Clinical trials
Chronic Rhinosinusitis clinical trials
Below are recruiting chronic rhinosinusitis clinical trials, each written for real people, not researchers. We’re tracking 62 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06338995RecruitingPhase 3
Lebrikizumab for nasal polyps and sinusitis
This trial tests a new injectable medicine (lebrikizumab) for people with chronic sinusitis and nasal polyps that steroid treatments haven't controlled. It aims to reduce polyp size and improve breathing, smell, and congestion.
Birmingham, AlabamaAges 12 years+ - NCT07498374Recruiting
Drug-eluting stent for eosinophilic sinusitis with nasal polyps
This trial tests a fully dissolvable stent that releases medication inside the sinuses after surgery. It is for patients with a specific type of sinusitis (eosinophilic) and nasal polyps who either need surgery or have had surgery and show early signs of inflammation returning.
Xi'an, ShaanxiAges 18–65 - NCT06914908Enrolling by invitationPhase 2
Long-term safety study of lunsekimig for nasal polyps
This study tests the long-term safety and effectiveness of a medication called lunsekimig for people with chronic sinusitis and nasal polyps. It is for those who already completed a previous study on this drug.
La Jolla, CaliforniaAges 18 years+ - NCT07134686Recruiting
Combined lung and ear-nose-throat care for asthma and sinusitis
This trial tests if seeing a lung specialist and an ear-nose-throat doctor together in one visit helps people with asthma and chronic sinusitis (with nasal polyps) feel better than seeing each specialist separately. You may qualify if your asthma or sinusitis is not well-controlled and you've used steroid pills in the past year.
MarseilleAges 18 years+ - NCT07073664Enrolling by invitation
Endoscopic sinus expansion plus Stapokibart for chronic sinusitis
This trial tests if a new drug (Stapokibart) combined with a sinus surgery improves symptoms like nasal congestion, discharge, and loss of smell in people with type 2 chronic sinusitis.
Changchun, JilinAges 18–75 - NCT02038166Recruiting
Measuring nasal function in adults with chronic sinus symptoms
This study tests a specialized way of measuring how your nasal lining responds in people with chronic rhinosinusitis (long-lasting sinus inflammation). The goal is to see whether the nasal measurement is usable and safe, and to help better understand chronic sinus disease.
Birmingham, AlabamaAges 18 years+ - NCT05427695RecruitingPhase 2
Probiotic rinse to treat chronic sinus inflammation
This Phase 2 study tests whether washing your sinuses with a probiotic solution can improve chronic sinusitis symptoms and inflammation. It’s for adults with chronic sinus symptoms that have flared, especially if you’ve had sinus surgery in the past.
Chicago, IllinoisAges 18 years+ - NCT07174115RecruitingPhase 2
Testing a new tablet for chronic sinusitis without nasal polyps
This trial tests an experimental tablet (HTMC0658) for people with chronic sinusitis that hasn't improved with standard nasal spray. You may join if your symptoms are moderate to severe and you've been using a stable dose of mometasone spray for at least 4 weeks.
Luoyang, HenanAges 18–75 - NCT06824649RecruitingPhase 4
Comparing biologics for chronic sinusitis with nasal polyps
This trial compares three different biologic medications (injectable drugs) to see which one works best for people with chronic sinusitis and nasal polyps. If you have moderate to severe symptoms and are considering biologic therapy, this study might help find the best option for you.
Gainesville, FloridaAges 18 years+ - NCT07867184Enrolling by invitation
Firefighter lung health study
This study looks at how firefighting affects your lungs over time. By tracking your health and exposures, researchers hope to find ways to prevent lung problems in firefighters.
Bethesda, MarylandAges 18–65 - NCT07107256RecruitingPhase 3
Study of TQC2731 for chronic sinusitis with nasal polyps
This trial tests an injectable drug called TQC2731 for people with chronic sinusitis and nasal polyps that haven't been controlled well enough by standard treatments like steroid sprays or surgery. The goal is to see if it helps reduce nasal congestion, improve sense of smell, and shrink polyps.
Fuyang, AnhuiAges 18–75 - NCT07520162RecruitingPhase 3
Tezepelumab for Nasal Polyps in Chinese Adults
This study tests whether tezepelumab, a new injectable medicine, can help reduce nasal polyps and improve symptoms like nasal congestion, loss of smell, and sleep problems. You would receive the study drug while continuing your current nasal steroid spray, and your doctors would track how your symptoms change.
