Comparing two drugs for liver graft-versus-host disease
This trial compares two medications, belumosudil and ruxolitinib, to see which one works better for a type of graft-versus-host disease (GVHD) that affects the liver after a stem cell transplant. GVHD happens when donor cells attack the patient's body, and this study focuses on patients whose liver GVHD has not improved with steroids or has gotten worse. The study aims to find a more effective treatment to control this condition.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 12 years or older.
- Had a stem cell transplant from a donor (allogeneic).
- Have liver problems caused by graft-versus-host disease (GVHD), such as high bilirubin or liver enzymes.
- Be able to take pills by mouth.
- Have a life expectancy of at least 6 months.
- Have adequate organ function, including blood counts and kidney function (creatinine clearance of at least 30 mL/min).
- Be either in Group 1 (liver GVHD did not improve after at least 4 weeks of steroids) or Group 2 (liver GVHD developed or worsened while taking ruxolitinib or belumosudil for other GVHD, and you have not taken the other study drug before).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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