Clinical trials
Cigarette Smoking Behavior clinical trials
Below are recruiting cigarette smoking behavior clinical trials, each written for real people, not researchers. We’re tracking 47 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06118502Recruiting
Adaptive quit-smoking treatment for early relapse
This trial tests a flexible treatment approach for smokers who want to quit and are at risk of relapsing early. It aims to help you stay smoke-free by adjusting the support you get.
Charleston, South CarolinaAges 21 years+ - NCT06072547Recruiting
Can flavored nicotine pouches help you smoke less?
This study tests if flavored nicotine pouches can help adults who smoke at least 5 cigarettes a day switch away from smoking. You'll use the pouches instead of cigarettes, and researchers will track your smoking habits.
Raleigh, North CarolinaAges 22–65 - NCT06787937Recruiting
Study on reducing nicotine in cigarettes
This study tests cigarettes that have less nicotine to see how people react to them. You may be able to join if you are a regular adult smoker interested in trying reduced-nicotine cigarettes.
Atlanta, GeorgiaAges 21 years+ - NCT06373679Recruiting
Switch or Quit: A study for smokers who want to quit
This study helps adults 21 and older who have tried to quit smoking with a stop-smoking medication. You may be able to join if you want to try quitting again or want to reduce harm from tobacco.
Charleston, South CarolinaAges 21 years+ - NCT07199517Recruiting
Helping smokers who aren't ready to quit
This study tests whether switching to a less harmful nicotine product (like a nicotine pouch or e-cigarette) can help people who are not ready to quit smoking reduce their health risks. You would be given a sample of a harm reduction product to try, and researchers will check how it affects your smoking habits.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06260683Recruiting
Comparing tobacco vs. non-tobacco flavored e-cigarettes for quitting smoking
This study tests whether using e-cigarettes with a tobacco flavor or a non-tobacco flavor helps people who smoke switch away from regular cigarettes. Participants will use either e-cigarettes or nicotine replacement therapy for a period of time, and researchers will track their smoking behavior.
Columbus, OhioAges 21 years+ - NCT06945120Recruiting
Lung Health Program for Chinese and Korean Smokers
This study is testing a program to help Chinese and Korean adults who smoke to improve their lung health. You may be able to join if you are a current smoker, speak Korean, Mandarin, or English, and live in the U.S.
Boston, MassachusettsAges 18–100 - NCT06693700Recruiting
Using an air quality monitor to help make your home smoke-free
This study tests whether an indoor air quality monitor can help people keep their homes smoke-free. It is for MSK patients who currently smoke and want to reduce smoke exposure indoors.
Basking Ridge, New JerseyAges 18 years+ - NCT06077240Recruiting
E-cigarettes vs pouches for quitting smoking
This study compares the effects of e-cigarettes and nicotine pouches on smoking habits and addiction. The goal is to see which method helps people smoke less and reduces their dependence on cigarettes.
New Haven, ConnecticutAges 21 years+ - NCT07119489Recruiting
Group therapy to help cancer patients quit smoking
This trial tests a new type of group therapy (based on dialectical behavior therapy) to help cancer patients quit smoking. It is designed for patients who currently smoke and want to learn coping skills to stop.
Charlotte, North CarolinaAges 18 years+ - NCT06228235Recruiting
Brain stimulation to reduce smoking cravings
This study tests whether a non-invasive brain stimulation technique (rTMS) combined with a behavioral task can reduce your craving to smoke. It might help if you smoke regularly and want to cut back.
Morgantown, West VirginiaAges 18–60 - NCT06609083RecruitingPhase 1
How cannabis affects cigarette smoking
This study looks at how cannabis affects cigarette smoking habits. If you smoke every day and also use cannabis weekly, researchers want to see if cannabis changes how much you smoke.
Baltimore, MarylandAges 21 years+ - NCT06264154Recruiting
Can e-cigarette flavor help you quit smoking?
This study looks at whether the flavor of an e-cigarette can help people who keep smoking switch completely away from regular cigarettes. Participants will use e-cigarettes with different flavors for 6 weeks.
Philadelphia, PennsylvaniaAges 21 years+ - NCT05572671Recruiting
Study brain scans to predict near-term smoking relapse risk
This study uses MRI brain scans and smoking measurements to understand what may predict when someone is about to smoke again. If you qualify, you’ll be asked to avoid nicotine for 12 hours before a lab visit and complete MRI safety screening.
University Park, PennsylvaniaAges 21–65 - NCT03514602Recruiting
Help quitting smoking to prevent childhood obesity
This study supports pregnant people who smoke to quit or cut down, using behavior-based coaching. It also measures how changes in smoking may help lower a child’s risk of developing obesity.
Buffalo, New YorkAges 18–39 - NCT07348679Recruiting
Cigarette filter study for adult smokers
This study tests how different cigarette filters work in smokers who are not trying to quit. You must smoke at least 5 non-menthol cigarettes daily and not use Natural American Spirit or menthol brands.
New Brunswick, New JerseyAges 21 years+ - NCT07132814Recruiting
Testing abuse potential of five oral nicotine products
This study tests how much people might want to use five different types of modern oral nicotine products (like pouches or lozenges) compared to smoking their usual cigarette. It helps researchers understand if these products could be less addictive than cigarettes.
Overland Park, KansasAges 21–60 - NCT06470321Recruiting
Predictors of nicotine relapse in smokers
This study looks at factors that might predict whether someone will start smoking again after quitting. It is for adults who smoke daily, want to quit, and are not on any medications.
NicosiaAges 18–60 - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+ - NCT07602699RecruitingPhase 2
Tirzepatide to Help People Quit Smoking
This study tests whether tirzepatide, a medication that helps with weight and blood sugar, can also help people quit smoking. You'd receive the medication plus standard quitting support (nicotine patches or gum and a quit-smoking app) over several months.
Los Angeles, CaliforniaAges 21–65 - NCT07129590Recruiting
Trauma-informed care to help pregnant people quit smoking
This study tests whether a trauma-informed care approach can help pregnant people who have experienced trauma to quit smoking. The study involves clinicians and patients working together to improve smoking cessation support.
San Francisco, CaliforniaAges 18 years+ - NCT06145763Recruiting
Quit smoking with a digital program for American Indian and Alaska Native adults
This study tests two smartphone apps to help American Indian and Alaska Native adults quit smoking. You will be randomly assigned to one of the apps and complete short surveys to see which works better.
Seattle, WashingtonAges 18 years+ - NCT07459621Recruiting
App for smokers unsure about quitting
This study tests a smartphone app for people who smoke at least half a pack a day and are not sure they want to quit. The app helps them explore their feelings about smoking in a low-pressure way.
Portland, OregonAges 18 years+ - NCT06873009Enrolling by invitation
Can therapy help men in prison quit smoking?
This trial tests if cognitive behavioural therapy (a type of talk therapy that changes thinking and habits) can help men in prison stop smoking. It aims to see what works best and for whom.
Paris, Île-de-France RegionAges 18 years+
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Common questions
- Are there clinical trials for cigarette smoking behavior?
- Yes. Clin2 currently lists 47 recruiting cigarette smoking behavior studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cigarette smoking behavior trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cigarette smoking behavior trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.