Clinical trials
Rhinosinusitis clinical trials
Below are recruiting rhinosinusitis clinical trials, each written for real people, not researchers. We’re tracking 65 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05935683Recruiting
Registry for severe, uncontrolled chronic sinusitis in Italy
This trial is a registry that enrolls people with severe, hard-to-control chronic sinusitis. It helps doctors better understand this specific type of inflammation and how it affects symptoms and quality of life.
Rozzano, MIlanAges 18 years+ - NCT06683261Recruiting
Real-world study of biologics for nasal polyps
This study follows people with chronic rhinosinusitis and nasal polyps who are starting a biologic medication (omalizumab, mepolizumab, or dupilumab) to see how well it works in real life.
AalstAges 18 years+ - NCT07184684RecruitingPhase 2/Phase 3
Nasal bacteria transplant for chronic sinusitis
This trial tests if transplanting healthy nasal bacteria from a donor can help people with chronic sinusitis. It aims to restore a healthy microbiome in the nose to reduce symptoms like congestion and discharge.
HelsingborgAges 18 years+ - NCT06901297RecruitingPhase 3
Raphamin for acute sinus infection in adults
This trial tests a new medicine called Raphamin for treating sudden sinus infection (acute rhinosinusitis) in adults. It compares the medicine to a placebo to see if it can reduce symptoms like facial pain and pressure when started within the first 2 days of illness.
AramilAges 18–75 - NCT07383493Recruiting
Treatments for cold and sinus infections
This study tests treatments for the common cold, sinus pain, or sore throat caused by a virus. It compares different options to see which works best for reducing symptoms like runny nose, congestion, and cough.
Clermont-FerrandAges 18–70 - NCT07399665Recruiting
Tezepelumab for chronic sinusitis with nasal polyps in Russia
This study tracks how well tezepelumab works for people with chronic sinusitis and nasal polyps in real-world settings. It aims to see if this medication reduces symptoms and the need for surgery.
Kazan'Ages 18 years+ - NCT06960876Recruiting
Ultrasound vs. sinus massage for chronic sinusitis
This study compares two treatments for chronic sinusitis: ultrasound therapy (sound waves applied to the face) and sinus massage (gentle pressure on the face). Both are non-drug options that may help relieve your symptoms.
IslamabadAges 20–60 - NCT05246267Recruiting
Dupilumab study for chronic sinus disease with nasal polyps
This study looks at how dupilumab (an injection medicine) helps people with chronic rhinosinusitis with nasal polyps, including how well it works across different ethnic backgrounds. You may be able to join if you’ve been diagnosed and you can get dupilumab through insurance or a patient assistance program.
The Bronx, New YorkAges 18–99 - NCT04670172Recruiting
Chronic sinusitis patient registry using a phone app
This study builds a real-world record of symptoms and outcomes in people with chronic sinusitis. You may help by using a smartphone app to report your symptoms over time.
GrazAges 18 years+ - NCT07286201Enrolling by invitation
Nasal packing with steroid to improve sinus surgery results
This study tests a special nose dressing that slowly releases a steroid to reduce inflammation and improve healing after sinus surgery for chronic sinusitis with or without nasal polyps.
Colorado Springs, ColoradoAges 18 years+ - NCT06850805RecruitingPhase 3
Nasal spray for teens with chronic sinusitis without polyps
This study tests a new nasal spray (OPN-375) for teens aged 12–17 with chronic sinusitis but without nasal polyps. It aims to see if the spray improves symptoms like congestion and runny nose.
Gilbert, ArizonaAges 12–17 - NCT06398873Recruiting
Dupilumab and nasal lining in chronic sinusitis with polyps
This study tests whether dupilumab, a medication given as an injection, helps improve the lining of the nose in people with chronic sinus inflammation and nasal polyps. If you have nasal polyps and are about to start dupilumab, or if you have sinusitis without polyps, you may be eligible to join.
Vienna, AustriaAges 18–99 - NCT07132827RecruitingPhase 3
Study of SHR-1905 for chronic sinusitis with nasal polyps
This trial tests a new injection (SHR-1905) for people with chronic sinusitis and nasal polyps who still have symptoms despite using standard nasal spray treatments. It aims to see if the drug can reduce polyp size and improve symptoms.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07010679Enrolling by invitation
How patients decide about sinus surgery
This study looks at how people with long-term sinus problems decide whether to have sinus surgery. Researchers want to understand what matters most to patients when choosing treatment.
