Clinical trials
Cancer (With or Without Metastasis) clinical trials
Below are recruiting cancer (with or without metastasis) clinical trials, each written for real people, not researchers. We’re tracking 13,042 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05333523RecruitingPhase 3
Personalized neck radiation using a lymph node sentinel biopsy
This Phase 3 trial tests whether guiding neck radiation by checking the “sentinel” lymph node can target treatment more precisely in certain larynx, hypopharynx, or oropharynx cancers. It aims to improve control while potentially reducing unnecessary radiation to areas that don’t need it.
AmsterdamAges 18 years+ - NCT05886036RecruitingPhase 2
Comparing rituximab vs mosunetuzumab for NLPHL
This trial compares two immunotherapy drugs, rituximab and mosunetuzumab, to see which works better for people with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) who need treatment. It's for both newly diagnosed and previously treated patients.
Duarte, CaliforniaAges 18 years+ - NCT05907759RecruitingPhase 2
Daratumumab for HIV-related lymphomas and Castleman disease
This trial tests a drug called daratumumab for people with certain HIV-related blood cancers (primary effusion lymphoma, plasmablastic lymphoma) or a related condition called multicentric Castleman disease that has come back or not improved after standard treatment. The drug targets a protein on cancer cells to help the immune system attack them. It might be a new option when standard chemotherapy isn't working or isn't suitable.
Bethesda, MarylandAges 18–120 - NCT05886049RecruitingPhase 1
Testing a menin drug with standard chemo for newly diagnosed AML
This early-phase study tests a menin inhibitor drug (SNDX-5613) combined with standard induction chemotherapy (daunorubicin plus cytarabine) in newly diagnosed AML with specific gene changes (NPM1 or FLT3 status, or MLL/KMT2A or NUP98). It may help patients whose AML has these genetic features respond better to intensive treatment.
Orange, CaliforniaAges 18–75 - NCT05903950Recruiting
Air pollution study to help lower blood pressure
This trial tests whether an air-pollution–reduction approach in your home can help lower blood pressure. It focuses on adults with mildly high blood pressure and certain metabolic health markers.
DohaAges 18–60 - NCT05903131RecruitingPhase 2
Lifestyle program to help keep the uterus in early cancer
This Phase 2 study tests whether a lifestyle transformation can help treat complex atypical endometrial hyperplasia or early (grade 1) endometrial cancer without removing the uterus. It may help support uterine preservation for people who want to keep fertility or avoid hysterectomy.
St Louis, MissouriAges 18 years+ - NCT05885048Recruiting
Testing how cancer treatments affect future fertility
This study looks at how treatments that can harm ovaries or testicles (like certain chemotherapy, radiation, and immune therapies) may affect fertility. It may help you and others by measuring hormone levels (and in some cases sperm) before and during/after treatment.
BernAges 14–50 - NCT05879146RecruitingPhase 2
Nirogacestat for desmoid tumors with tumor growth monitoring
This Phase 2 study tests nirogacestat (a targeted medicine) in people with desmoid tumors that are growing. It also studies how tumors respond—or don’t respond—by using repeated tumor scans and sometimes repeated tumor biopsies.
Houston, TexasAges 18 years+ - NCT05879211Enrolling by invitation
Care learning lab for Duke Health patients
This trial is a “learning laboratory” that studies how best to provide goal-focused care. It may help improve care experiences for Duke Health patients, based on what the study learns.
Durham, North CarolinaAges 18 years+ - NCT05893940Recruiting
Gentle physical stimulation during blood cancer transplant
This trial tests whether a low-intensity mechanical (physical) stimulation is safe and helpful for people with certain blood cancers who are about to have a transplant. It may affect how you do during or after treatment, and participation is voluntary with informed consent.
Buffalo, New YorkAges 18 years+ - NCT05907694Recruiting
Treatment of stroke from PFO, with or without closure
This study looks at whether treating a history of “cryptogenic” stroke (stroke with no clear cause) using a patent foramen ovale (PFO) closure, plus medical therapy, is better than medical therapy alone. It focuses on people over 60 with a heart shunt seen on an ultrasound of the heart.
Québec, QuebecAges 18 years+ - NCT05905146Recruiting
Personalized opioid plan to shorten treatment time
This trial tests whether a personalized medication plan can help patients with short-term, non-cancer muscle or joint pain need strong opioid medicine for a shorter time. It’s aimed at improving how long treatment lasts while still managing pain.
