Clinical trials
Chronic Headache clinical trials
Below are recruiting chronic headache clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06540651Recruiting
Light therapy for chronic cluster headache
This study tests whether daily light therapy can reduce the number of cluster headache attacks in people with chronic cluster headache. It is a non-drug treatment that uses a special lamp to see if it helps calm your headache cycles.
MarseilleAges 18 years+ - NCT07514208Enrolling by invitation
Headache Sensitivity and Pain Testing Study
This study examines how sensitive the skin and tissues around the head are in people with migraines or tension headaches. Researchers will perform gentle touch and pressure tests to understand pain patterns, which may help improve headache treatment in the future.
Barcelona, BarcelonaAges 18 years+ - NCT06848166RecruitingEarly Phase 1
Middle meningeal artery embolization for resistant chronic migraine
This study tests a procedure called 'middle meningeal artery embolization' using a special glue-like material (SQUID) to treat chronic migraine that hasn't responded to other treatments. The goal is to see if blocking blood flow to the membrane around the brain can reduce migraine attacks.
Bishkek, BishkekAges 35–59 - NCT07223008Recruiting
Bilateral artery embolization for chronic migraine
This trial tests a procedure called bilateral middle meningeal artery embolization to see if it reduces chronic migraine symptoms in people who haven't found relief from other treatments. It's for those with frequent, disabling migraines that affect both sides of the head.
Baltimore, MarylandAges 18–80 - NCT07500558Recruiting
Ultrasound-guided nerve block for chronic migraine pain relief
This study tests two power levels of a pulsed radiofrequency treatment aimed at a nerve cluster behind your cheekbone to reduce chronic migraine pain. If you have frequent migraines that haven't responded well to two or more preventive medications, this could be an option for you.
MinyaAges 20–70 - NCT05337033RecruitingPhase 2
Testing cannabis for chronic headaches in teens
This trial studies whether cannabis can reduce chronic migraine headaches in adolescents who have not improved with other treatments. It also asks participants to work with psychology and physiotherapy during the study.
Vancouver, British ColumbiaAges 14–17 - NCT07347067Recruiting
Trigger point injections for chronic migraine
This study tests if injecting medication into specific painful spots in your muscles (called trigger points) can help reduce chronic migraine pain. It may be an option if you've tried other treatments but still have significant pain.
Beijing, Beijing MunicipalityAges 18–65 - NCT07347730Recruiting
Trigger point injections for chronic headache from the neck
This study tests whether injections into muscle trigger points can reduce chronic headache pain that starts in the neck. It may help people who have not found relief from standard pain medications.
Beijing, Beijing MunicipalityAges 18–65 - NCT07776275Recruiting
Headache study comparing neck pain patients with healthy people
This study looks at physical differences between people with cervicogenic headache (a headache that starts in the neck), people with chronic neck pain without headache, and healthy controls. By comparing these groups, researchers hope to better understand what causes the headache and which physical features are specific to it.
Istanbul, SefaköyAges 25–60 - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT05334927Recruiting
Headache disorder registry for teens and adults with primary headaches
This study is a headache disorder registry that enrolls people with common, “primary” headache types such as migraine or tension headache, including some with medication-overuse headaches. It collects information to better understand these conditions and who they affect.
Anqing, AnhuiAges 12 years+ - NCT07040813RecruitingPhase 3
Two migraine medicines together for chronic migraine
This trial tests whether using both a CGRP antibody and Botox together works better than the CGRP antibody alone for chronic migraine. It may help if you have not tried these treatments before.
GrålumAges 18–70 - NCT05700318Recruiting
Test of a device therapy for frequent migraine
This trial studies a migraine device (the ShiraTronics Migraine Therapy System) to help people with frequent migraine headaches. It may be a good option if you’ve tried common migraine preventions but they didn’t work for you, weren’t safe, or you couldn’t take them.
Broadmeadow, New South WalesAges 22 years+ - NCT07159750Recruiting
Study on new migraine drugs in real life
This study tracks how well new migraine medications (like Aimovig, Emgality, Ajovy, Vyepti, Qulipta, and Nurtec) work in everyday use. It may help you and your doctor understand if these treatments are a good option for your migraines.
Miami, FloridaAges 18 years+ - NCT07166536Recruiting
Study on mental imagery and symptom worsening after concussion
This trial tests whether mental imagery tasks can trigger or worsen headaches and dizziness in people with long-lasting symptoms after a mild traumatic brain injury or concussion. If you still have headaches or dizziness more than 3 months after your injury, this study may help understand how your brain reacts to mental exercises.
Tel AvivAges 18–74 - NCT07103694Recruiting
Migraine drug database study
This study is building a database to learn more about migraine drugs. It may help researchers find better treatments for people with episodic or chronic migraine.
Milan, ItalyAges 18 years+ - NCT05617365RecruitingPhase 1/Phase 2
Study treatment for chronic neck-related head and neck pain
This early-stage study tests a new treatment for people (women) who have long-lasting headaches and pain coming from the neck. It may help reduce symptoms, but you must match specific safety and diagnosis requirements.
East Lansing, MichiganAges 18–65 - NCT05689944Recruiting
Dance therapy for teens with chronic pain
This trial studies whether dance therapy can help reduce chronic pain in teens when usual pain treatments haven’t worked well. It may be helpful if you’re followed in a pain clinic and are able to participate in movement-based sessions.
BronAges 12–20 - NCT05889624Recruiting
Study of treatments for childhood migraine headaches
This study looks at ways to help children and teens with migraine headaches by testing a care approach that includes access to evidence-based treatment. It may help if your child has frequent migraine headaches and is starting (or not already on) certain migraine-preventive medicines.
Birmingham, AlabamaAges 10–17 - NCT04715685Recruiting
Mind-body balance program for children with migraine
This trial studies a mind-body balance approach to help reduce symptoms and disability from pediatric migraine. You may join if your child has migraine headaches and can follow study routines, including keeping a headache diary.
Aurora, ColoradoAges 10–17 - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80 - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65
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Common questions
- Are there clinical trials for chronic headache?
- Yes. Clin2 currently lists 46 recruiting chronic headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.