Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,214 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07263178Recruiting
Second-line chemo for advanced colorectal cancer
This study looks at different chemotherapy options for people with metastatic colorectal cancer that has stopped responding to first treatment. It aims to find which second-line approach works best.
SeoulAges 19 years+ - NCT07264556Recruiting
Comparing three anesthesia types for colorectal cancer surgery
This trial compares three types of anesthesia during colorectal cancer surgery to see how they affect the body's immune response and cancer cells. It may help find the safest and most effective anesthesia option for people having this operation for the first time.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07283575Recruiting
Blood test to monitor metastatic colorectal cancer treatment (PROMET)
This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA methylation) can help monitor how well treatment is working in people with colorectal cancer that has spread. If you are getting radiation and chemotherapy (with or without an immunotherapy drug), this trial may help your doctor see if the treatment is working sooner.
ShanghaiAges 18–75 - NCT07291180Recruiting
Personalized heated chemo for advanced appendix or colon cancer
This study tests a personalized way to deliver heated chemotherapy directly into the belly during surgery for advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if tailoring the chemo drugs to your tumor can improve outcomes.
New Haven, ConnecticutAges 18–81 - NCT07309289RecruitingPhase 3
Comparing two drug combos for first-line metastatic colorectal cancer
This trial tests whether a combination of chemotherapy drugs (NALIRIFOX) plus targeted therapy works better than another standard combination (FOLFOX) plus targeted therapy for people with metastatic colorectal cancer who haven't had treatment yet. It aims to find a more effective first treatment option.
ShanghaiAges 18 years+ - NCT07310446Recruiting
Blood test study for colorectal cancer detection
This study is collecting blood samples to improve a test that looks for signs of colorectal cancer in the blood. It may help find cancer earlier or better understand how to detect it.
Lake Barrington, IllinoisAges 45–84 - NCT07310537Recruiting
Liquid biopsy trial for colorectal cancer liver metastases
This study tests whether a simple blood sample from your finger can detect tumor DNA as well as a standard blood draw. It is designed for people with colorectal cancer that has spread to the liver and hasn't responded to treatment.
Rotterdam, South HollandAges 21 years+ - NCT07314294RecruitingPhase 2
Study of EMB-01 for advanced left-sided colorectal cancer
This trial tests a new drug, EMB-01, in people with advanced left-sided colorectal cancer that has spread or cannot be removed. It may help if standard treatments have stopped working or caused side effects.
BeijingAges 18 years+ - NCT07343791RecruitingEarly Phase 1
DC-CIK cell therapy plus three drugs for advanced colorectal cancer
This trial tests a combination of immune cells (DC-CIK) and three cancer drugs (epaloliposide, vortexil, and regorafenib) as a third-line treatment for people with advanced colorectal cancer that has spread. It aims to see if this mix is safe and helps shrink tumors or slow the cancer's growth.
Nanjing, JiangsuAges 18–75 - NCT07079631RecruitingPhase 1/Phase 2
Testing BNT314 with pumitamig and chemo for advanced colorectal cancer
This trial tests a new combination of drugs (BNT314 and pumitamig) plus chemotherapy for people with advanced colorectal cancer that has not responded to prior treatments. The goal is to see if this combination is safe and helps shrink or control the cancer.
New Haven, ConnecticutAges 18 years+ - NCT07349043RecruitingPhase 1
Spray chemotherapy for colon cancer spread in the belly
This trial tests a new way to give chemotherapy by spraying it into the belly during a minimally invasive surgery. It is for people whose colon or rectal cancer has spread inside the belly (peritoneal metastasis) but not to other organs.
Hangzhou, Other (Non U.s.)Ages 18–75 - NCT07353645RecruitingPhase 1/Phase 2
KRAS vaccine for colorectal and pancreatic cancer after surgery
This trial tests a new vaccine that targets KRAS mutations in patients with colorectal or pancreatic cancer after surgery and chemotherapy. The goal is to see if the vaccine can help prevent the cancer from coming back.