LilleAges 18 years+ - NCT05909501Recruiting
Study of geriatric checkups for new AML treatment plans
This study looks at whether geriatric (age-related health) evaluations help doctors choose better treatment for newly diagnosed AML (a type of leukemia). It may help translate older adults’ needs into a clearer, safer treatment plan.
Philadelphia, PennsylvaniaAges 50 years+ - NCT05893888RecruitingPhase 2/Phase 3
Testing three investigational drugs for mouth and lung cancers
This trial tests whether PRV111, PRV211, and PRV131 are safe and work better than expected for certain mouth (lip/oral cavity) cancers and lung cancers. It may help by trying a new approach given directly to the tumor and then monitoring how well it shrinks and how safe it is.
Duarte, CaliforniaAges 18–100 - NCT05873231Recruiting
Gut microbiome study for diarrhea after anti-cancer treatment
This trial looks at how changes in the gut (microbiome) relate to diarrhea that can happen after starting anti-cancer therapy. It may help doctors better predict and manage treatment-related diarrhea.
GrazAges 18 years+ - NCT05875870Recruiting
Bright light and exercise program for lung or esophageal cancer
This trial tests whether a structured bright-light exposure routine combined with a specific exercise program can help people with newly diagnosed lung or esophageal cancer. You may be eligible if you’re in early-to-middle cancer stages and able to safely participate in walking-based activities.
Taipei City, TaipeiAges 20 years+ - NCT05862285RecruitingPhase 3
Rollover trial for people already on Roche study treatment
This is a “rollover” study for people who were already taking a Roche (or Genentech) cancer study medicine. It checks whether continuing the same study treatment (when commercial options aren’t available) can keep helping you.
CharleroiAges Any age - NCT05855200RecruitingPhase 3
Dostarlimab around surgery for certain untreated colon cancers
This trial studies dostarlimab given around the time of colon cancer surgery for people with untreated, resectable (operable) stage T4N0 or stage III colon cancer that has specific tumor markers. It may help shrink or eliminate the cancer before or after surgery by boosting the immune response.
Tucson, ArizonaAges 18 years+ - NCT05865535RecruitingPhase 1
Dose study of AV-380 for cancer-related weight loss
This Phase 1 trial tests a new drug (AV-380) in people with solid tumor cancer who are losing weight and muscle because of cancer. It mainly helps researchers find a safe dose and see how the body responds, and it may offer a new option for cancer-related cachexia.
Beverly Hills, CaliforniaAges 18 years+ - NCT05877456Enrolling by invitation
Checking a polyp-removal scoring tool for doctors
This study tests and confirms a scoring tool (GPAT) that helps describe how well doctors perform polyp removal during endoscopy. It may help standardize training and assessment, which can improve consistency in care.
Ghent, GentAges 18–100 - NCT05851924RecruitingPhase 2
Nalirifox plus radiation for nonmetastatic pancreatic cancer
This trial studies Nalirifox (chemotherapy) given together with radiation therapy for pancreatic ductal adenocarcinoma that has not spread to distant organs. It may help shrink the cancer and improve local control, especially when surgery is not an option right now.
Basking Ridge, New JerseyAges 18 years+ - NCT05852990RecruitingPhase 3
Gut help to prevent diarrhea from EGFR-targeted lung cancer drugs
This Phase 3 trial tests whether adding glutamine plus L. reuteri can help prevent severe diarrhea caused by EGFR-targeted treatments in people with advanced non-small cell lung cancer. If it works, it could make treatment easier to tolerate and help you stay on the planned therapy.
Mexico City, Mexico CityAges 18–80 - NCT05849155Recruiting
Talking study for teens with inherited cancer risk
This study looks at how parents and children communicate after learning about an inherited (genetic) cancer risk. It may help researchers find better ways to support families in these conversations.
Memphis, TennesseeAges 10–24 - NCT05848557Recruiting
Mobile app study for cervical cancer screening and education
This study tests a mobile health tool (an app) and related surveys to improve knowledge and screening awareness for cervical cancer, including HPV risk and acceptability. It involves people working in cervical cancer screening and women in specific communities, with participation based on consent and eligibility for screening.
Kisumu, Kisumu CountyAges 18 years+
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Common questions
- Are there clinical trials for cancer (with or without metastasis)?
- Yes. Clin2 currently lists 13,042 recruiting cancer (with or without metastasis) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cancer (with or without metastasis) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cancer (with or without metastasis) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Liver Metastasis Colon Cancer
- Gastric Cancer, Gastroesophageal Junction Cancer
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Colorectal Cancer Liver Metastasis
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Leptomeningeal Metastasis of Breast Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.