Clinical trials · California
Acute Pain clinical trials in California
We’re tracking 13 recruiting acute pain studies with a site in California — including Phase 1, Phase 2, Phase 2/Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT05266040RecruitingPhase 2
Valacyclovir to reduce pain from infected tooth abscess
This Phase 2 study tests whether valacyclovir, an antiviral medicine, can help reduce moderate-to-severe pain from an acute infected tooth abscess. Participants also receive standard dental treatment, and the study looks at whether the added medicine helps with pain.
San Francisco, CaliforniaAges 18–80 - NCT07119645Recruiting
Collagen supplement for knee discomfort relief
This trial tests whether a daily collagen supplement (NT-II™) can reduce knee discomfort during activities like walking or climbing stairs. You may qualify if you have mild to moderate knee pain during exercise, no arthritis, and are generally healthy.
San Francisco, CaliforniaAges 20–65 - NCT07335913RecruitingPhase 1
Testing SBS-147 in healthy adults for safety
This study tests a new drug, SBS-147, in healthy adults to see if it's safe and how the body processes it. It may help find the right dose for future studies in people with certain conditions.
Cypress, CaliforniaAges 18–55 - NCT06020677Recruiting
Latinx children and surgery study
This study looks at how Latinx families manage their child's pain after outpatient surgery. It aims to improve care for Spanish-speaking families.
Orange, CaliforniaAges 2–7 - NCT04166877RecruitingPhase 4
Magnesium drip to reduce pain in ICU trauma patients
This trial tests whether a magnesium infusion can better control pain in adults who have serious injuries and need intensive care. It compares magnesium as part of pain treatment to standard pain care to see if pain improves and stays controlled.
Sacramento, CaliforniaAges 18 years+ - NCT06960317Recruiting
Numbing injection for IUD placement pain
This study tests whether a numbing injection (lidocaine) in the cervix can reduce pain during IUD placement. It's for women who have never had a vaginal birth and are getting their first IUD.
La Jolla, CaliforniaAges 18–50 - NCT04849455RecruitingPhase 4
Nerve-block catheters plus spinal morphine for liver surgery pain
This trial tests whether placing pain-relief catheters near the back muscle plus giving morphine into the spinal fluid can improve comfort during and after liver surgery. It may help reduce the need for stronger opioid pain medicines afterward.
San Diego, CaliforniaAges 18 years+ - NCT07463430Enrolling by invitationPhase 4
Suzetrigine for pain after non-mastectomy breast surgery
This trial tests a new pain medication, suzetrigine, for people having breast surgery (not mastectomy) who are expected to have moderate pain. It checks if this drug works well compared to standard options.
San Diego, CaliforniaAges 18 years+ - NCT07145346Enrolling by invitationPhase 4
Suzetrigine for pain relief after multiple rib fractures
This trial tests a new medicine, suzetrigine, for managing acute pain in adults who have broken three or more ribs from a blunt injury. It aims to see if this painkiller works well and is safe for you.
Orange, CaliforniaAges 18 years+ - NCT05091905Enrolling by invitationPhase 4
Tested nerve-block pain pumps after arm or leg surgery
This trial studies whether a timed, stop-and-go pain medicine delivery works better than a steady drip after surgery. It’s done using a small catheter placed near a nerve to help control pain.
San Diego, CaliforniaAges 18 years+ - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT06859723RecruitingPhase 1
Effects of high potency cannabis on daily users
This study tests how high potency cannabis affects mood, thinking, and pain sensitivity in people who smoke cannabis almost every day. It will help researchers understand both immediate and long-lasting effects.
Los Angeles, CaliforniaAges 21–55 - NCT05658575RecruitingPhase 2/Phase 3
Tablets to treat sudden gout flare pain
This trial studies dapansutrile tablets (OLT1177) to see how well they work for people in the first 4 days of an acute gout flare. It may help reduce pain and inflammation in the specific joint where your gout is flaring.
San Diego, CaliforniaAges 18 years+
Where these studies are running in California
Institutions with a site for the recruiting acute pain studies listed above.
- University of California San Diego · 2 studies
- University of California San Diego Health · 2 studies
- Alethios, Inc.
- Altasciences Clinical Los Angeles, Inc.
- American Institute of Research
- Children's Hospital of Orange County
- TriWest Research Associates
- UC San Diego Medical Center
What taking part in a acute pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Acute Pain trials in other states
Common questions
- Are there acute pain clinical trials in California?
- Yes. We're currently tracking 13 recruiting acute pain studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a acute pain study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a acute pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New acute pain studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.