Clinical trials
Cognition clinical trials
Below are recruiting cognition clinical trials, each written for real people, not researchers. We’re tracking 2,028 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05598034Recruiting
Brain stimulation with tDCS for moderate depression
This study tests whether a noninvasive brain stimulation called tDCS can improve depression symptoms. It also uses MRI scans, aiming to understand how brain changes may relate to symptom improvement.
Los Angeles, CaliforniaAges 20–55 - NCT05600946Recruiting
Study of body differences in creatine transporter deficiency
This study looks at physical and body features in people with creatine transporter deficiency caused by a specific gene change (SLC6A8). It may help doctors better understand the condition and how it shows up, which can improve future care.
Bethesda, MarylandAges 2–40 - NCT05606341RecruitingPhase 1
Testing a diabetes-style shot to boost brain immunity in early Alzheimer’s
This Phase 1 study tests whether stimulating the immune system (through a receptor called TLR9) is safe and may affect brain changes in people with early Alzheimer’s. It mainly enrolls older adults with memory impairment confirmed by specific amyloid imaging.
New York, New YorkAges 60–85 - NCT05608434RecruitingPhase 1/Phase 2
VR training for improving attention in kids with ADHD
This study tests a virtual reality (VR) program meant to strengthen attention skills in children with ADHD. It compares different VR-based training options and looks at whether kids improve on attention-related thinking skills after the sessions.
Bethesda, MarylandAges 8–16 - NCT05612750Recruiting
Online therapy for chronic pain: CBT vs one-session relief
This study compares two online treatments for chronic pain: an 8-session cognitive behavioral therapy (CBT) program versus a single “empowered relief” session. It aims to see which approach helps people manage pain better over time.
Phoenix, ArizonaAges 18 years+ - NCT05614310Recruiting
Brain scan study to spot early Alzheimer’s
This study uses MRI brain scans and memory tests to help detect early Alzheimer’s disease. It compares people with Alzheimer’s (diagnosed by a clinician) with people without memory problems to see which scan and test results stand out.
AberdeenAges 18 years+ - NCT05619068Recruiting
Study tracking outcomes in Moyamoya disease
This study looks at how Moyamoya disease changes over time and what predicts outcomes. It uses approved brain imaging and, likely, thinking/memory tests to understand prognosis.
Beijing, Beijing MunicipalityAges 10–60 - NCT05625425Recruiting
Study testing a memory and wayfinding training program
This study tests a wayfinding (getting around) training program and how it may affect long-term memory. You may need brain scans (fMRI), virtual reality tasks, and regular short walks to participate.
San Francisco, CaliforniaAges 60–85 - NCT05629871Recruiting
Tracking sleep changes in early Alzheimer’s and thinking decline
This study looks at how sleep and wake patterns change in people with early Alzheimer’s, and whether these changes relate to memory and thinking decline. You may be asked to do questionnaires, sleep diaries, and possibly a diagnostic spinal fluid test (lumbar puncture) to measure biomarkers.
MontpellierAges 50–85 - NCT05649514Recruiting
Studying sleep problems in early Alzheimer’s risk patients
This study looks at sleep problems in people with mild Alzheimer’s disease and whether sleep measurements and questionnaires can help researchers understand early changes. You may be able to join if your diagnosis is mild and you can complete repeated sleep and thinking questionnaires with a family caregiver’s help.
Montpellier, HéraultAges 50–85 - NCT05649800Recruiting
Study brain and blood-vessel changes in older adults after stroke
This study looks at how blood flow in the brain and related brain processes change after stroke, especially when someone also has conditions like dementia, depression, or delirium. It may help researchers understand what drives these problems and how they connect.
Leicester, LeicestershireAges 65 years+ - NCT05658731Recruiting
Radiation planning study to protect thinking in children
This study compares how radiation is planned to see whether it better protects thinking and memory in children and young adults. It may help future patients by learning which planning approach leads to better cognitive (thinking) outcomes.
Washington D.C., District of ColumbiaAges 1–26 - NCT05661084Recruiting
Non-surgery brain stimulation for dementia thinking and movement
This study tests whether a non-invasive brain stimulation device (tES) can improve thinking and movement problems in people with dementia. You (and your caregiver, if needed) will be asked to follow the study plan and attend visits so researchers can measure results and safety.
Boston, MassachusettsAges 55 years+ - NCT05674409Recruiting
Telehealth family program for moderate to severe alcohol use
This study tests a brief treatment delivered by video that involves a Veteran and a concerned family member or friend. It’s meant for Veterans with ongoing alcohol problems, to see if family involvement helps them change drinking and stay safe during treatment.
Charleston, South CarolinaAges 21 years+ - NCT05676918Recruiting
Postpartum well-being study for mothers in the past year
This study looks at mothers’ well-being after having a baby, to understand what affects mental and emotional health after childbirth. It may help improve support for mothers during the postnatal period.
Madrid, Pozuelo de AlarcónAges 18 years+ - NCT05683145Recruiting
Better sleep for people with moderate or severe TBI
This trial studies an approach to improve insomnia (trouble falling or staying asleep) in people who had a moderate-to-severe traumatic brain injury at least one year ago. If you qualify, it may help you restore more regular, efficient sleep after TBI.
Aurora, ColoradoAges 18–60 - NCT05699525Recruiting
Personalized app for cognitive behavioral therapy for young adults
This trial tests a mobile app that delivers personalized cognitive behavioral therapy (a structured talk-therapy approach that helps change unhelpful thoughts and behaviors). It may help reduce symptoms of anxiety, depression, or bipolar disorder for people who fit the study’s timing and safety requirements.
New York, New YorkAges 18–25 - NCT05700279Recruiting
PTSD treatment to help prevent future chronic pain
This study tests whether treating post-traumatic stress disorder (PTSD) right when you come to the emergency room for new, acute pain can lower the chance you develop long-term (chronic) pain. It may help people whose pain and trauma symptoms start around the same time.
Chicago, IllinoisAges 18–70 - NCT05708807Recruiting
Follow-up study of recovery after first-time stroke in Gothenburg
This study tracks how people recover after their first-ever stroke (either blocked artery stroke or bleeding in the brain). It may help doctors better understand recovery patterns and what support could work best over time.
GothenburgAges 18 years+ - NCT05710549Recruiting
Brain study of autobiographical memory using brain stimulation
This study looks at how the brain supports remembering your own past experiences. It tests brain mechanisms using brain scanning (MRI) and noninvasive brain stimulation to see how these memory processes work.
Geneva, Canton of GenevaAges 18–85 - NCT05712057Recruiting
Brain stimulation vs therapy for emotion regulation problems
This trial compares a type of brain stimulation (rTMS) to therapy to help people better manage strong emotions. You may be eligible if you have ongoing difficulties with emotion control and meet specific mood, anxiety, or related symptom criteria.
Durham, North CarolinaAges 18–55 - NCT05715710Recruiting
MRI and brain vein pattern study for memory and thinking problems
This study looks at whether certain deep brain veins seen on MRI are linked to thinking and memory problems in people with small-vessel brain disease. It compares brain scan findings with cognitive (thinking) testing to better understand what may drive cognitive dysfunction.
Zigong, SichuanAges 50–85 - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT05726045Recruiting
Sleep-based brain training to help you quit smoking
This study tests a way to improve smoking cessation using special sleep-based brain stimulation and memory support. If it works, it may help you stay committed to quitting by strengthening helpful brain learning during sleep.
Mannheim, Baden-WurttembergAges 18–65
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Common questions
- Are there clinical trials for cognition?
- Yes. Clin2 currently lists 2,028 recruiting cognition studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognition trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognition trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.