Clinical trials
Chronic Headache clinical trials
Below are recruiting chronic headache clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06674772Recruiting
Migraine study measuring CGRP levels by age and sex
This study measures a substance called CGRP in saliva from people with migraine and healthy volunteers to see how it changes with age and sex. It may help researchers understand migraine better.
Barcelona, BarcelonaAges 6–75 - NCT07113470Recruiting
Nerve stimulation for chronic cluster headache prevention
This trial tests if a device that stimulates nerves on your face and the back of your head can prevent chronic cluster headaches. It may offer a new treatment option if you have had cluster headaches for at least a year.
LeidenAges 18 years+ - NCT05306899RecruitingPhase 3
IV ketamine for chronic daily headaches
This trial tests whether an IV dose of ketamine can reduce chronic daily headaches and is safe for people with this condition. It may help by lowering headache frequency and severity, but it also has several medicine and health-related safety checks.
Toronto, OntarioAges 18–75 - NCT06652724Recruiting
Psychological help for chronic pain in fibromyalgia and migraine
This study looks at how psychological factors and treatments might help with chronic pain in people with fibromyalgia and/or chronic migraine. It compares different groups to understand what works best.
Rome, RMAges 18–50 - NCT06077747Recruiting
Lumbar vein treatment for chronic headaches with nutcracker anatomy
This study tests a procedure called lumbar vein embolization to treat daily headaches that feel like pressure and get worse when lying down. It's for people who have a rare anatomy where a vein in the kidney is pinched (nutcracker physiology), and standard headache medicines haven't helped.
Jacksonville, FloridaAges 18 years+ - NCT07348783Recruiting
Yoga for chronic migraine and cluster headache
This study tests whether yoga-based movements can help reduce headache frequency and improve well-being in people with chronic migraine or cluster headache. You would follow online or in-person yoga instructions at home for several weeks, wear an activity tracker, and provide blood samples.
HuddingeAges 18–65 - NCT07071506Recruiting
New tools to track migraine prevention
This study tests new ways to monitor how well preventive migraine treatments are working. It is for people with chronic migraine who may be starting or already using preventive medications.
Aarhus C, DenmarkAges 18–65 - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT06921109Recruiting
Virtual reality for headache relief in kids
This study tests if using virtual reality to learn relaxation techniques can help reduce headaches in children and teens who have migraines or frequent tension headaches.
Sart Tilman, LiegeAges 8–15 - NCT07268768Recruiting
Personality, thinking, and sensitivity in headache
This study looks at how personality, thinking skills, and heightened nerve sensitivity are connected in people with headache. It aims to better understand these relationships to improve care.
Messina, SicilyAges 18–60 - NCT05415020Recruiting
Behavior program for chronic migraine
This trial tests a behavioral (talk/skills-based) program to help people with chronic migraine. It may help reduce migraine frequency or improve day-to-day coping.
Phoenix, ArizonaAges 18 years+ - NCT03231241Recruiting
Study of worsening headaches using scans and blood testing
This study looks at why headaches can become long-lasting (“chronified”) by combining answers from online questionnaires, brain imaging, and blood protein tests. Your participation may help researchers find biological clues that could improve how headache problems are understood and treated.
Stanford, CaliforniaAges 18 years+ - NCT07719608Recruiting
MySalvia system for resistant migraine
This trial tests a device called MySalvia that is implanted in the head to reduce migraine attacks. It is for people whose migraines have not improved with at least three different preventive treatments.
Newnan, GeorgiaAges 22–84 - NCT07677137Recruiting
Testing a nerve stimulator for hard-to-treat chronic cluster headache
This trial tests a device that uses mild electrical pulses to the nerves at the back of the head to prevent cluster headaches. It is designed for people whose headaches have not responded to multiple standard treatments.
Sint-NiklaasAges 22–70 - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT06684249Recruiting
Comparing nerve block and Botox for chronic migraine
This study compares two treatments for chronic migraine: a nerve block (injection near the nerves in the head) and Botox injections. It aims to see which one works better to reduce headache days and improve quality of life.
Zagazig, Sharqia ProvinceAges 18–65 - NCT06690060Recruiting
Mind-body program for chronic migraine
This study tests whether a mind-body program, done remotely, can help people with chronic migraines reduce headache impact. It is for adults who have migraines at least 5 days a month and are willing to learn relaxation and stress-management techniques.
Boston, MassachusettsAges 18 years+ - NCT07297901Enrolling by invitation
Breathing app study for migraine relief
This trial tests a smartphone-based breathing program to help reduce migraines. It uses heart rate data to guide breathing exercises tailored to you.
Phoenix, ArizonaAges 18 years+ - NCT05477459RecruitingPhase 2
LSD treatment for reducing the burden of cluster headaches
This Phase 2 trial tests LSD to see if it can reduce how much cluster headaches disrupt your life. You may be eligible if your cluster headaches are frequent and steady, and if you meet key safety and mental-health requirements.
LeidenAges 16–75 - NCT06787677Recruiting
SPG pulsed radiofrequency for chronic cluster headache
This trial tests a treatment called sphenopalatine ganglion (SPG) pulsed radiofrequency for people with chronic cluster headache. It uses short bursts of energy to calm a nerve cluster in the face that is linked to the pain, and may help when standard medicines like verapamil or lithium haven't worked.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05620719Recruiting
Study delayed headache after head injury in veterans
This study looks at treatment for ongoing headache that starts or gets worse after a mild or moderate head/neck injury in veterans or active-duty service members. It may help by testing an approach aimed at reducing headache burden and improving daily functioning.
Los Angeles, CaliforniaAges 18–70 - NCT07617441Recruiting
Brain and Psychology Study of Hard-to-Treat Migraines
This research study compares brain structure and psychological traits in people with chronic migraines that don't respond well to standard treatments versus healthy volunteers without migraines. Understanding these differences may help doctors develop better treatment options for difficult-to-treat migraines.
Catanzaro, CatanzaroAges 18–75 - NCT03944876RecruitingPhase 3
Botulinum toxin to block a facial nerve for chronic cluster headaches
This trial tests whether injections of botulinum toxin type A can reduce frequent, severe cluster headache attacks by targeting a facial nerve area. It’s for people whose cluster headaches have not responded well—or have caused side effects—to standard preventive treatments.
HamburgAges 18–85 - NCT06225817Recruiting
Can a placebo help with chronic jaw pain and sleep?
This study is testing whether a placebo (a pill with no medication) can help improve sleep and reduce pain for people with long-term jaw or face pain. Researchers want to see if just expecting relief can change how your body handles pain.
Baltimore, MarylandAges 18–88
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Common questions
- Are there clinical trials for chronic headache?
- Yes. Clin2 currently lists 46 recruiting chronic headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.