Brain scan study for heart failure patients starting a new medicine
Treatments studied
Part of Brain & nervous system, Heart & circulation, Mental health clinical trials.
This study uses a special brain scan to look for inflammation in people with heart failure who are starting a new medication called sacubitril-valsartan. It may help doctors understand how heart failure affects the brain and guide future treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 50 and 75 years old.
- You have heart failure with a reduced pumping ability (ejection fraction of 40% or less).
- You have mild memory or thinking problems (a score of 18–25 on a standard test).
- Your doctor has decided to start you on sacubitril-valsartan for your heart failure.
- You are able to lie flat for about 90 minutes for a scan, and you do not have any metal implants that prevent an MRI.
- You must be able to understand and speak English for the consent and tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1 study tests a PET scan to measure inflammation-related changes in the brain using a medication called ketoprofen. It may help researchers understand which people with certain brain diseases could benefit from treatments aimed at inflammation.
This study uses a special PET scan to look for inflammation in the brains of people with Alzheimer's or related dementias. It may help researchers understand how inflammation affects memory and thinking problems.
This study uses a special PET scan to look for scarring (fibrosis) in the heart muscle of people with heart failure. It may help doctors better understand why some hearts get stiff or weak.
This trial is testing a new imaging method (68Ga-FAPI PET/CMR) to better see and understand heart problems. It might help doctors diagnose or monitor conditions like heart failure or inflammation.
This trial uses a special MRI technique with carbon dioxide to check how well blood flows to your heart muscle. It might help doctors better understand blockages in the heart arteries.
This study uses a special PET scan (68Ga-FAPI) to look at inflammation in the heart. It may help researchers understand heart failure and cardiac sarcoidosis better.
Hear when a new Heart Failure With Reduced Ejection Fraction trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.