Clinical trials
Advanced or Metastatic Breast Cancer clinical trials
Below are recruiting advanced or metastatic breast cancer clinical trials, each written for real people, not researchers. We’re tracking 6,202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03836196Recruiting
Improve treatment for advanced prostate cancer with careful planning
This study looks at how to best plan and deliver treatment for men with advanced local prostate cancer. It may help find the most effective approach while keeping side effects manageable.
Vancouver, British ColumbiaAges 18 years+ - NCT03853733Recruiting
Shorter radiation plan for non-surgery rectal cancer
This trial looks at a shorter radiation schedule for people with advanced rectal (or nearby sigmoid) cancer who cannot have surgery. The goal is to control the cancer while keeping treatment simpler, especially for those who cannot safely undergo an operation.
Terrassa, CataloniaAges 18 years+ - NCT03875781RecruitingPhase 3
Chemo before rectal surgery, without pelvic radiation
This Phase 3 study tests whether giving chemotherapy before rectal surgery can work as well as standard treatment that usually includes pelvic radiation. It aims to reduce the need for pelvic radiation while still keeping the cancer under control.
Le Kremlin-Bicêtre, Île-de-France RegionAges 18 years+ - NCT04606914RecruitingPhase 2
Carboplatin plus mirvetuximab for advanced ovarian cancer after chemo
This Phase 2 study tests adding mirvetuximab to carboplatin for people with advanced, high-grade serous ovarian cancer who will first receive “neoadjuvant” chemotherapy. It is designed for tumors that strongly show FRα, which mirvetuximab targets, to see if this improves outcomes.
Birmingham, AlabamaAges 18 years+ - NCT04015609Recruiting
Spanish therapy sessions for Latino people with advanced cancer
This study tests a psychotherapy (talking/support) intervention designed for Latino/Hispanic adults with stage III or IV solid tumor cancer. It uses Spanish-only questionnaires and interviews, and may help by addressing emotional distress during advanced cancer care.
New York, New YorkAges 18 years+ - NCT04282356RecruitingPhase 2
Test of strong chemotherapy delivered inside the abdomen
This Phase 2 trial tests an intensive treatment for advanced ovarian, fallopian tube, or primary peritoneal cancer. It combines planned surgery to remove visible tumor with chemotherapy that is put directly inside the abdomen during the operation, aiming to control the cancer more effectively.
MontpellierAges 18–75 - NCT04406662Recruiting
Study for people living with incurable cancer
This study enrolls adults with advanced, incurable cancer to better understand care and outcomes in everyday settings. It may help by guiding improvements for people receiving treatment for symptom relief (palliative care).
EdinburghAges 18 years+ - NCT04409860Recruiting
Adjuvant chemo after chemoradiation for advanced cervical cancer
This trial looks at whether adding chemotherapy after standard chemoradiation helps people with locally advanced cervical cancer. You may be eligible if your MRI after treatment still shows leftover tumor areas and your health and blood tests are within required limits.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT04410796RecruitingPhase 2
Osimertinib alone or with chemo for EGFR-mutant lung cancer
This trial tests whether osimertinib alone is as good as osimertinib plus chemotherapy for lung cancers that have a specific EGFR mutation. It may help by improving how well the cancer responds and slows growth in people with metastatic non-small cell lung cancer.
Sacramento, CaliforniaAges 18 years+ - NCT04421820RecruitingPhase 1/Phase 2
BOLD-100 with chemo for advanced gut cancer
This Phase 1/2 study tests whether BOLD-100, given with the standard chemo combination FOLFOX, can help people with advanced gastrointestinal cancers. It’s especially focused on specific tumor features (including BRAF status) and checks safety, dosing, and early signs of effectiveness.
Santa Monica, CaliforniaAges 18 years+ - NCT04428528Recruiting
Ultrasound-like pictures that track breast tumors during chemotherapy
This study uses a special light-based imaging scan to learn more about breast masses and how tumors may respond to chemotherapy before surgery. The scan is meant to help doctors better characterize tumors and potentially track treatment response.
Toronto, OntarioAges Any age - NCT04429542RecruitingPhase 1
Test of an EGFR-targeting drug for advanced solid cancers
This Phase 1 study tests the safety of BCA101 (an EGFR-targeting treatment) alone or combined with pembrolizumab. It may help people with certain EGFR-driven advanced cancers, depending on the tumor type, prior treatments, and required biopsy testing.
