Clinical trials
Chronic Post Operative Pain clinical trials
Below are recruiting chronic post operative pain clinical trials, each written for real people, not researchers. We’re tracking 86 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07738770Recruiting
Comparing two numbing techniques for pain relief after mastectomy
This trial tests two different numbing injections to see which one works better for pain after breast cancer surgery. If you are having a mastectomy, you may be able to join and help find a better way to manage pain.
Jakarta, DKI JakartaAges 18–60 - NCT07680998Recruiting
Pain monitor device for recovery after day surgery
This trial tests a device that monitors pain and recovery after outpatient surgery. It may help manage pain more safely and improve your comfort after you go home.
Nîmes, GardAges 18 years+ - NCT06661642Recruiting
Predicting pain after planned surgery
This study looks at whether we can predict how much pain you will feel after surgery. It aims to help doctors better manage pain after your operation.
AalborgAges 18 years+ - NCT07541040Recruiting
Nerve Blocks for Breast Surgery Pain Relief
This trial tests two different nerve-block techniques to reduce pain after breast surgery. The study compares a serratus block with an ESP block—both are injections of numbing medication near nerves—to see which works better for managing pain without heavy opioid use.
İzmit, KocaeliAges 18–65 - NCT07386353RecruitingPhase 4
Comparing two ways to give pain medicine after C-section
This trial tests two different ways of giving morphine for pain relief after a planned cesarean section: one is injected into the spinal fluid and the other into the space around the spinal cord. The goal is to see which method works better and is safer.
Funchal, MadeiraAges 18 years+ - NCT07349810RecruitingPhase 4
Post-surgery pain pump study
This trial tests a pain pump after specific shoulder or knee surgeries to see how well it controls pain. It may help you recover more comfortably after surgery.
Somerset, New JerseyAges 18 years+ - NCT07101250RecruitingPhase 4
Study of acetazolamide before laparoscopic hysterectomy
This trial tests a medication called acetazolamide given before surgery to see if it can help prevent shoulder pain after a laparoscopic hysterectomy. If you are a woman scheduled for this type of hysterectomy, you may be able to join.
Greenville, South CarolinaAges 21–65 - NCT06978179Recruiting
Nerve blocks for pain after lower belly surgery
This trial compares two types of nerve blocks (QL block vs TAP block) to see which one provides better pain relief after lower abdominal surgery. If you are having this surgery, you may be able to join and receive one of these blocks to help manage your pain.
SohagAges 18–65 - NCT05382962Recruiting
Using an app to help teens cope with post-surgery pain
This trial tests whether a phone app (iCanCope) can help teens better manage pain after surgery for scoliosis or certain chest conditions (pectus carinatum/excavatum). If you’re having one of these surgeries soon, the app may help with coping and day-to-day comfort after the operation.
Boston, MassachusettsAges 12–18 - NCT06800209RecruitingPhase 2
Pain Reprocessing Therapy for ongoing knee pain after replacement
This study tests if Pain Reprocessing Therapy can help reduce knee pain that continues 3 months after a knee replacement. It uses a telehealth approach so you can participate from home.
Aurora, ColoradoAges 18 years+ - NCT06504277Recruiting
Lower gas pressure during surgery for shoulder pain reduction
This study compares two different gas pressures used during laparoscopic surgery to see if lower pressure reduces shoulder pain afterward. It may help if you're having surgery to remove an ovary, fallopian tube, or ovarian cyst.
Toronto, OntarioAges 18 years+ - NCT06555107Recruiting
Pain before emergency surgery and long-term pain after
This study looks at whether pain you feel before emergency surgery affects long-term pain after the surgery. It may help doctors find ways to prevent chronic pain in patients who have emergency orthopedic (bone/joint) or abdominal (belly) surgery.
AmiensAges 18 years+ - NCT06466941Recruiting
Understanding acute pain after surgery
This study surveys surgical patients about their pain and emotional experience to better understand acute pain. You may help by answering questions or sharing your story.
Boston, MassachusettsAges 18 years+ - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT06350981Enrolling by invitationPhase 2/Phase 3
Pain control after lower back fusion surgery
This study is comparing different ways to manage pain after a specific type of lower back fusion surgery called TLIF. The goal is to find the best pain control plan to make recovery more comfortable.
Tampa, FloridaAges 18 years+ - NCT06123715RecruitingPhase 2
Vitamin C to reduce pain after knee replacement
This study tests whether taking vitamin C before and after knee replacement surgery can reduce long-term pain. You may be eligible if you are having knee replacement for osteoarthritis and are generally healthy.
Toronto, OntarioAges 18 years+ - NCT05953766RecruitingPhase 2
Nerve block versus sham block after hysterectomy
This trial compares a targeted pain-relief injection near the lower back (a “nerve block”) to a sham (placebo-like) procedure during recovery from a total laparoscopic hysterectomy. It aims to see whether the real block reduces post-operative pain.
Toronto, OntarioAges 18 years+ - NCT05146778Recruiting
Opioid-free anesthesia to reduce long-term post-mastectomy pain
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
SeoulAges 19–80 - NCT05920382Recruiting
Radiofrequency treatment for long-term knee pain after knee surgery
This trial studies whether a radiofrequency procedure can reduce chronic knee pain after knee replacement surgery. It may help people who still have bothersome pain between 6 months and 5 years after their operation, as long as their pain pattern and medications are stable.
Barcelona, CataloniaAges 18 years+ - NCT05876390Enrolling by invitation
Regional anesthesia to reduce long-term breast surgery pain
This trial studies whether a pain-control technique called regional anesthesia during certain breast surgeries can lower chronic (long-lasting) pain after surgery. It may help improve comfort and quality of life for people at risk of ongoing pain after their breast operation.
Milan, LombardyAges 18 years+ - NCT05816174Recruiting
Study of long-term pain after bone surgery in children
This study follows children and teens to learn how pain can last after planned orthopedic (bone) surgery in the hospital. It may help doctors better understand which kids are more likely to have long-lasting pain and how to support them.
BaselAges 8–18 - NCT05131178Recruiting
Study for pain control after C-section
This trial looks at how to reduce pain after a C-section (cesarean delivery). You may be able to join if you’re having a scheduled or urgent C-section and can use the planned pain-control method.
Aurora, ColoradoAges 18–50 - NCT04371445RecruitingPhase 4
Dextenza drops after eye surgery to reduce post-op pain
This trial studies whether Dextenza (a steroid pain-relief eye insert) can improve comfort after a specific type of retina surgery (pars plana vitrectomy). It looks at people getting surgery for conditions like macular hole, epiretinal membrane, or vitreomacular traction.
Cleveland, OhioAges 18 years+ - NCT07548385RecruitingPhase 3
New pain medicine for after knee replacement surgery
This study tests a new medication called suzetrigine to help manage pain after knee replacement surgery. The goal is to see if it reduces pain and discomfort better than current treatments.
New York, New YorkAges 18–85
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Common questions
- Are there clinical trials for chronic post operative pain?
- Yes. Clin2 currently lists 86 recruiting chronic post operative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic post operative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic post operative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.