Clin2
NCT07878871Possibly a fitNot yet recruiting

Firmonertinib plus chemo for advanced EGFR-mutant lung cancer

Lung AdenocarcinomaStage III Lung CancerEGFR Positive Non-small Cell Lung Cancer

Treatments studied

Part of Cancer, Lungs & breathing clinical trials.

This trial tests a new targeted pill (Firmonertinib) combined with standard chemotherapy for stage III lung cancer that cannot be removed by surgery. It is for people with a specific EGFR mutation, and the goal is to see if the combo helps shrink or control the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
27 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have stage III lung cancer that cannot be removed with surgery (confirmed by biopsy).
  • Your tumor has a specific EGFR PACC mutation (a genetic change) found by a lab test.
  • You have not had any previous treatment for this cancer, like chemo, radiation, or other therapies.
  • You have at least one tumor that can be measured on a scan and has not been treated with radiation.
  • You are 18 years or older and your overall health is reasonably good (able to do light activities).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07622706Not yet recruiting· Phase 2
Firmonertinib before and after surgery for EGFR-mutated lung cancer

This trial tests a targeted therapy pill (firmonertinib) given before and after surgery for stage II–III lung adenocarcinoma that has an EGFR mutation. The goal is to see if this approach can shrink the tumor before surgery and reduce the chance of cancer coming back.

NCT07298148Not yet recruiting· Phase 2
Higher-dose firmonertinib after stable disease on initial treatment

This trial tests whether a higher dose of the targeted pill firmonertinib (160 mg) can better control advanced lung cancer in people who have a specific EGFR mutation and whose disease remained stable after a lower dose for 8 weeks. The goal is to see if the higher dose improves outcomes.

NCT07314216Recruiting· Phase 2
Firmonertinib plus radiation for stage III lung cancer with rare EGFR mutations

This trial tests whether combining the targeted pill firmonertinib with radiation therapy can help people with stage III non-small cell lung cancer that has certain rare EGFR mutations. It is for those whose cancer cannot be removed by surgery.

Changsha, Hunan
NCT06890182Not yet recruiting· Phase 2
Targeted therapy plus chemotherapy before surgery for EGFR-mutated lung cancer

This trial tests a targeted therapy (firmonertinib) combined with standard chemotherapy before surgery, to see if it can shrink tumors and improve outcomes for people with early-stage lung cancer that has a specific EGFR gene change.

NCT07661173Not yet recruiting· Phase 2
Targeted therapy guided by blood tests for EGFR-mutated lung cancer

This study tests an oral targeted therapy (firmonertinib) as the first treatment for advanced EGFR-mutated non-small cell lung cancer. It uses blood tests (ctDNA) to see if the drug is working and to guide whether to continue or adjust treatment, aiming to improve outcomes while reducing side effects.

Hefei, Anhui
NCT06956001Recruiting· Phase 3
Testing firmanertinib vs chemo for first-line lung cancer with specific EGFR mutations

This trial compares a new targeted therapy pill (firmanertinib) to standard chemotherapy in people with advanced non-small cell lung cancer whose tumors have a specific EGFR mutation (PACC or L861Q). If you haven't had treatment for advanced disease and your cancer matches these mutations, this study may offer a more convenient oral option.

Beijing, Beijing Municipality

Hear when a new EGFR Positive Non-small Cell Lung Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.