BeijingAges 18 years+ - NCT05061329Recruiting
Learn how the nose’s microbes relate to health and disease
This study explores the tiny living organisms (microbes) in your nose and how they may be linked to health problems. It may help researchers better understand disease triggers and potential new prevention or treatment ideas.
Holstebro, Central JutlandAges 18 years+ - NCT05708300Recruiting
Testing how mepolizumab works for people with nasal polyps
This study looks at blood and other measures (biomarkers) to understand how well mepolizumab helps people with nasal polyps, with or without asthma. It aims to find response clues that could help personalize treatment in the future.
Thessaloniki, ExochiAges 18 years+ - NCT05938972Recruiting
Study of biologic medicines in severe CRSwNP patients
This study looks at how “biologic” medicines work in real-life care for people with severe chronic rhinosinusitis with nasal polyps (CRSwNP). It may help confirm which patients benefit and how treatment is used in everyday practice.
GhentAges 18–80 - NCT07782957RecruitingPhase 3
New shot for severe nasal polyps with ongoing sinus symptoms
This study tests an experimental medication called felcorekibart, given as an injection, to see if it reduces nasal polyps and improves sinus symptoms like congestion and loss of smell. It is for adults who have had nasal polyps for at least a year and have already tried standard treatments like steroid sprays or pills, or had surgery.
Sherman Oaks, CaliforniaAges 18 years+ - NCT07782970RecruitingPhase 3
Treatment for chronic sinusitis with nasal polyps
This study tests a new medication (felcorekibart) to see if it reduces nasal polyps and symptoms like congestion and loss of smell. It may help people whose current treatments aren't enough.
Los Angeles, CaliforniaAges 18 years+ - NCT07714525RecruitingPhase 2
Steroid nanocapsules after nasal surgery
This trial tests whether a new form of steroid (triamcinolone) delivered in tiny capsules can improve healing after common nasal surgeries for chronic sinusitis or nasal polyps.
Minya, Menia GovernorateAges 18–60 - NCT07701967RecruitingPhase 4
Depemokimab for chronic sinusitis with nasal polyps
This trial tests a new antibody medicine (depemokimab) for Japanese adults with chronic sinusitis and nasal polyps. It aims to see if the drug alone can reduce symptoms without needing steroid nasal sprays.
EhimeAges 18 years+ - NCT07681973Recruiting
Smell training for loss of smell in sinus patients
This study tests whether smell training can improve your sense of smell and affect your immune system. It is for people with chronic sinus inflammation and nasal polyps who have lost their sense of smell.
Cleveland, OhioAges 18 years+ - NCT07633158Recruiting
Real-world study of tezepelumab for chronic nasal polyps
This study follows patients with chronic rhinosinusitis with nasal polyps (CRSwNP)—a condition causing blocked sinuses and nasal growths—who are starting a new biologic medication called tezepelumab. Researchers will track how symptoms and quality of life improve over time in everyday medical practice.
BochumAges 18–130 - NCT07546682Recruiting
Propel Sinus Implant Study in Japan
This study tests a steroid-releasing implant placed during sinus surgery to help prevent inflammation and improve healing in patients with chronic sinus infections. If you're having sinus surgery in Japan, this trial may track how well the implant works for you.
AsahikawaAges 18 years+ - NCT07299474Recruiting
Lavender scent for anxiety and pain during awake ENT procedures
This study tests whether smelling lavender essential oil during an awake ear, nose, or throat procedure can help reduce anxiety and pain. If you qualify, you may receive the lavender scent during your procedure and report how you feel.
Los Angeles, CaliforniaAges 18 years+ - NCT07262450Recruiting
Seawater spray for stuffy nose and sinus symptoms
This trial tests whether a seawater nasal spray can relieve nasal congestion, runny nose, and other sinus symptoms in people with colds, allergies, or after nose surgery. You will use the spray as directed and answer online questionnaires for up to 3 months.
BordeauxAges 2 weeks+
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Common questions
- Are there clinical trials for chronic rhinosinusitis?
- Yes. Clin2 currently lists 62 recruiting chronic rhinosinusitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic rhinosinusitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic rhinosinusitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.