Breathing mode study for severe lung failure
Part of Lungs & breathing clinical trials.
This study tests a different way of breathing (called APRV mode) on a ventilator for people with severe lung failure (ARDS). It aims to see if this mode helps improve lung function and breathing mechanics.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 80 years old.
- You have moderate-to-severe ARDS (a serious lung condition) and are on a breathing machine, diagnosed within the last 48 hours.
- After one hour of standard ventilator settings, your blood oxygen level must be very low (PaO2/FiO2 of 150 or less).
- You cannot have severe chronic lung or heart conditions, recent major chest surgery, or a hole in the lung.
- You cannot have a pacemaker or defibrillator, or extensive chest skin problems.
- You cannot have certain other conditions like severe brain injury, blood clotting problems, or be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at starting a specific type of breathing machine setting early in people with ARDS (a serious lung problem) to see if it improves outcomes. You might be able to take part if you are within 48 hours of needing a breathing tube and meet the lung oxygen criteria.
This trial tests a more tailored way to set the amount of air delivered by a ventilator in people with severe ARDS. The goal is to see if personalized breathing settings can improve breathing and heart-related monitoring while patients are in intensive care.
This study looks at a specific breathing event (“avalanche phenomenon”) when the lungs are opened in people with early, moderate-to-severe ARDS. The goal is to understand what’s happening in the lungs and whether it can guide better care.
This study tests two methods of adjusting a ventilator to see which one may better protect the lungs of patients with ARDS. It will help doctors learn how to set the machine to reduce strain on the lungs.
This study tests a smarter way to set the breathing machine's pressure in people with serious lung failure (ARDS) who are also being turned onto their stomachs to help their lungs. It aims to see if using a special chest monitor (EIT) can improve oxygen levels and lung function.
This trial compares two ways to set the breathing machine for people with ARDS (a serious lung injury). One method uses a special imaging belt (EIT) to see how the lungs are working, while the other uses pressure measurements. The goal is to find the best way to adjust ventilator support to help you breathe more easily.
Hear when a new Acute Respiratory Distress Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.