Clinical trials
Advanced or Metastatic Breast Cancer clinical trials
Below are recruiting advanced or metastatic breast cancer clinical trials, each written for real people, not researchers. We’re tracking 6,090 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05462236RecruitingPhase 2
Study drug AUM001 with immunotherapy or chemotherapy for metastatic colon cancer
This Phase 2 trial tests AUM001 (a targeted drug) combined with either pembrolizumab (an immunotherapy) or irinotecan (a chemotherapy) in people with metastatic colorectal cancer. It aims to shrink tumors and improve outcomes when standard treatments have already been tried.
Camperdown, New South WalesAges 18 years+ - NCT06494514Recruiting
New chemo combo with immunotherapy and radiation for advanced pancreatic cancer
This trial compares two different chemotherapy combinations, each paired with immunotherapy and radiation, as the first treatment for locally advanced pancreatic cancer. It aims to see which combination works better.
Nanjing, JiangsuAges 18 years+ - NCT07807241RecruitingPhase 1
Study of MX006 for advanced tumors with B7-H3
This trial tests a new drug (MX006) in people with advanced or metastatic tumors that have a specific marker called B7-H3. The drug may work by targeting this marker to stop cancer growth. The study aims to see if MX006 is safe and effective in this patient group.
Sarasota, FloridaAges 18 years+ - NCT07793500RecruitingEarly Phase 1
Nebulized drug for lung metastases from solid tumors
This study tests a new drug given as a mist you breathe in, for people whose cancer has spread to the lungs. The goal is to see if it can shrink tumors or slow their growth.
BeijingAges 18–75 - NCT07797218RecruitingPhase 3
Comparing two drug combinations before breast cancer surgery
This study is comparing two different drug combinations given before breast cancer surgery. The goal is to see which one shrinks tumors more effectively. This type of treatment is called 'neoadjuvant' therapy.
ShanghaiAges 18–70 - NCT06428422Recruiting
Probiotic supplement for advanced lung cancer
This trial tests if taking a probiotic supplement along with your standard lung cancer treatment can help you live longer and respond better to therapy. It is for people with advanced non-small cell lung cancer who have not tried immunotherapy before.
KonyaAges 19–90 - NCT05766800RecruitingPhase 2
PD-1 plus chemotherapy before surgery for advanced lung cancer
This trial studies whether giving a PD-1 antibody together with standard chemotherapy before surgery can improve outcomes for people with stage IIIB–IIIC non-small cell lung cancer. It aims to shrink or control the cancer and make treatment before surgery more effective.
ShanghaiAges 18 years+ - NCT06493760RecruitingPhase 2
Testing a new drug for advanced colorectal cancer
This trial tests a new drug called SSGJ-707 for people with colorectal cancer that has spread. It aims to see if the drug can help shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07746141RecruitingPhase 1
Study of BG-85738 for advanced solid tumors with RAS mutations
This trial is testing a new drug called BG-85738, which may target cancer cells that have a specific change (mutation) in the RAS gene. The goal is to see if it is safe and works against advanced or spreading solid tumors.
South Brisbane, QueenslandAges 18 years+ - NCT04344496Recruiting
Collecting breast cancer tissue to predict recurrence risk
This study builds a “genome atlas” to better predict the chance that breast cancer will come back. It asks participants to share medical information and provide blood and tumor tissue samples, including samples kept in paraffin.
TaipeiAges 20 years+ - NCT07743918Recruiting
Vitamin D and outcomes in locally advanced cervical cancer
This study looks at how vitamin D levels affect treatment results in women with locally advanced cervical cancer who are about to start chemoradiation (chemotherapy plus radiation). It aims to see if higher vitamin D is linked to better outcomes.
Kragujevac, ŠumadijaAges 18–80 - NCT05241405Recruiting
American ginseng to reduce fatigue after cancer treatment
This study tests whether taking American ginseng for 8 weeks can lessen long-lasting tiredness (fatigue) in people who recently finished certain breast or gynecologic cancer treatments. It may help reduce fatigue when other causes have been ruled out.
AmiensAges 18 years+ - NCT07737509Recruiting
Understanding genetic factors in advanced solid tumor treatment
This study collects and analyzes tumor samples from people with advanced solid cancers to understand why some treatments work better than others and why resistance can develop. It aims to improve future treatments for patients like you.
