Clinical trials
Chemotherapy clinical trials
Below are recruiting chemotherapy clinical trials, each written for real people, not researchers. We’re tracking 2,011 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04453826RecruitingPhase 3
Test PD-1 plus chemo-radiation for high-risk nasopharyngeal cancer
This Phase 3 trial tests whether adding a PD-1 immunotherapy (given with chemotherapy and radiation, and also after) can improve outcomes for people with high-risk nasopharyngeal cancer. It may help by strengthening the immune system’s attack on the cancer alongside standard treatment.
Guangzhou, GuangdongAges 18–70 - NCT04453813RecruitingPhase 3
Immunotherapy with chemoradiation for recurring nasopharyngeal cancer
This phase 3 trial tests whether adding toripalimab (an immunotherapy medicine) to standard chemo-radiation works better for treating nasopharyngeal cancer that has come back and cannot be removed by surgery. It aims to improve control of the cancer after it returns.
Guangzhou, GuangdongAges 18–70 - NCT04453904Recruiting
Testing best added chemo and radiation after stage III uterine cancer
This study compares different ways of giving radiation and chemotherapy after surgery for stage III endometrial (uterine) cancer. It aims to find which approach works best to reduce cancer risk and improve outcomes.
Beijing, Beijing MunicipalityAges Any age - NCT04464122Recruiting
Testing blood markers to diagnose and gauge early response in NEN
This trial studies whether specific blood “biomarkers” can help confirm a type of cancer called NEN (neuroendocrine neoplasm) and show whether treatment is working early. It may help doctors start or adjust treatment sooner, especially for cancers that are advanced or have spread.
Rome, ItalyAges 18–80 - NCT04474964Recruiting
Radiotherapy plus chemo for WNT medulloblastoma in children
This study tests whether adding a specific brain/spinal radiation plan (focused radiation plus low-dose spinal coverage) followed by chemotherapy works well for children with newly diagnosed WNT medulloblastoma after surgery. It targets kids whose remaining tumor after surgery is small and who have no spread to the spine or fluid.
Mumbai, MaharashtraAges 3–16 - NCT04486833RecruitingPhase 1/Phase 2
Genetic-targeted drug plus gene medicine for EGFR lung cancer
This trial studies a gene-based treatment added to osimertinib (a targeted lung cancer pill) for advanced EGFR-mutant lung cancer that has started growing again on osimertinib. It may help by attacking the cancer with both its usual target treatment and an added genetic approach.
Los Angeles, CaliforniaAges 18 years+ - NCT04495088RecruitingPhase 3
Before vs after chemotherapy for locally advanced rectal cancer
This Phase 3 study compares giving chemotherapy before rectal surgery versus giving it after surgery, using a tailored plan based on your risk. The goal is to see which timing helps more people with locally advanced rectal cancer stay cancer-free and live longer.
MannheimAges 18 years+ - NCT04499053RecruitingPhase 2
Durvalumab and tremelimumab with chemotherapy for advanced lung cancer in HIV
This trial tests a combination of immune therapy drugs (durvalumab and tremelimumab) given with chemotherapy in people with stage IV non-small cell lung cancer who also have HIV. It may help shrink or control cancer by boosting the immune response while keeping HIV well controlled.
Washington D.C., District of ColumbiaAges 18 years+ - NCT04520074RecruitingPhase 3
Chemo after surgery for BRCA1/2 wild-type ovarian cancer
This Phase 3 trial studies a three-step “extra” chemotherapy plan after surgery for people with certain advanced ovarian, fallopian-tube, or primary peritoneal cancers. The goal is to improve outcomes by lowering the chance the cancer comes back.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04522687Recruiting
Blood lymphocyte changes studied during radiation and chemotherapy for lung cancers
This study looks at how a type of white blood cell in your blood changes while you receive radiation and chemotherapy. The goal is to see whether these blood changes relate to treatment, especially in certain chest (thoracic) cancers.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT04539977RecruitingPhase 2
PD-L1 antibody plus chemotherapy for limited-stage small-cell lung cancer
This Phase 2 study tests whether adding a PD-L1 antibody to chemotherapy helps people with newly diagnosed limited-stage small-cell lung cancer live longer and control the cancer better. It may benefit patients who have not had any prior cancer treatment for SCLC and can meet health and lab requirements.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04543071RecruitingPhase 2
Second-line-like immunotherapy and chemo for metastatic pancreatic cancer
This Phase 2 trial studies a combination of immunotherapy, a blood-vessel/immune signal blocker, and chemotherapy for people with metastatic pancreatic adenocarcinoma. It may help shrink tumors and improve control of the disease.
