of standard deep cleaning for gum disease. If you qualify, half your mouth will get the standard treatment and the other half will get the standard treatment plus this gel, to see which works better.
This trial tests adding a special laser (diode laser) to standard deep cleaning for gum disease. The goal is to see if the laser helps reduce infection and improve healing better than cleaning alone.
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