Brain changes and heart rhythm in hard-to-treat epilepsy
Part of Brain & nervous system clinical trials.
This study looks at whether changes in a part of the brain (the hypothalamus) are linked to heart rate problems in people with epilepsy that doesn't improve with medication. The results might help doctors better understand and care for people with difficult-to-control seizures.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have epilepsy that has not been controlled by at least two medications.
- You are being treated at Amiens Picardie University Hospital in France.
- You have had a seizure recorded on a brain wave test (video-EEG or SEEG) in the past 4 years.
- You have had a good-quality EEG with heart monitoring (ECG) in the last 6 months.
- You are able to have an MRI (no metal implants, no severe claustrophobia) and lie still for 40 minutes.
- You do not have a history of heart problems, high blood pressure, or certain endocrine or eating disorders.
- You do not have seizures that are psychological in origin (dissociative functional seizures).
- You do not have epilepsy caused by a specific genetic change (like SCN1A) or a hypothalamic hamartoma.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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