Tranexamic acid in bone to reduce bleeding during knee replacement
Treatments studied
Part of Bones, joints & muscles clinical trials.
This study tests whether putting tranexamic acid (a medicine that helps blood clot) directly into the bone during knee replacement surgery can reduce blood loss. It may help people recover with less need for blood transfusions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 50 and 85 years old.
- You have knee osteoarthritis (wear-and-tear arthritis) and are scheduled for a first knee replacement on one knee.
- You are generally healthy or have mild to moderate health conditions (classified as ASA I–III).
- You are not allergic to tranexamic acid, have no history of blood clots, and do not take blood-thinning medication (except as part of surgery).
- You do not have severe heart, liver, or kidney disease, and you have not had previous surgery on the same knee.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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