Clinical trials
Chronic Migraine clinical trials
Below are recruiting chronic migraine clinical trials, each written for real people, not researchers. We’re tracking 58 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07040813RecruitingPhase 3
Two migraine medicines together for chronic migraine
This trial tests whether using both a CGRP antibody and Botox together works better than the CGRP antibody alone for chronic migraine. It may help if you have not tried these treatments before.
GrålumAges 18–70 - NCT06562413Recruiting
Finding New Biological Clues in Hard-to-Treat Migraine
This study looks for new biological markers in people whose migraines don't respond to standard treatments. It aims to better understand why some migraines are hard to treat and may help guide future therapies.
PaviaAges 18–75 - NCT06562400Recruiting
New treatments for resistant migraine
This trial is testing new approaches for people whose migraines haven't improved with multiple preventive treatments. The goal is to find better options for those with hard-to-treat migraine.
PaviaAges 18–75 - NCT04628429Recruiting
Study CGRP blocker effects on migraine and body nerve function
This study tests a CGRP-blocking antibody to see how it affects migraine symptoms and the body’s automatic (involuntary) nerve functions. It may help people with migraine who have already tried several preventive medicines.
ViennaAges 18–64 - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT04715685Recruiting
Mind-body balance program for children with migraine
This trial studies a mind-body balance approach to help reduce symptoms and disability from pediatric migraine. You may join if your child has migraine headaches and can follow study routines, including keeping a headache diary.
Aurora, ColoradoAges 10–17 - NCT05889624Recruiting
Study of treatments for childhood migraine headaches
This study looks at ways to help children and teens with migraine headaches by testing a care approach that includes access to evidence-based treatment. It may help if your child has frequent migraine headaches and is starting (or not already on) certain migraine-preventive medicines.
Birmingham, AlabamaAges 10–17 - NCT07103694Recruiting
Migraine drug database study
This study is building a database to learn more about migraine drugs. It may help researchers find better treatments for people with episodic or chronic migraine.
Milan, ItalyAges 18 years+ - NCT05903027Recruiting
Testing gepant migraine treatment for better side effects
This trial studies how well a “gepant” medicine works for different types of migraine and how tolerable it is. It may help if you have frequent migraines and you can keep a headache diary as the study asks.
FlorenceAges 18 years+ - NCT07348783Recruiting
Yoga for chronic migraine and cluster headache
This study tests whether yoga-based movements can help reduce headache frequency and improve well-being in people with chronic migraine or cluster headache. You would follow online or in-person yoga instructions at home for several weeks, wear an activity tracker, and provide blood samples.
HuddingeAges 18–65 - NCT06461767Recruiting
rTMS for chronic migraine without recent prevention
This study tests whether repetitive transcranial magnetic stimulation (rTMS) — a noninvasive treatment using magnetic pulses on the head — can help prevent and treat chronic migraine pain. It may be an option for people who have never tried or are currently off migraine prevention medicines.
SohagAges Any age - NCT03404336Recruiting
Well-being therapy for chronic migraine in outpatients
This study tests whether a “well-being therapy” program can reduce symptoms of chronic migraine compared with a control therapy. You may qualify if you have long-lasting chronic migraine and can follow the study schedule.
Florence, FlorenceAges 18–65 - NCT03972124RecruitingPhase 2
Cannabis to prevent migraine attacks before they start
This Phase 2 trial tests whether using cannabis can prevent migraine attacks from happening. It specifically looks at people with chronic migraine who have tried and not benefited from other prevention medicines.
Calgary, AlbertaAges 25 years+ - NCT05334927Recruiting
Headache disorder registry for teens and adults with primary headaches
This study is a headache disorder registry that enrolls people with common, “primary” headache types such as migraine or tension headache, including some with medication-overuse headaches. It collects information to better understand these conditions and who they affect.
Anqing, AnhuiAges 12 years+ - NCT06735833Recruiting
Testing embolization for chronic migraines
This study tests a procedure called MMA embolization (blocking a small artery in the head) to see if it can reduce migraine attacks in people with chronic, hard-to-treat migraines.
Phoenix, ArizonaAges 18–65 - NCT05769348Recruiting
PET brain study to test opioid signaling in migraine
This study uses brain scans (PET) to look at how the body’s “opioid” pain system works in people with migraine. It may help researchers understand migraine biology and test approaches that could improve migraine treatment.
Ann Arbor, MichiganAges 18–65 - NCT05700318Recruiting
Test of a device therapy for frequent migraine
This trial studies a migraine device (the ShiraTronics Migraine Therapy System) to help people with frequent migraine headaches. It may be a good option if you’ve tried common migraine preventions but they didn’t work for you, weren’t safe, or you couldn’t take them.
Broadmeadow, New South WalesAges 22 years+ - NCT07061847RecruitingPhase 2
Lidocaine infusion for severe chronic migraines
This trial tests if a lidocaine infusion into an artery in the head can reduce severe chronic daily headaches. It is for people who have tried multiple treatments without enough relief.
Great Neck, New YorkAges 18–75 - NCT03231241Recruiting
Study of worsening headaches using scans and blood testing
This study looks at why headaches can become long-lasting (“chronified”) by combining answers from online questionnaires, brain imaging, and blood protein tests. Your participation may help researchers find biological clues that could improve how headache problems are understood and treated.
Stanford, CaliforniaAges 18 years+ - NCT06652724Recruiting
Psychological help for chronic pain in fibromyalgia and migraine
This study looks at how psychological factors and treatments might help with chronic pain in people with fibromyalgia and/or chronic migraine. It compares different groups to understand what works best.
Rome, RMAges 18–50 - NCT06450444Recruiting
Neuromodulation implant for chronic or frequent migraine
This trial tests a new implantable device that uses mild electrical pulses to prevent migraines. It is for people who have tried at least three migraine prevention medicines without success and still have frequent migraines.
Broadmeadow, New South WalesAges 18–84 - NCT05164172RecruitingPhase 3
Eptinezumab for kids with ongoing or recurring migraine
This trial studies eptinezumab, a migraine treatment, in children and teens ages 6 to 17 who already completed an earlier migraine study. It mainly helps doctors learn whether the treatment can be continued safely and effectively over time.
New Haven, ConnecticutAges 6–17 - NCT06921109Recruiting
Virtual reality for headache relief in kids
This study tests if using virtual reality to learn relaxation techniques can help reduce headaches in children and teens who have migraines or frequent tension headaches.
Sart Tilman, LiegeAges 8–15 - NCT06810505RecruitingPhase 3
Oral atogepant for preventing migraines in teens
This trial tests an oral medication called atogepant to see if it can prevent migraines in teens aged 12–17. It aims to reduce how often migraines happen and track any side effects.
Huntsville, AlabamaAges 12–17
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Common questions
- Are there clinical trials for chronic migraine?
- Yes. Clin2 currently lists 58 recruiting chronic migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.