Clinical trials
Breast cancer clinical trials
Cancer that forms in the cells of the breast, the most common cancer in women. We’re tracking 2,417 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06309290Recruiting
Prehabilitation with strength training before breast cancer treatment
This trial tests if strength exercises before starting chemotherapy can help postmenopausal women with breast cancer. It aims to improve patients' ability to undergo treatment and surgery.
SantiagoAges Any age - NCT06189209RecruitingPhase 2
Tenalisib for metastatic triple-negative breast cancer
This trial tests a drug called Tenalisib in people with metastatic triple-negative breast cancer who have already tried 1 to 3 chemotherapy treatments. It aims to see if Tenalisib can help shrink tumors and improve outcomes.
Vijayawada, Andhra PradeshAges 18 years+ - NCT06167694RecruitingPhase 1/Phase 2
Study of HRS-8080 and Dalpiciclib for advanced breast cancer
This trial tests a new combination of two drugs (HRS-8080 and Dalpiciclib) for women with advanced breast cancer that cannot be removed by surgery. It may be an option if you have already tried hormone therapy or are starting advanced treatment for the first time.
Beijing, Beijing MunicipalityAges 18–75 - NCT06103864RecruitingPhase 3
Study of Dato-DXd with or without durvalumab for advanced triple-negative breast cancer
This trial is testing whether a new drug combination (Dato-DXd with or without durvalumab) works better than standard chemotherapy plus pembrolizumab for people with a certain type of advanced triple-negative breast cancer that has a protein called PD-L1. The study aims to find a more effective treatment option for this specific group.
Daphne, AlabamaAges 18 years+ - NCT05890677Recruiting
Surgery versus conservative care for chronic breast-related arm swelling
This trial compares microsurgery to standard conservative therapy for long-lasting arm swelling caused by prior breast cancer. It may help people who still have swelling despite months of decongestive treatment by improving quality of life.
New Haven, ConnecticutAges 18 years+ - NCT05806060RecruitingPhase 3
Targeted first treatment for a rare TNBC subtype with spread
This Phase 3 trial tests a more precise treatment strategy for a specific rare type of triple-negative breast cancer (TNBC) called the BLIS subtype. It’s for people whose cancer has spread or cannot be fully removed and who have not had chemo or targeted therapy for metastatic TNBC yet.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05076682RecruitingPhase 2
Study for hard-to-treat triple-negative breast cancer that keeps growing
This Phase 2 trial tests a treatment plan for triple-negative breast cancer that has come back or kept progressing after prior immunotherapy (sometimes along with targeted therapy or chemotherapy). It may help by trying to make the cancer more controllable when it has become resistant to earlier treatment.
ShanghaiAges 18–70 - NCT05763641Recruiting
Targeted treatment after chemo for certain breast cancers
This trial studies an additional treatment given after chemotherapy for locally advanced breast cancer that has spread to specific underarm lymph nodes. It may help some people reduce cancer returning, especially when tumors match certain growth and spread features.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT05654246Recruiting
ShareForCures breast cancer support and research program
This trial is for adults with breast cancer (or suspected breast cancer) who can take part in an English-language program in the United States. It aims to understand and improve outcomes for people affected by breast cancer.
Dallas, TexasAges 18 years+ - NCT05386719Recruiting
Cardiometabolic screening for people after early breast cancer
This trial tests a screening program to look for heart- and metabolism-related health risks in people who have completed treatment for early breast cancer. It may help catch problems earlier so you can get timely care.
Baltimore, MarylandAges 18 years+ - NCT05306041RecruitingPhase 2
Pre-surgery hormone therapy with or without PI3K inhibitor
This trial tests whether giving hormone-blocking treatment before surgery works better when combined with an added targeted drug for certain breast cancers. It may help shrink the tumor and improve outcomes for people whose tumors have specific hormone and genetic features.
Essen, North Rhine-WestphaliaAges 18 years+ - NCT05245812Recruiting
Robotic nipple-sparing mastectomy safety and feasibility study
This trial looks at whether a robotic technique for nipple-sparing mastectomy is safe and practical to do. It may help your care team understand whether this approach works well for people who are candidates for nipple-sparing surgery.
