Vortosiran to prevent repeat blood clots
Part of Cancer, Heart & circulation, Lungs & breathing clinical trials.
This trial tests whether a new medicine called vortosiran can help prevent future blood clots. It's for people who've already had a blood clot or who have cancer and are starting chemotherapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have had a confirmed blood clot in your leg (deep vein thrombosis) or lung (pulmonary embolism) within the last 3 to 12 months, and you've finished at least 3 months of standard blood thinner treatment.
- Or, you have active cancer (solid tumor or lymphoma) and are about to start a new chemotherapy course. You haven't had chemo or radiation in the past 3 months and no surgery in the past 2 weeks.
- You are not pregnant, breastfeeding, or planning to become pregnant during the trial. If you can become pregnant, you must agree to use highly effective birth control.
- You do not have active hepatitis B, hepatitis C, or HIV infection.
- Your kidney function is adequate (estimated GFR of 30 or higher).
- You are not at high risk for bleeding (e.g., no recent major bleeding, no untreated stomach ulcers, no recent blood transfusion for bleeding). For those with cancer (Cohort B), you don't have certain high-bleeding-risk conditions like untreated brain tumors or liver disease with bleeding problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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