Nanjing, JiangsuAges 18–75 - NCT07361003RecruitingPhase 3
Testing suvemcitug plus chemo for refractory colorectal cancer
This trial tests a new drug, suvemcitug, combined with an oral chemotherapy called FTD/TPI for people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
Fuzhou, FujianAges 18 years+ - NCT07361107RecruitingPhase 1
Immune response study of histotripsy in colorectal cancer
This trial tests how your body's immune system reacts to a treatment called histotripsy for colorectal cancer that has spread to the liver. Histotripsy uses sound waves to break apart tumors, and the study aims to see if this can help your immune system fight the cancer better.
New Hyde Park, New YorkAges 18 years+ - NCT07365527Recruiting
Ultrasound and Tumor Response in Colorectal Liver Metastases
This study is testing a new way to use ultrasound to help treat colorectal cancer that has spread to the liver. It may help doctors see how tumors respond to treatment.
CopenhagenAges 18 years+ - NCT07371832Recruiting
AI Stapler vs. Standard Stapler for Colorectal Cancer Surgery
This trial compares a new AI-assisted robotic stapler to a standard stapler used during surgery for colorectal cancer that has not spread. The goal is to see if the new stapler is safer and works better.
Hyderabad, TelanganaAges 18–80 - NCT07389265RecruitingPhase 3
Continuing cetuximab after first treatment stops working for metastatic colorectal cancer
This trial tests if continuing the targeted therapy cetuximab after initial treatment stops working can help people with advanced colorectal cancer. Participants have a specific gene profile (RAS and BRAF normal) and their cancer responds well at first.
AnconaAges 18 years+ - NCT00899626Recruiting
Collecting stool and tissue markers from people with bowel conditions
This study collects samples (like tissue and other body fluids) from people who are getting a colonoscopy or similar camera test. It aims to find “biomarkers,” which are measurable signals that may help doctors better understand or detect bowel problems such as colorectal cancer, polyps, or inflammatory bowel disease.
Nashville, TennesseeAges 18 years+ - NCT01762813Recruiting
Study of blood/tissue markers in colorectal cancer surgery patients
This study looks at colorectal cancer patients who are planning curative surgery and collects related outcomes and lab “biomarker” information to better understand the disease. Your participation may help researchers connect test results to treatment results over time.
StavangerAges 18 years+ - NCT01479608Recruiting
Liver transplant for colon or rectal cancer liver spread
This trial studies whether a liver transplant can help people with colon or rectal cancer that has spread to the liver (but not elsewhere). It aims to improve outcomes by removing the diseased liver when the cancer has responded to chemotherapy and can still be controlled.
OsloAges 18 years+ - NCT02732860Recruiting
Test your tumor’s drug response using a lab model
This trial grows a lab model from your own tumor tissue (or resected tissue) to predict which drugs might work best. It’s meant to match investigational treatments to your specific tumor biology.
Toronto, OntarioAges 18 years+ - NCT02328677Recruiting
Colorectal cancer study for newly diagnosed patients
This study enrolls people newly diagnosed with colon or rectal cancer to learn about their care and outcomes. You might be able to join if you meet the age, language, and consent requirements.
Los Angeles, CaliforniaAges 18–89 - NCT02864485Recruiting
Living donor liver transplant for colorectal cancer spread to the liver
This trial looks at whether a living-donor liver transplant can help people with colorectal cancer that has spread to the liver but cannot be surgically removed. It focuses on people whose cancer has not worsened on prior chemotherapy and who are medically able to undergo a major liver surgery.
Toronto, OntarioAges 18–68 - NCT02246634Recruiting
MRI screening to find liver metastases in bowel cancer
This study checks whether a special MRI scan (DW-MRI) can spot liver metastases early in people with high-risk colorectal cancer. Finding metastases sooner may help doctors choose the right treatment path.
Macclesfield, CheshireAges 16 years+
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,214 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.