Clinical trials
Addiction clinical trials
Below are recruiting addiction clinical trials, each written for real people, not researchers. We’re tracking 201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05563363Recruiting
Home-based treatment for severe addiction problems
This trial tests a home-based treatment approach for adults with severe substance use problems. It may help you and your care team manage addiction with structured support while you stay at home.
GenevaAges 18 years+ - NCT06548490RecruitingPhase 2
Semaglutide for Opioid Use Disorder
This study tests whether a once-weekly injection of semaglutide (a GLP-1 receptor agonist) can reduce opioid use in people who are already on buprenorphine or methadone but still using opioids. It lasts about 19 weeks.
Baltimore, MarylandAges 18–75 - NCT06534047RecruitingPhase 4
Brain stimulation or nicotine patch to help you quit smoking
This study tests whether a brain stimulation treatment called rTMS can help people with psychiatric conditions quit smoking. You will be randomly assigned to get either rTMS or a nicotine patch, and your progress will be tracked to see which treatment works better.
Toronto, OntarioAges 18–70 - NCT06518720RecruitingPhase 2
Psilocybin for Chronic Nerve Pain and Depression
This trial tests whether psilocybin (a psychedelic medication) can help people who have both chronic nerve pain and depression that hasn't responded to standard treatments. The goal is to see if it can reduce pain and improve mood.
Toronto, OntarioAges 18–65 - NCT06497920Recruiting
Brain stimulation for motor skills in autistic adults
This trial tests whether a type of brain stimulation called rTMS can improve motor skills (like coordination and movement) in autistic adults. If you have autism and notice challenges with motor function, this study may help.
Toronto, OntarioAges 18–40 - NCT06512220RecruitingPhase 2
Psilocybin for treatment-resistant depression brain imaging study
This study tests whether a psilocybin-based treatment can help people with depression that has not improved after trying several antidepressants. You will receive the study treatment and have brain scans to see how it affects brain connections.
Toronto, OntarioAges 18–65 - NCT06483412Enrolling by invitation
Healthy Futures: A Vaping Intervention for Teens
This study is testing a program called Healthy Futures that schools can use instead of suspending students caught vaping. The trial wants to see if the program helps teens quit vaping.
Palo Alto, CaliforniaAges 14–18 - NCT06472973Recruiting
Addiction support after liver transplant
This trial tests a special addiction support program for people who have had a liver transplant because of alcohol-related liver disease. The goal is to help them stay healthy and avoid drinking again.
BesançonAges 18 years+ - NCT04209153Recruiting
Brain stimulation study to help people quit nicotine addiction
This trial tests whether direct brain electrical stimulation can help people who use tobacco every day. You must have strong nicotine dependence and be able to follow the study in French, while avoiding certain health and safety conditions.
Paris, IDFAges 18 years+ - NCT06408233Recruiting
Improving addiction care in New York
This study looks at how to improve care for people with opioid use disorder in New York State. Researchers want to learn from both patients and their treatment providers to make addiction treatment more person-centered.
New York, New YorkAges 18–64 - NCT06413979Recruiting
Family support program for teens with substance use and mood or anxiety issues
This trial offers a family support program for teens with both substance use and internalizing problems like depression or anxiety. The goal is to help you and your caregiver work together to manage symptoms and improve well-being.
Jacksonville, FloridaAges 13–21 - NCT05738174Recruiting
High-dose brain stimulation to help treat alcohol addiction
This trial studies a type of noninvasive brain stimulation to reduce alcohol dependence and help people drink less or stop. You may be offered an accelerated treatment schedule, with regular check-ins and questionnaires to track progress.
RegensburgAges 18–65 - NCT06373484Recruiting
Matching treatment for kids with disruptive behavior and their parents
This study aims to find the best treatment approach for children with disruptive behavior by matching them to either group or individual therapy. It could help if your child struggles with behavior like defiance or conduct issues, and you're willing to participate in treatment.
Toronto, OntarioAges 6–12 - NCT06370988Recruiting
Theta-burst stimulation for bipolar depression
This study tests a type of brain stimulation (theta-burst TMS) to see if it helps improve depression in people with bipolar disorder. It might be a good option if you have tried medication but still feel depressed.
Toronto, OntarioAges 18–65 - NCT06370481Recruiting
HIV and addiction training program for Alabama clinics
This study tests a program to help people living with HIV in Alabama who also struggle with opioid or stimulant use. It takes place at your HIV clinic and checks whether a new approach to addiction care can improve your health.
Birmingham, AlabamaAges 18 years+ - NCT06346028RecruitingPhase 4
TMS for quitting smoking
This study tests whether a brain stimulation therapy called transcranial magnetic stimulation (TMS) can help people quit smoking. It is for adults who smoke daily and are willing to try TMS as a treatment.
Toronto, OntarioAges 18–70 - NCT06232226Recruiting
ADHD and addiction: a study on methylphenidate
This study looks at whether the medication methylphenidate (often used for ADHD) can help people who have both ADHD and an addiction. It aims to see if the medicine is safe and works well for people with both conditions.
Nantes, Loire-AtlantiqueAges 18–99 - NCT03364803Recruiting
Sharing treatment results for people with Cushing’s syndrome
This is a study that collects and reviews information about how people with Cushing’s syndrome (including some mild forms and certain “silent” tumors) are diagnosed and treated, and what outcomes they have. It may help researchers understand which treatments work best in different types of the condition.
Basking Ridge, New JerseyAges 14 years+ - NCT06103370Recruiting
HIV prevention via telemedicine and peer networks
This study tests how well a program combining telemedicine (virtual doctor visits) and peer support can help prevent HIV among people who inject drugs. You'd get trained, attend weekly group sessions, and invite a friend or partner to also take part.
Baltimore, MarylandAges 18 years+ - NCT06086366Recruiting
Brain scan study for depression after COVID-19
This study uses brain scans to understand depression that starts soon after COVID-19. Researchers want to see if there are changes in brain chemistry related to depression, and you may help find new treatment targets.
Toronto, OntarioAges 18–75 - NCT06077240Recruiting
E-cigarettes vs pouches for quitting smoking
This study compares the effects of e-cigarettes and nicotine pouches on smoking habits and addiction. The goal is to see which method helps people smoke less and reduces their dependence on cigarettes.
New Haven, ConnecticutAges 21 years+ - NCT04373629Recruiting
Testing how flexible appearance worries may change in BDD
This study looks at whether training can change how people with body appearance worries (including body dysmorphic disorder) perceive faces or the head. It may help researchers understand new ways to reduce distress related to these concerns.
Toronto, OntarioAges 18–40 - NCT06044285Recruiting
Study of ultra-processed food and food addiction
This study looks at how ultra-processed foods affect the brain and eating behavior in people who may have food addiction. You'll be asked to follow a specific diet and complete surveys, plus possibly a brain scan to see how your brain responds to food.
Ann Arbor, MichiganAges 22–60 - NCT06021548Recruiting
Opioid addiction markers study
This study looks at physical, psychological, and social factors that may be linked to opioid addiction. It aims to better understand addiction to help improve future treatments.
BronAges 18 years+
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Common questions
- Are there clinical trials for addiction?
- Yes. Clin2 currently lists 201 recruiting addiction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a addiction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a addiction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.