Focal electric seizure therapy for depression
This trial tests a new type of electric brain stimulation, called FEAST, as a treatment for severe depression. It aims to see if it can help improve mood with potentially fewer side effects than standard electroconvulsive therapy (ECT).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 90 years old.
- You have moderate to severe depression (with or without bipolar disorder).
- You have tried or been recommended ECT (electroconvulsive therapy) for depression.
- You can understand the study procedures and attend study visits.
- You are willing to adjust some medications (like lithium or anticonvulsants) and limit benzodiazepine use during the trial.
- You do not have a history of neurological conditions (like epilepsy, stroke, or brain tumors) or metal implants near your head.
- You are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study measures changes in your blood and/or body chemistry while you receive electroconvulsive therapy (ECT) for a severe mood episode. The goal is to understand biological signals related to ECT and treatment-resistant depression, which may help improve future care.
This trial tests a non-invasive treatment that uses small electrical pulses to help activate facial muscles involved in smiling, which may improve mood in people with depression. It involves 20 sessions over about two weeks, plus a four-week follow-up.
This trial tests a new type of seizure therapy (low amplitude pulse seizure therapy) against the standard ultra-brief right unilateral ECT for people with severe depression, including those with suicidal thoughts. The goal is to see which treatment works better.
This study compares two types of brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—to see which works better for people with certain mental health conditions. It may be an option if you have a mood disorder or vision problems that could be helped by these treatments.
This study compares two brain stimulation treatments—Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT)—to see which works better for severe depression. If you are on a stable antidepressant and haven't had recent brain stimulation, this trial may be an option for you.
This trial studies better ways to deliver ECT (electroconvulsive therapy) for people with difficult-to-treat depression, including some people with bipolar depression. You may be offered an ECT strategy that’s tailored to your situation, with the goal of improving outcomes and reducing problems.
Hear when a new Major Depressive Episode (MDE) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.