Lower-dose clot-busting drug for severe pulmonary embolism
Part of Heart & circulation, Lungs & breathing clinical trials.
This trial compares a lower dose of the clot-dissolving medicine alteplase to the standard full dose for people with a severe pulmonary embolism (a blood clot in the lungs). The goal is to see if the lower dose is just as safe and effective, with fewer bleeding risks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a confirmed or highly suspected blood clot in your lungs (pulmonary embolism).
- Your condition is severe, meaning you have signs of shock, low blood pressure, or heart strain, or you need extra oxygen due to the clot.
- If you are a woman who could become pregnant, you must have a negative pregnancy test.
- You have not had a major bleeding event, recent stroke, or major surgery in the past few weeks, and you are not on full-dose blood thinners.
- You have not already received clot-busting treatment for this blood clot.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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