Cardiovascular clinical trials

Heart Health in Pregnancy After Frozen Embryo Transfer

This study looks at how the heart and blood vessels adjust during pregnancy in women who became pregnant after a frozen embryo transfer (FET) using IVF. It aims to understand if different types of FET cycles affect maternal health, and may help improve future fertility care.

Long-term follow-up for a gene editing heart therapy

This study follows people who already received an experimental gene editing treatment for cardiovascular disease in a prior Verve trial. The goal is to monitor their health and any long-term effects over time.

Studying how body stress signals affect sleep and heart health

This study looks at how “stress signals” in the body after an injury may affect sleep and cardiovascular (heart and blood vessel) health. It may help researchers understand what contributes to recovery and how to improve outcomes for wounded service members.

Study linking adult oral health, social factors, and heart health

This study looks at how people’s oral health in adulthood relates to social factors and heart health. To join, you must have already taken part in specific past health surveys.

CT heart scan trial to prevent first heart problems

This trial uses a special CT scan of the heart’s arteries to better predict who is at risk of future heart problems. It may help your care team decide how best to lower risk early.

Probacine to protect organs after cardiovascular surgery

This study tests whether a medicine called Probacine can help protect your gut and organs after cardiovascular surgery. If you qualify, you may be asked to take part and follow the study plan to see if complications are reduced.

Study following ovarian aging and heart risk

This study follows people who were already enrolled in the original OVA study, to track how ovarian aging may affect long-term heart health. It can help doctors understand which risks change over time and why.

Air pollution study to help lower blood pressure

This trial tests whether an air-pollution–reduction approach in your home can help lower blood pressure. It focuses on adults with mildly high blood pressure and certain metabolic health markers.

Testing AI to find hidden heart conditions from ECGs

This study uses an AI tool to look at your ECG (a simple heart test) to help find early signs of atrial fibrillation (an irregular heartbeat) or structural heart disease (changes in heart structure). It aims to see if the AI can help doctors catch these conditions sooner, even in people who don't yet have symptoms.

Testing a new PET scan to detect lung and heart scarring

This study tests a new imaging scan (called 18F-FAPI PET/CT) that may help detect scarring in the lungs, heart, or blood vessels. If you have a heart, lung, or blood vessel condition that could cause scarring, this scan might show damage earlier and help doctors plan better treatment.

Twenty-four Hour Movement Behaviors and Atherosclerotic Risk

The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

Vesalius TMVr system for leaky heart valve (mitral regurgitation)

This study tests a new device called the Vesalius TMVr system to fix a leaky mitral valve without open-heart surgery. It's for people with severe mitral regurgitation who are not good candidates for surgery.

Free healthy groceries to help lower blood pressure

This study gives people with high blood pressure free healthy groceries for 4 weeks to see if eating better can lower their blood pressure. It might help you get your blood pressure into a healthier range.

Phone-based coaching to help overweight Black women improve heart health

This study tests a mobile app (phone-based program) to help overweight or obese African American women improve weight and cardiovascular (heart) health. You’ll also use a wrist activity monitor, and you may be offered optional MRI scans for extra measurements.

Heart pump support for severe heart failure

This study tests a device that helps the heart pump blood when it is too weak to do so, even with medicine, after surgery, or while waiting for a transplant. It aims to see if it's safe and works well.

Factors affecting drug-coated balloon restenosis

This study looks at why some drug-coated balloons (used to open blocked heart arteries) might narrow again after treatment. If you have coronary artery disease and are scheduled for this procedure, you may be eligible to help researchers understand what factors affect the balloon's success.

Nerve ablation for pulmonary hypertension from left heart disease

This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.

Inclisiran to prevent heart and leg events after artery procedure

This study tests whether a twice-yearly injection called inclisiran can prevent heart attacks, strokes, or leg complications in people who recently had a procedure to open a blocked artery. You may be eligible if you had a heart or leg artery procedure within the last two weeks.

AI heart health program for young adults

This study tests if an AI-powered system can help manage premature coronary artery disease in adults aged 18 to 45. It uses a smartphone app to support treatment and improve outcomes.

Testing BrioVAD heart pump for severe heart failure

This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.

Tricuspid valve replacement using a new catheter device

This trial tests a new device that replaces a leaky tricuspid valve (a heart valve) without open-heart surgery. If your tricuspid valve isn't working well and medicines haven't helped enough, this procedure might improve your heart function and symptoms.

Heart health in young athletes over 3 years

This study follows young athletes over three years to see how their hearts adapt to regular training. Researchers will use yearly checkups to learn more about heart health in active kids and teens.

Looking inside heart arteries to improve stent placement

This study tests a new imaging technique to help doctors see inside your heart arteries during a stent procedure. It may help guide treatment and improve outcomes for people with heart disease.