Clin2
NCT07866430Possibly a fitNot yet recruiting

Lower dose of letrozole for early breast cancer

Brest Cancer ER+ and HER2 Negative

Treatments studied

This trial tests if a lower dose of the hormone therapy drug letrozole can work as well as the standard dose for people with early-stage hormone receptor-positive breast cancer. The lower dose may cause fewer side effects while still helping to prevent the cancer from coming back.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
144 people
Ages
18 years to 59 years
Study type
Interventional

Who can take part

  • You have been diagnosed with early-stage breast cancer (stage I to III) that has not spread far.
  • Your tumor tests positive for estrogen receptors (ER positive) and negative for HER2.
  • You are postmenopausal and were female at birth.
  • You are 18 years or older and are planning to have surgery for your breast cancer before starting any other treatment.
  • You have not received any prior treatment for this breast cancer.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04563507Recruiting· Phase 2
Immunotherapy plus hormone therapy for metastatic ER-positive breast cancer

This Phase 2 study tests a combination of immune-based treatments along with hormone (endocrine) therapy to slow or shrink advanced, hormone-receptor positive, HER2-negative breast cancer. You may be a candidate if your cancer has progressed after standard hormone-blocking medicines and you can start treatment with CDK4/6 medicine plus an aromatase inhibitor.

New York, New York
NCT06507618Recruiting· Phase 3
Pre-surgery hormone therapy to guide radiation decisions for breast cancer

This trial tests whether taking hormone therapy for 3 months before breast-conserving surgery can help doctors decide if radiation is right for you. It is for women aged 65 and older with a common type of breast cancer that is hormone receptor-positive and HER2-negative.

New Haven, Connecticut
NCT07153757Not yet recruiting· Phase 3
Less intense therapy for early-stage breast cancer

This trial is testing a lower dose of treatment for women with small, early-stage breast cancer that is hormone-positive and has not spread to lymph nodes. The goal is to find out if it can be as effective as the standard treatment with fewer side effects.

Shanghai
NCT07394946Not yet recruiting· Phase 2
Letrozole before surgery for early-stage breast cancer

This trial tests whether taking letrozole, a hormone-blocking pill, before surgery can help shrink estrogen-positive breast cancer. It is for women who have gone through menopause and have early-stage cancer that has spread to nearby lymph nodes.

Lahore, Punjab Province
NCT05601700Recruiting· Phase 3
Letrozole for low-grade ovarian cancer that uses hormones

This study tests whether letrozole, a hormone-blocking medicine, can help people with newly diagnosed low-grade serous ovarian cancer that has hormone receptor proteins (ER and/or PgR) after surgery. It compares outcomes to see if blocking estrogen can slow the cancer’s return or progression.

Arezzo, AR
NCT04852887Recruiting· Phase 3
Testing shorter breast radiation after low-risk hormone breast cancer

This Phase 3 trial studies whether “less intense” radiation can work as well as standard radiation for certain early-stage hormone receptor–positive, HER2-negative breast cancers that have a low Oncotype DX score. It may help reduce treatment burden while keeping cancer control strong.

Birmingham, Alabama

Hear when a new Brest Cancer ER+ and HER2 Negative trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.