Clinical trials
Cold Exposure clinical trials
Below are recruiting cold exposure clinical trials, each written for real people, not researchers. We’re tracking 14 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07538479RecruitingPhase 1
Cold Exposure Plus Immunotherapy for Advanced Solid Tumors
This study tests whether controlled cold exposure combined with PD-1/PD-L1 immunotherapy (checkpoint inhibitor drugs that boost your immune system) can help fight solid tumors better than immunotherapy alone. The cold exposure is meant to trigger immune responses that may make the immunotherapy work more effectively.
Chengdu, SichuanAges 18–75 - NCT05822141Recruiting
Omega-3 effects on body fat in cold exposure
This study tests whether omega-3 (fish oil–type) changes how your body fat responds when you are exposed to cold. It may help researchers understand how to regulate “brown fat,” which can be involved in how your body uses energy during cold.
Bloomington, IndianaAges 18–40 - NCT06667193Enrolling by invitation
Cold water exposure and its effects on health
This study looks at how cold water immersion affects your physical and mental health. It compares people who haven't done cold water exposure before and may help us understand its benefits.
Greeley, ColoradoAges 18–45 - NCT07048405Recruiting
Does Cold Boost Brown Fat in Healthy People?
This study tests whether brief, repeated exposure to cold can increase your body's 'brown fat,' a type of fat that burns energy and may help with metabolism. Healthy volunteers will undergo controlled cooling sessions and imaging scans to measure changes in their brown fat activity.
EdinburghAges 18–40 - NCT07489690Recruiting
High-energy diet test for cold-weather military operations
This study tests whether a high-energy diet helps military personnel perform better in cold weather. Participants will follow special diets and do exercise tests in a cold environment.
Natick, MassachusettsAges 18–39 - NCT07573917Recruiting
Cold Shivering to Improve Insulin Sensitivity in Type 2 Diabetes
This study tests whether controlled exposure to cold—which causes your body to shiver and produce heat—can help your body use insulin better. You'll undergo repeated cold sessions over several weeks while researchers monitor your blood sugar control and metabolism.
Sherbrooke, QuebecAges 40–75 - NCT07611422Recruiting
Cold Showers and Stress Response Study
This 4-week study examines how taking cold showers might affect stress levels and how your body responds to stress. Researchers want to understand if cold exposure can help manage stress naturally.
MilanAges 18–60 - NCT03811236Recruiting
Test cold exposure to activate body fat and reduce liver fat
This study tests whether controlled cold exposure can activate “brown fat” and affect liver fat buildup. It may help people with excess liver fat, measured on imaging, but it has several health and medication exclusions.
ViennaAges 18–50 - NCT06652425Recruiting
How cold affects the heart and blood vessels
This study looks at how brief cold exposure affects the heart and blood vessels in healthy adults. It may help us understand the body's response to cold and its potential health impacts.
Shanghai, Shanghai MunicipalityAges 18–30 - NCT07327684Recruiting
Imaging brown fat activity with ultrasound
This study uses a special camera (photoacoustic/ultrasound) to look at a type of fat called 'brown fat' that helps your body burn energy. You may be able to join as a healthy volunteer or if you have a condition like type 2 diabetes or PCOS.
BeijingAges 18–80 - NCT07574970Recruiting
Preventing pancreatitis after endoscopic bile duct procedures
This study tests whether combining a rectal anti-inflammatory medication (indomethacin) with cold water cooling of the pancreas opening during an endoscopic procedure can better prevent pancreatitis—a painful inflammation of the pancreas—compared to medication alone.
Hyderabad, TelanganaAges 18–60 - NCT06729632Recruiting
Cooling device to protect ears from noise damage
This trial tests a non-invasive device that cools the ears to prevent hearing loss from loud noise. It is for adults aged 18-55 with normal hearing who are at risk for noise-induced hearing loss, such as firefighters.
Miami, FloridaAges 18–55 - NCT04423874Recruiting
Tests how unpleasant sounds change pain tolerance
This study tests whether hearing unpleasant, non-verbal sounds changes how much pain you can tolerate. It may help researchers understand how stress and sound affect pain experiences.
Saint-EtienneAges 18–60 - NCT07564739Recruiting
Cold Plasma Treatment for Long-Lasting Wound Healing
This study tests whether a special cold plasma treatment (a type of energized gas) can safely help heal chronic wounds that haven't improved after several weeks. Cold plasma may help clean wounds and reduce bacteria, potentially speeding up healing.
OrléansAges 18 years+
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Common questions
- Are there clinical trials for cold exposure?
- Yes. Clin2 currently lists 14 recruiting cold exposure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cold exposure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cold exposure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.