Clinical trials
Chronic Rhinosinusitis clinical trials
Below are recruiting chronic rhinosinusitis clinical trials, each written for real people, not researchers. We’re tracking 62 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07259538RecruitingPhase 1
Safety study of VVN432 nasal spray
This trial tests a nasal spray called VVN432 in healthy volunteers and people with chronic sinusitis. It checks if the spray is safe and how the body processes it.
BeijingAges 18–55 - NCT07125586Recruiting
Light-based test for eosinophilic nasal polyps during surgery
This study tests a new tool that uses light (spectroscopy) to instantly detect a type of nasal polyp during surgery. The goal is to help doctors identify polyps that are driven by eosinophils, which may guide better treatment choices for you.
Qingdao, ShandongAges 18–65 - NCT06750302RecruitingPhase 1/Phase 2
Penthrox vs placebo for sinus surgery pain
This trial tests if a pain reliever called Penthrox (methoxyflurane) works better than a placebo for pain during minor sinus procedures. If you are having a simple sinus surgery or coblation procedure, you may be able to join.
Vancouver, British ColumbiaAges 19 years+ - NCT06996951RecruitingPhase 3
Sinus treatments in cystic fibrosis with modern modulator therapy
This study looks at how different sinus treatments affect people with cystic fibrosis who are taking modern modulator therapy. It aims to understand which rinses work best for chronic sinus problems.
Indianapolis, IndianaAges 18 years+ - NCT06970977Recruiting
Chronic sinusitis questionnaire validation study
This study is testing a new questionnaire to better understand chronic sinusitis symptoms. It may help improve how doctors diagnose and treat the condition.
Santa Monica, CaliforniaAges 18 years+ - NCT06892704Recruiting
Dupilumab smell restoration study for CRSwNP
This study tests if the medication dupilumab can improve smell loss in people with chronic sinusitis and nasal polyps. Researchers will check if blocking in the nose and electrical signals in the brain can predict who will benefit.
Chicago, IllinoisAges 18–65 - NCT06776042Recruiting
Nasal polyps and smell loss study
This study looks at why people with nasal polyps lose their sense of smell and how it might come back. You may be able to join if you have had nasal blockage, runny nose, smell loss, or facial pain for at least 12 weeks, have polyps seen inside your nose, and are using a steroid spray regularly.
BrusselsAges 18–70 - NCT06368388Recruiting
Personalized phage therapy for hard-to-treat infections
This trial studies using phages (viruses that attack bacteria) to treat infections that have not improved with other treatments. It aims to see if this patient-specific approach works and what it costs.
LeuvenAges Any age - NCT06191640Recruiting
Study of sinus disease in young children with cystic fibrosis
This study looks at sinus problems in young children with cystic fibrosis. One group of children starts a new medicine called a highly effective modulator (like Trikafta), and the other group does not take this medicine. The goal is to see how the medicine affects sinus health over time.
Aurora, ColoradoAges 2–8 - NCT05531630Enrolling by invitation
Xylitol versus saline rinses for sinus symptoms in adults with CF
This study compares two kinds of nasal rinse packets—xylitol versus plain saline—to see which better reduces sinus symptoms. It may help adults with cystic fibrosis and long-term sinus inflammation feel better with routine, at-home nasal care.
LeuvenAges 18 years+ - NCT04469439Recruiting
Sinus surgery in adults with cystic fibrosis
This study looks at how endoscopic sinus surgery affects people with cystic fibrosis who have ongoing sinus problems even after medical treatments. It may help doctors understand whether surgery plus ongoing care improves symptoms and quality of life.
Los Angeles, CaliforniaAges 18–99 - NCT03725956Recruiting
Sleep study before and after nasal polyp surgery
This study uses a sleep test to look at breathing and sleep patterns in people with nasal polyps who need surgery because medicine didn’t help. It may help doctors understand how nasal polyps affect sleep and how surgery changes those sleep measurements.
LilleAges 18 years+ - NCT06567821RecruitingPhase 2/Phase 3
Using navigation to improve balloon sinus surgery accuracy
This trial tests whether using a navigation system during balloon sinus surgery makes the procedure more accurate for people with chronic sinusitis. It may help improve outcomes for those who have not had sinus surgery before.
Los Angeles, CaliforniaAges 18 years+ - NCT04645511Recruiting
Balloon treatment for long-term or repeat maxillary sinusitis
This study tests whether balloon sinuplasty works better or more efficiently for people with long-lasting or repeatedly returning inflammation in the maxillary sinuses (side sinuses near your cheeks). It focuses on people who did not improve with the usual nose spray (topical steroid) or who meet specific “recurrent” episode patterns.
TampereAges 18–69
Hear when a new Chronic Rhinosinusitis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for chronic rhinosinusitis?
- Yes. Clin2 currently lists 62 recruiting chronic rhinosinusitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic rhinosinusitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic rhinosinusitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.