Clinical trials
Post Operative Pain clinical trials
Below are recruiting post operative pain clinical trials, each written for real people, not researchers. We’re tracking 185 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07855549Enrolling by invitation
Nerve blocks for pain relief after chest surgery
This study compares two types of nerve blocks (numbing injections) to see which one works better for pain relief after chest surgery. The goal is to help you feel more comfortable and use less pain medicine after your operation.
Minya, Minya GovernorateAges 18–70 - NCT07803601Recruiting
Magnesium through the vein to reduce inflammation after colon cancer surgery
This study tests whether giving magnesium through an IV during colon cancer surgery can lower the body's inflammation afterward, which may help you recover more smoothly. It is for people having open surgery for colon cancer.
Cairo, AbbassiaAges 35–75 - NCT07764666Enrolling by invitation
Cooling rinse for molar pain after root canal treatment
This study tests whether using a chilled saline rinse during a root canal treatment can reduce pain after the procedure. It compares two standard rinses, with and without cooling, to see which is more comfortable.
Cairo, Cairo GovernorateAges 15–40 - NCT06613178RecruitingPhase 4
IV acetaminophen for heart surgery recovery
This trial tests if giving acetaminophen (Tylenol) through a vein after heart surgery can help patients recover better. You may be a good fit if you are having planned heart surgery that is not an emergency.
Vancouver, British ColumbiaAges 18 years+ - NCT07738770Recruiting
Comparing two numbing techniques for pain relief after mastectomy
This trial tests two different numbing injections to see which one works better for pain after breast cancer surgery. If you are having a mastectomy, you may be able to join and help find a better way to manage pain.
Jakarta, DKI JakartaAges 18–60 - NCT07680998Recruiting
Pain monitor device for recovery after day surgery
This trial tests a device that monitors pain and recovery after outpatient surgery. It may help manage pain more safely and improve your comfort after you go home.
Nîmes, GardAges 18 years+ - NCT06661642Recruiting
Predicting pain after planned surgery
This study looks at whether we can predict how much pain you will feel after surgery. It aims to help doctors better manage pain after your operation.
AalborgAges 18 years+ - NCT07655349Recruiting
Comparing two ways to attach gum grafts after surgery
This study tests if using small titanium tacks to hold a gum graft in place causes less pain than the usual stitches. It might help people who need more attached gum around their teeth.
Cairo, Cairo GovernorateAges 18 years+ - NCT07571252RecruitingPhase 4
Pain Relief Before Jaw Surgery: A Study
This study tests whether taking pain medicine before jaw surgery (orthognathic surgery) helps reduce pain after the procedure. If you're having jaw surgery, this trial may help doctors understand the best way to manage your pain.
San JuanAges 21–65 - NCT07541040Recruiting
Nerve Blocks for Breast Surgery Pain Relief
This trial tests two different nerve-block techniques to reduce pain after breast surgery. The study compares a serratus block with an ESP block—both are injections of numbing medication near nerves—to see which works better for managing pain without heavy opioid use.
İzmit, KocaeliAges 18–65 - NCT06719180RecruitingPhase 4
Pain relief after a hysterectomy
This study tests if numbing the top of the vagina (vaginal cuff) with a local anesthetic can reduce the need for pain medicine after a hysterectomy done by laparoscopy (small cuts in the belly). If you are having this surgery for a non-cancerous condition or cancer, you may be able to join.
Flushing, New YorkAges 18 years+ - NCT06507345Recruiting
Non-opioid pain relief after breast surgery
This trial tests whether non-opioid pain medicines can effectively control pain after mastectomy or lumpectomy, allowing you to go home the same day without needing strong opioids.
Montreal, QuebecAges 18 years+ - NCT07482709RecruitingPhase 1/Phase 2
Nerve block with or without ketamine for hysterectomy pain
This study compares two ways to reduce pain after a hysterectomy: a standard nerve block with bupivacaine (a numbing medicine) versus the same block plus ketamine (a medicine that can boost pain relief). The goal is to see if adding ketamine provides better comfort after surgery.
Karachi, SindhAges 25–65 - NCT07386353RecruitingPhase 4
Comparing two ways to give pain medicine after C-section
This trial tests two different ways of giving morphine for pain relief after a planned cesarean section: one is injected into the spinal fluid and the other into the space around the spinal cord. The goal is to see which method works better and is safer.
Funchal, MadeiraAges 18 years+ - NCT07380139Enrolling by invitationPhase 1
Comparing two medications for nose surgery pain relief
This trial tests if two different medicines, dexamethasone and dexmedetomidine, given as a nerve block in your nose during rhinoplasty can better control pain after surgery.
CairoAges 18–65 - NCT07357233Recruiting
Comparing two methods for root canal pain relief in lower molars
This trial compares two different ways of cleaning and shaping the inside of a tooth (root canal) to see which one causes less pain afterward. It is for people with a specific type of tooth infection in a lower back molar.
AlexandriaAges 18–50 - NCT07349810RecruitingPhase 4
Post-surgery pain pump study
This trial tests a pain pump after specific shoulder or knee surgeries to see how well it controls pain. It may help you recover more comfortably after surgery.
Somerset, New JerseyAges 18 years+ - NCT07310953Recruiting
Using new pain scales to guide rescue pain medicine after surgery
This trial tests if a simple pain scale (the NVS and PFAS) can help doctors better decide when to give extra pain medicine after surgery. It may help control pain more quickly and effectively after a procedure called VATS.
VigoAges 18 years+ - NCT06777875Recruiting
How genes affect pain after surgery in children
This trial looks at how certain genes may affect how children feel pain after surgery. The goal is to understand if differences in your DNA can help doctors manage pain better for each child.
BeirutAges 8–18 - NCT07275710Recruiting
Alprazolam for tooth pain after root canal
This trial tests if adding alprazolam (a mild anti-anxiety medicine) to standard painkillers can better manage pain after a root canal. It aims to find a more effective way to control post-procedure discomfort.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT06843174RecruitingPhase 4
Methadone for pain during and after spine surgery
This trial tests if giving a single dose of methadone right before and during spine surgery can help manage pain better. If it works, you might need fewer other pain medicines after surgery.
Toronto, OntarioAges 18–65 - NCT07253025Recruiting
Comparing Two Root Canal Fillings for Pain Relief
This study compares two types of root canal filling materials—a resin-based sealer and a bioceramic sealer—to see which one causes less pain after the procedure. If you have a tooth with a painful, infected nerve (irreversible pulpitis), this trial may help determine which filler offers better comfort.
Peshawar, Khyber Pakhtoon Khawa(KPK)aAges 17–70 - NCT07250399Recruiting
Pain after root canal treatment with different tools
This trial compares two different ways of cleaning a tooth's root canal to see which causes less pain during and after treatment. It is for people with severe tooth pain in an upper premolar.
CairoAges 20–50 - NCT07226076RecruitingPhase 3
Methadone for knee replacement pain and less opioids
This trial tests if adding methadone during knee replacement surgery can better control pain after the operation and reduce the need for opioid painkillers. It may help you recover with less discomfort and fewer side effects from strong pain medicines.
Charleston, South CarolinaAges 18–75
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Post Operative Pain trials by city
Studies with a site in or near these metro areas.
Post Operative Pain trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for post operative pain?
- Yes. Clin2 currently lists 185 recruiting post operative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a post operative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a post operative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.