La Jolla, CaliforniaAges 18 years+ - NCT04680260RecruitingPhase 2
Personalized follow-up after limited surgery or radiation for colon cancer
This Phase 2 study tests the best way to choose and then follow treatment when colorectal cancer has spread only to a small number of spots. You may be eligible if your doctors can remove or precisely treat the spots and there’s no sign of additional spread on scans.
Aarhus NAges 18 years+ - NCT04843215Recruiting
Surgery comparison for advanced stomach cancer after initial surgery
This trial studies whether removing all of the fatty lining (omentum) or only part of it during surgery leads to better outcomes in people with advanced stomach cancer. It also checks that participants can safely have the same stomach-cancer chemotherapy plan after surgery.
Tianjin, Tianjin MunicipalityAges 18–70 - NCT04924075RecruitingPhase 2
Belzutifan for cancers linked to VHL or HIF-2α changes
This Phase 2 study tests belzutifan (MK-6482) to treat certain advanced cancers caused by specific gene or disease changes, including VHL-related tumors and HIF-2α related tumors. It may help shrink tumors or slow their growth in people whose cancer matches these genetic or disease patterns.
Los Angeles, CaliforniaAges 12 years+ - NCT04930432RecruitingPhase 1/Phase 2
MCLA-129 for advanced EGFR- and MET-positive lung and other cancers
This early-phase trial tests MCLA-129, an antibody that targets EGFR and MET, in people with advanced cancers that have specific lab “biomarker” results. It’s for patients whose cancer has grown after standard treatments or can’t take standard treatment, with the goal of shrinking tumors and improving symptoms.
BaodingAges 18 years+ - NCT04960839Recruiting
Preventive radiation to the other breast after breast cancer surgery
This study looks at whether “preventive” radiation to your other (opposite) breast can lower the chance of future breast cancer in people at higher genetic risk. You must have had surgery for early-stage breast cancer and agree to avoid removing the other breast and ovaries.
Jiangxi, JiangxiAges 30–70 - NCT04974346RecruitingPhase 3
Radiation to prevent spread in cervical cancer lymph nodes
This Phase 3 trial tests whether adding a preventive radiation treatment to lymph node areas near the abdomen helps stop cervical cancer from spreading. It aims to improve outcomes for people with certain cervical cancer stages and lymph node results on PET-CT.
Hangzhou, ZhejiangAges 18–75 - NCT05148767RecruitingPhase 4
UGT1A1-guided irinotecan for locally advanced rectal cancer
This trial studies whether adjusting irinotecan treatment based on a person’s UGT1A1 gene test can improve outcomes for locally advanced rectal cancer. It focuses on people who are about to start (or continue) chemoradiation and do not have cancer spread to distant organs.
Hangzhou, ZhejiangAges 18–75 - NCT05173272RecruitingPhase 3
Immunotherapy plus chemo, then radiation, for advanced cervical cancer
This study tests whether adding immunotherapy to chemotherapy, then giving chemotherapy together with radiation, works better for advanced cervical cancer. It aims to improve cancer control and help people live longer, without major safety issues.
Chengdu, SichuanAges 18 years+ - NCT05200260RecruitingPhase 2
Surgery plus maintenance medicines for advanced ovarian cancer
This trial checks whether having surgery to remove as much tumor as possible, followed by ongoing targeted treatment, helps people with advanced ovarian (and related) cancers live longer and/or control cancer better. It specifically uses tumor-testing results to match patients and then continues treatment after surgery.
FoshanAges 18 years+ - NCT05254171RecruitingPhase 2/Phase 3
Trial adds SBP-101 to standard chemo for pancreatic cancer
This trial studies whether adding SBP-101 to standard chemotherapy (gemcitabine plus nab-paclitaxel) can improve outcomes in people with metastatic pancreatic cancer. You may be eligible if you have not yet started treatment for metastatic disease and meet other health and test requirements.
Hot Springs, ArkansasAges 18 years+ - NCT05258448Recruiting
Chemo-radiotherapy for advanced, non-surgical lung cancer
This trial studies treatment that combines chemotherapy and radiation for people with advanced lung cancer that cannot be removed with surgery. It may help improve cure chances for patients who can complete the study tests, including heart scans.
Odense CAges 18 years+ - NCT05263050RecruitingPhase 2
Trial tests a new cabozantinib schedule for kidney and neuroendocrine tumors
This Phase 2 study tests a different dosing schedule of cabozantinib (a cancer medicine) for metastatic kidney cancer and certain neuroendocrine tumors. It aims to see if the timing and schedule can work well for people with advanced disease.
Philadelphia, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for advanced or metastatic breast cancer?
- Yes. Clin2 currently lists 6,202 recruiting advanced or metastatic breast cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic breast cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic breast cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.