Clinical trials
Colon Cancer Stage III clinical trials
Below are recruiting colon cancer stage iii clinical trials, each written for real people, not researchers. We’re tracking 74 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05970133Recruiting
Robotic surgery vs laparoscopy for left colon cancer
This trial compares two ways to remove left-sided colon cancer and take the specimen out through the anus (without a large external incision). It may help find which approach is safer and more effective for curing Stage I–III disease.
TaipeiAges 18 years+ - NCT06006390RecruitingPhase 1/Phase 2
CAR-T therapy for CEA-positive advanced solid tumors
This trial tests a new treatment called CAR-T cells that are designed to find and attack cancer cells carrying a protein called CEA. It is for people with advanced colorectal, esophageal, stomach, or pancreatic cancer who have already tried other treatments.
Taiyuan, ShanxiAges 18 years+ - NCT06076811Recruiting
Guiding colorectal cancer follow-up with a blood test
This trial uses a blood test (liquid biopsy) to look for tiny bits of cancer DNA remaining after surgery. It aims to see if this test can help guide follow-up and treatment decisions for people with colorectal cancer.
Copenhagen, Capital Region of DenmarkAges 18 years+ - NCT06111105Recruiting
Comparing blood tests to guide colon cancer treatment
This study compares different blood tests to find the best way to detect tiny bits of cancer DNA after surgery for stage III colorectal cancer. It aims to help doctors decide if additional chemotherapy is needed to prevent the cancer from coming back.
Graz, StyriaAges 18 years+ - NCT06126406RecruitingPhase 1
CEA-targeting CAR-T cell therapy for advanced solid tumors
This trial tests a new immune cell therapy (CAR-T) designed to attack cancer cells that make a protein called CEA. It may be an option for people with advanced colorectal, esophageal, gastric, or pancreatic cancer who have already tried at least two standard treatments.
Wuhu, AnhuiAges 18 years+ - NCT06204484Recruiting
MRD-guided Chemo Timing for Early Colon Cancer
This trial is for people with early-stage colon cancer (stage II high-risk or stage III low-risk) that is not MSI-H. It uses a blood test (MRD) to see if you can safely delay or skip extra chemotherapy after surgery, based on whether the test finds any leftover cancer cells.
Guangzhou, GuangdongAges 18–70 - NCT06242418RecruitingPhase 2
ctDNA-Guided Chemo for Stage III Colon Cancer
This trial tests whether checking for cancer DNA in your blood (ctDNA) can help doctors decide if you need extra chemotherapy after surgery for stage III colon cancer. It aims to personalize treatment and avoid unnecessary chemo.
Guiyang, GuizhouAges 18–75 - NCT06254521RecruitingPhase 2
Tislelizumab plus chemo before surgery for MSS rectal cancer
This trial tests a combination of an immunotherapy drug (tislelizumab) plus chemotherapy before surgery for people with a specific type of rectal cancer that has not spread to other organs. The goal is to see if this approach can shrink the tumor more effectively than standard treatment.
Nanning, GuangxiAges 18 years+ - NCT06287814Recruiting
Blood test to detect leftover cancer DNA in colorectal cancer patients
This study uses a simple blood test (liquid biopsy) to look for tiny bits of tumor DNA remaining after colorectal cancer surgery. It aims to see if the test can help predict whether the cancer will come back, especially in people with stage III cancer who will receive chemotherapy.
Montpellier, HéraultAges 18 years+ - NCT06349642Recruiting
Testing a live tumor test for immune therapy response
This trial uses a special test on live tumor samples to see if it can predict how well immune checkpoint inhibitors (a type of immunotherapy) will work for different cancers. It may help doctors choose the best treatment for you.
Phoenix, ArizonaAges 18 years+ - NCT06368141RecruitingPhase 2
Chemo plus immunotherapy before surgery for colon cancer
This trial tests whether giving chemotherapy followed by an immunotherapy drug (a checkpoint inhibitor) before surgery helps shrink locally advanced colon cancer. It is for people with a specific tumor type (MSS and RAS mutation) who have not had prior treatment.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06490536RecruitingPhase 3
Testing a new treatment for high-risk colon cancer after surgery
This trial tests a new treatment approach for people with certain high-risk colon cancers (stage II or III in the upper colon) after surgery. It aims to see if adding a study drug can help prevent the cancer from coming back.