Dallas, TexasAges 18–80 - NCT05187832RecruitingPhase 1
Study drug for ER-positive, HER2-negative breast cancer in postmenopausal women
This Phase 1 trial tests AND019, a new study drug, in postmenopausal women with advanced or metastatic ER-positive and HER2-negative breast cancer. It aims to see if the drug is safe and can control the cancer when other standard treatments have stopped working.
Nashville, TennesseeAges 18 years+ - NCT05007379Recruiting
Testing new immune cells on breast cancer samples in the lab
This trial studies whether newly made immune cells (“CAR-macrophages”) can attack breast cancer when tested on your tumor samples grown in the lab (“organoids”). If you need surgery or a tumor biopsy as part of your usual care, your sample may be used to test this approach.
LilleAges 18–100 - NCT04985058Recruiting
Study of abemaciclib plus hormone therapy in breast cancer
This study uses real-world health records to learn about outcomes in people with hormone-receptor positive, HER2-negative breast cancer who were treated with abemaciclib along with hormone (endocrine) therapy. It may help doctors better understand how well this treatment works outside of clinical trials.
AthensAges 18 years+ - NCT04852887RecruitingPhase 3
Testing shorter breast radiation after low-risk hormone breast cancer
This Phase 3 trial studies whether “less intense” radiation can work as well as standard radiation for certain early-stage hormone receptor–positive, HER2-negative breast cancers that have a low Oncotype DX score. It may help reduce treatment burden while keeping cancer control strong.
Birmingham, AlabamaAges 50–70 - NCT04751435Recruiting
Genetic testing education for cancer patients of diverse backgrounds
This study tests new educational materials about genetic testing for cancer patients. It aims to find the best ways to explain genetic testing to people from different backgrounds, especially Black, Latino, and non-Latino non-Black communities.
Brooklyn, New YorkAges 18 years+ - NCT04638725Recruiting
Genetics study to find why HER2 breast cancer treatment varies
This study looks at genetic factors to understand why some people’s HER2-positive breast cancer responds better—or has more side effects—after treatment. Your info and possible past treatment history may help researchers improve how HER2 treatment is chosen and managed.
StrasbourgAges 18 years+ - NCT03275311Recruiting
Care approach changes for metastatic breast cancer
This trial looks at how treatment care for metastatic breast cancer has evolved over time. You may be eligible if you are an adult receiving active cancer treatment in a comprehensive cancer center in France.
AngersAges 18 years+ - NCT01530373RecruitingPhase 2
Solifenacin vs clonidine to reduce breast cancer hot flashes
This trial compares two medicines—solifenacin and clonidine—to see which one better reduces hot flashes in people taking hormone-blocking cancer medicines. If you have frequent hot flashes, joining could help researchers find an effective option for symptom relief.
Little Rock, ArkansasAges 18 years+ - NCT05341492RecruitingEarly Phase 1
CAR-T therapy for EGFR/B7H3-positive lung and triple-negative breast cancer
This early-phase trial tests CAR-T cells designed to find and attack tumors that show EGFR or B7H3 markers. It may help people with advanced lung cancer or triple-negative breast cancer after standard treatments.
Guangzhou, GuangdongAges 18–75 - NCT07084519RecruitingPhase 3
Short vs standard radiation after mastectomy with implant reconstruction
This trial compares standard radiation therapy to a shorter course (hypofractionated) for women who have had a mastectomy with implant reconstruction. The goal is to see if the shorter schedule works as well while possibly reducing side effects for the reconstructed breast.
Beijing, ProvinceAges 18–75 - NCT07299812Recruiting
Protecting the heart during breast cancer radiation
This trial tests whether a special breathing technique (called Active Breathing Coordinator) can help keep radiation away from the heart while treating breast cancer with radiation therapy. If you can hold your breath briefly during treatment, this might lower the risk of heart damage.
Pavia, LombardyAges 18 years+ - NCT03144648Recruiting
Study of breast cancer subtypes in premenopausal women in Latin America
This study looks at different biological “subtypes” of breast cancer in women who are still having periods. It helps researchers understand the cancer type and may guide more personalized care in the future.
BarretosAges 20–45
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Common questions
- Are there clinical trials for breast cancer?
- Yes. Clin2 currently lists 2,417 recruiting breast cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.