SuttonAges 18 years+ - NCT06639178Recruiting
Cream to prevent hand-foot syndrome from capecitabine in breast cancer
This trial tests whether a special cream containing N-acetylcysteine and urea can prevent the painful hand-foot syndrome often caused by the chemotherapy drug capecitabine. If you have breast cancer and are about to start capecitabine, this study may help reduce side effects.
Aviano, PordenoneAges 18 years+ - NCT05156060RecruitingPhase 1/Phase 2
Gabapentin and ketamine to treat head and neck cancer pain
This early-phase study tests whether gabapentin and a ketamine nasal spray can help prevent or lessen short-term and long-term pain from locally advanced head and neck cancer. It may help by changing how the nervous system responds to pain during and after radiation and chemoradiation.
Nashville, TennesseeAges 21 years+ - NCT06653452Recruiting
PET/MRI for rectal cancer treatment response
This study uses a special scan called PET/MRI to see how well treatment works for locally advanced rectal cancer before surgery. It may help doctors choose the best treatment plan for you.
Beijing, Beijing MunicipalityAges 18–75 - NCT04289935Recruiting
Vacuum biopsy before surgery to check treatment response
This trial studies a special vacuum-assisted biopsy taken just before breast surgery to see how well pre-surgery (neoadjuvant) chemotherapy worked. It may help doctors understand whether patients truly had a complete or near-complete response on scans, which can guide next steps.
SalzburgAges 18 years+ - NCT03788213Recruiting
Shorter vs longer radiation after breast cancer surgery
This trial compares giving breast radiation over one week versus three weeks after surgery. It aims to see whether the shorter schedule works just as well and is safe for people with certain types of early breast cancer.
Kolkata, West BengalAges 18 years+ - NCT07683949Enrolling by invitationPhase 1/Phase 2
Capecitabine plus lenvatinib for advanced colorectal cancer
This trial tests a combination of two oral drugs, capecitabine and lenvatinib, in people with advanced colorectal cancer that has stopped responding to three common chemotherapy drugs. It aims to see if this new combination can help shrink tumors or slow cancer growth.
Seongnam-si, Out of USAges 19–99 - NCT07678957RecruitingPhase 2
Comparing BL-M07D1 vs DS-8201 for HR-positive, HER2-low breast cancer
This trial compares a new drug, BL-M07D1, to an existing treatment (DS-8201) for women with HR-positive, HER2-low breast cancer that has come back or spread. The goal is to see if the new drug works better or has fewer side effects.
Beijing, Beijing MunicipalityAges 18–75 - NCT07679360RecruitingPhase 3
New drug combo for residual triple-negative breast cancer after surgery
This trial tests a new combination of two drugs (trastuzumab rezetecan and adebrelimab) against standard treatments for women with triple-negative breast cancer that wasn't completely removed by chemotherapy. The goal is to see if this combination works better at preventing the cancer from coming back.
Beijing, Beijing MunicipalityAges 18–75 - NCT07676162RecruitingPhase 3
New targeted drug combo for advanced colorectal cancer
This trial tests a new targeted drug (SHR-A1811) combined with chemotherapy and bevacizumab versus the usual therapy for advanced colorectal cancer that hasn't been treated yet. It aims to see if the new combo works better as a first treatment.
Beijing, Beijing MunicipalityAges 18–75 - NCT07672392Recruiting
Exercise after breast reconstruction surgery
This trial tests whether a structured exercise program after DIEP flap breast reconstruction helps improve physical fitness compared to standard care. It may help women recover strength and well-being after surgery.
Beaumont, DublinAges 18 years+ - NCT05911958RecruitingPhase 2
Study drug before surgery for HER2-low, HR-positive breast cancer
This trial tests SHR-A1811 given before surgery (neoadjuvant treatment) for breast cancer that is hormone-receptor positive (HR-positive) and HER2-low. It aims to shrink or control the cancer early and see how well this approach works compared with standard care.
Zhengzhou, HenanAges 18–70
Hear when a new Advanced or Metastatic Breast Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for advanced or metastatic breast cancer?
- Yes. Clin2 currently lists 6,090 recruiting advanced or metastatic breast cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic breast cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic breast cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.