BerlinAges 18 years+ - NCT06609551RecruitingPhase 3
ctDNA-guided chemo choice for elderly colon cancer patients
This trial tests whether using a ctDNA blood test can help choose the best chemotherapy after colon cancer surgery for people aged 70–80. It aims to make treatment more personalized and reduce side effects.
Hangzhou, ZhejiangAges 70–80 - NCT06686576RecruitingPhase 3
Study of QL1706 before surgery for MSI-H colon cancer
This trial tests a new immunotherapy medicine (QL1706) given before surgery to treat colon cancer that hasn't spread yet. It's designed for patients whose tumors have a specific gene feature (MSI-H/dMMR) and who haven't had any prior treatment for this cancer.
GuangzhouAges 18–75 - NCT06746012Recruiting
Health app study for colorectal cancer survivors and their caregivers
This study tests a mobile health program to help colorectal cancer survivors and their family caregivers stick to healthy lifestyle habits. It's for survivors who are at least 6 months past treatment and have a smartphone.
Columbus, OhioAges 18 years+ - NCT06830239RecruitingPhase 2
Neoadjuvant dostarlimab for resectable stage III colon cancer
This trial tests an investigational immunotherapy drug called dostarlimab given before surgery for colon cancer. It is for people whose tumor is MMR-proficient (also called MSS) and is large enough or has spread to nearby lymph nodes but not to other parts of the body. The goal is to see if this treatment can shrink the tumor before surgery.
LeuvenAges 18 years+ - NCT06958926Recruiting
Study of colon cancer that returns after surgery
This study looks at colon cancer that comes back in the same area after surgery. It may help doctors understand how to better treat this type of recurrence.
HsinchuAges 18 years+ - NCT07140679RecruitingPhase 2
Immunotherapy after surgery for certain colon cancers
This trial tests whether the immunotherapy drug toripalimab can lower the risk of colon cancer coming back after surgery. It is for people with a specific genetic feature called mismatch repair deficiency (dMMR) in their tumor, and whose cancer was at a higher stage (stage IIB, IIC, or III).
Atlanta, GeorgiaAges 18 years+ - NCT07328087RecruitingEarly Phase 1
Personalized colon cancer vaccine trial for MSS stage 3 patients
This trial tests a custom-made vaccine designed from your tumor's genetic material. The vaccine is given alongside standard chemotherapy and an immunotherapy drug to try to prevent the cancer from coming back. It is for people with stage 3 colorectal cancer that has been fully removed by surgery and has certain high-risk features.
ThessalonikiAges Any age - NCT02172651RecruitingEarly Phase 1
Vitamin D during early colon cancer or liver surgery
This trial studies whether taking higher-dose vitamin D3 around the time of colon cancer (or colon cancer with resectable liver metastases) surgery improves outcomes. It focuses on safety and possible effects on cancer-related health after surgery.
Boston, MassachusettsAges 18 years+ - NCT07405476RecruitingPhase 2
Zanidatamab before surgery for HER2 positive colon or rectal cancer
This trial tests if the drug zanidatamab, given before surgery, can help treat colon or rectal cancer that has a specific marker called HER2. The goal is to see if this approach can shrink tumors and improve outcomes for people whose cancer has not spread to other parts of the body.
Atlanta, GeorgiaAges 18 years+ - NCT03976960Recruiting
Database study for colon cancer surgery patients
This study collects clinical and lab information from people who have surgery for colon cancer (or certain precancer growths) and related spread to organs. It may help researchers better understand colon cancer and improve future care, but it is not a new medication trial.
Montpellier, HéraultAges 18 years+ - NCT06010862RecruitingPhase 1
CAR-T therapy for CEA-positive advanced cancers
This trial tests a new type of immune cell therapy (called CAR-T) that targets a protein called CEA on cancer cells. It is for people with advanced colorectal, esophageal, stomach, or pancreatic cancer who have already tried standard treatments without success.
Nanchang, JiangxiAges 18 years+ - NCT06567782RecruitingPhase 2
Immunotherapy plus chemotherapy vs. chemotherapy alone for stage 3 colon cancer
This trial tests whether adding the immunotherapy drug dostarlimab to standard chemotherapy (CAPEOX) is more effective than chemotherapy alone for people with a specific type of colon cancer (MMRp/MSS) that has not spread. It is given before surgery to shrink the tumor.
AalstAges 18 years+
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Common questions
- Are there clinical trials for colon cancer stage iii?
- Yes. Clin2 currently lists 74 recruiting colon cancer stage iii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colon cancer stage iii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colon cancer stage iii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.