Arcadia, CaliforniaAges 18 years+ - NCT07498374Recruiting
Drug-eluting stent for eosinophilic sinusitis with nasal polyps
This trial tests a fully dissolvable stent that releases medication inside the sinuses after surgery. It is for patients with a specific type of sinusitis (eosinophilic) and nasal polyps who either need surgery or have had surgery and show early signs of inflammation returning.
Xi'an, ShaanxiAges 18–65 - NCT05882903RecruitingPhase 2
Nasal steroid cream after sinus surgery for chronic sinus trouble
This trial studies whether placing a steroid nasal cream inside your sinus area can reduce symptoms in people with chronic rhinosinusitis (CRS) even after sinus surgery. It may help lower ongoing inflammation and symptoms for those who still feel unwell despite usual medical treatments.
Sydney, New South WalesAges 18–80 - NCT06338995RecruitingPhase 3
Lebrikizumab for nasal polyps and sinusitis
This trial tests a new injectable medicine (lebrikizumab) for people with chronic sinusitis and nasal polyps that steroid treatments haven't controlled. It aims to reduce polyp size and improve breathing, smell, and congestion.
Birmingham, AlabamaAges 12 years+ - NCT07290140Recruiting
Balloon treatment for chronic sinusitis
This trial tests a balloon coated with a medicine (paclitaxel) to treat chronic sinusitis. It may help reduce inflammation and improve sinus drainage in adults with long-lasting sinus problems.
Birmingham, AlabamaAges 18 years+ - NCT07436949RecruitingPhase 1/Phase 2
Study of BBT002 for chronic sinusitis with nasal polyps and asthma
This study tests a new drug called BBT002 in healthy people and in patients with chronic sinusitis and nasal polyps, with or without asthma. It aims to see if the drug is safe and effective for reducing symptoms.
Beijing, Beijing MunicipalityAges 18–75 - NCT06914908Enrolling by invitationPhase 2
Long-term safety study of lunsekimig for nasal polyps
This study tests the long-term safety and effectiveness of a medication called lunsekimig for people with chronic sinusitis and nasal polyps. It is for those who already completed a previous study on this drug.
La Jolla, CaliforniaAges 18 years+ - NCT03439865RecruitingEarly Phase 1
Ivacaftor for sinus problems linked to faulty CFTR
This early-phase study tests whether ivacaftor can improve chronic sinus disease caused by problems with a specific body channel called CFTR. It may help some people whose sinus imaging, cultures, and prior sinus surgery match the study’s criteria.
Birmingham, AlabamaAges 18 years+ - NCT06616792Enrolling by invitation
Sound wave steroid vs. laser acupuncture for chronic sinusitis
This study tests two treatments for chronic sinusitis: one uses sound waves to deliver a steroid (dexamethasone) through the skin, and the other uses laser acupuncture. It aims to see which works better for reducing symptoms like congestion, facial pain, and reduced sense of smell.
Dokki, Giza GovernorateAges 30–50 - NCT06986629Recruiting
Light or magnetic field therapy for chronic sinusitis
This trial tests two treatments—light therapy or pulsed magnetic fields—to see if they improve quality of life for adults with chronic sinusitis. It may help if your symptoms are mild to moderate and you have allergies.
CairoAges 20–40 - NCT07187583RecruitingPhase 4
Reducing biologic doses for chronic sinusitis with polyps
This trial tests if patients with chronic sinusitis and nasal polyps can safely reduce how often they take their biologic medication (dupilumab or mepolizumab) after their disease has been partly controlled for at least a year.
AalborgAges 18 years+
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Common questions
- Are there clinical trials for rhinosinusitis?
- Yes. Clin2 currently lists 65 recruiting rhinosinusitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rhinosinusitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rhinosinusitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Chronic Rhinosinusitis With Nasal Polyps
- Chronic Rhinosinusitis (CRS)
- Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
- Chronic Rhinosinusitis (Diagnosis)
- Chronic Rhinosinusitis
- Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
- Chronic Rhinosinusitis Without Nasal Polyps
- Non Small Cell Lung Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.