New York, New YorkAges 18 years+ - NCT04547166RecruitingPhase 2/Phase 3
New targeted immune drug plus bevacizumab and chemo for colon cancer
This trial studies serplulimab (an immune-related drug) together with bevacizumab and chemotherapy to treat metastatic colorectal (colon) cancer that cannot be removed with surgery. It aims to see whether this combination improves outcomes and is safe.
Guangzhou, GuangdongAges 18–75 - NCT04583254RecruitingPhase 2
Shorter radiation plan for certain early cervical cancers
This trial tests a feasibility (“can it be done safely?”) approach that delivers radiation in a shorter schedule for some cervical cancer patients. It also uses weekly cisplatin chemotherapy and includes a radiation procedure called brachytherapy to improve treatment effectiveness.
Kelowna, British ColumbiaAges 18 years+ - NCT04588168Recruiting
MRI helps guide bladder cancer treatment planning
This trial uses special MRI scans to help doctors choose precise treatment for bladder cancer before and/or around surgery. It may help tailor therapy more accurately while you receive standard bladder cancer care.
Nanjing, JiangsuAges 18 years+ - NCT04616131Recruiting
Testing ctDNA as a marker in pancreatic cancer treatment
This trial is studying a blood test that looks for tumor DNA (ctDNA) to see if it can help predict how well treatment is working in people with pancreatic cancer that hasn't spread. It is for patients getting chemotherapy before possible surgery.
DeKalb, IllinoisAges 18 years+ - NCT04616300Recruiting
Exercise program to support brain function during breast cancer chemo
This trial studies whether a structured exercise program can help protect or improve thinking and memory in people with breast cancer while they are starting chemotherapy after surgery. It may help with “chemo brain” by targeting brain function during treatment.
Toronto, OntarioAges 18–65 - NCT04617756RecruitingPhase 2
Durvalumab plus chemo before surgery for high-risk upper urinary tract cancer
This trial studies whether durvalumab (an immunotherapy) given with chemotherapy before surgery can improve outcomes for people with high-risk cancer in the kidney pelvis or ureter. It is mainly looking at safety and effectiveness in shrinking or controlling the cancer before treatment continues.
Paris, Paris Cx 20Ages 18 years+ - NCT04620187RecruitingPhase 2
Study medicine T-DM1 after surgery for HER2-positive salivary cancer
This Phase 2 trial studies T-DM1 given after surgery for salivary gland cancer that is HER2-positive. The goal is to reduce the risk of the cancer coming back by targeting HER2-positive tumor cells.
Atlanta, GeorgiaAges 18 years+ - NCT04623931RecruitingPhase 2
Chemo and radiation for IDH-wildtype glioma
This Phase 2 study tests a combination of chemotherapy and radiation after surgery for certain brain tumors that are “IDH wildtype.” It aims to control the tumor and improve outcomes for people with specific types of glioma or glioblastoma.
Houston, TexasAges 18 years+ - NCT04638790RecruitingPhase 3
First treatment chemotherapy study for newly diagnosed Hodgkin lymphoma
This trial studies the best first chemotherapy approach for people newly diagnosed with classical Hodgkin lymphoma. It may help improve outcomes by comparing how treatment is given in routine care settings in Russia.
Mumbai, Opd-81 Main Building, Dr. E Borges Road, Parel 400012Ages 18–50 - NCT04652609Recruiting
Exercise program to prevent nerve damage from chemotherapy
This trial studies an exercise program (PRESIONA) that may help prevent nerve pain or numbness caused by a common type of breast cancer chemotherapy called taxane-based treatment. It targets people with HER2-positive breast cancer who are about to start neoadjuvant chemotherapy.
GranadaAges 18–70 - NCT04659616RecruitingPhase 1
Pemigatinib after standard chemo for newly diagnosed AML
This Phase 1 trial studies whether adding pemigatinib after standard “7+3” chemotherapy can improve outcomes in certain newly diagnosed acute myeloid leukemia (AML) patients. It aims to find a safe dose and see how well the drug works in a very specific AML genetic group.
Portland, OregonAges 18 years+ - NCT04671667RecruitingPhase 2
Pembrolizumab vs chemo-radiation after surgery for recurrent head/neck cancer
This trial tests whether pembrolizumab (an immunotherapy drug) works better than the usual chemo plus radiation after surgery for cancer that has come back in the head and neck area. It may help reduce cancer returning or spreading by using your immune system, but eligibility depends on how the cancer came back and your prior treatments.
Birmingham, AlabamaAges 18–79
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Common questions
- Are there clinical trials for chemotherapy?
- Yes. Clin2 currently lists 2,011 recruiting chemotherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chemotherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chemotherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.