Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06184594Enrolling by invitation
Using eNav Toolkit to boost colon cancer screening
This trial tests a computer program (eNav Toolkit) to help people decide about colon cancer screening. If you are between 45 and 75 and due for screening, this study may help you make an informed choice.
New York, New YorkAges 45–75 - NCT06193356Recruiting
Can endoscopists learn to spot scar after polyp removal?
This study tests whether endoscopists can learn to see scarring and find any remaining tissue after polyp removal. It may help improve how doctors check for cancer coming back.
GhentAges 18 years+ - NCT06205836RecruitingPhase 2
Cemiplimab with or without Fianlimab for MSI-H Colorectal Cancer in Older Patients
This trial tests a new immunotherapy combination for older patients with a specific type of colorectal cancer that has not been treated before. The goal is to see if these drugs can help the immune system fight the cancer without needing surgery or standard chemotherapy.
Baltimore, MarylandAges 18 years+ - NCT06149481RecruitingPhase 1/Phase 2
STAR15 immunotherapy for metastatic colorectal cancer
This trial tests a combination of four drugs (SX-682, TriAdeno vaccine, retifanlimab, and N-803) to see if they can help people with colorectal cancer that has spread. It may be an option if you have already tried at least two standard treatments or cannot take them.
Bethesda, MarylandAges 18–120 - NCT06130280RecruitingPhase 2
MRI-guided radiation for liver tumors from colorectal cancer
This trial tests a single, high-dose radiation treatment (SBRT) guided by MRI for people with colorectal cancer that has spread to the liver. The goal is to see if this precise, one-time treatment can effectively control liver tumors while protecting nearby organs.
Basking Ridge, New JerseyAges 18 years+ - NCT06154538RecruitingPhase 2
Immunotherapy plus chemo vs. chemo alone for advanced colorectal cancer before surgery
This trial tests whether adding immunotherapy (a treatment that helps your immune system fight cancer) to standard chemotherapy before surgery works better than chemotherapy alone for people with locally advanced colorectal cancer.
Beijing, Beijing MunicipalityAges 18–75 - NCT06111105Recruiting
Comparing blood tests to guide colon cancer treatment
This study compares different blood tests to find the best way to detect tiny bits of cancer DNA after surgery for stage III colorectal cancer. It aims to help doctors decide if additional chemotherapy is needed to prevent the cancer from coming back.
Graz, StyriaAges 18 years+ - NCT06098560Recruiting
ctDNA as a marker for immunotherapy in advanced colorectal cancer
This study looks at whether a blood test for tumor DNA (ctDNA) can predict how well immunotherapy works in people with advanced or locally advanced colorectal cancer that has specific genetic features (dMMR/MSI-H). If you qualify, the trial will monitor your ctDNA levels while you receive standard immunotherapy to see if changes in those levels can show early on if the treatment is working.
Beijing, Beijing MunicipalityAges 18–80 - NCT06085560Enrolling by invitation
Choose and use an at-home colorectal cancer screening test
This study helps African American adults choose an at-home colorectal cancer screening test and make a plan to use it. It aims to make screening easier and more convenient for you.
Flint, MichiganAges 45–72 - NCT06096688Recruiting
Finding new ways to lower colorectal and endometrial cancer risk
This study looks for new ways to lower the risk of colorectal and endometrial cancers. It collects tissue and information from people who are getting certain procedures or treatments at Weill Cornell Medicine.
New York, New YorkAges 18 years+ - NCT06074536Recruiting
Training doctors to share decisions in colorectal cancer screening
This study tests whether training doctors to better involve patients in decisions about colorectal cancer screening improves shared decision-making. If you are between 50 and 74 and due for screening, your GP might invite you to join.
Soisy-sous-MontmorencyAges 50–74 - NCT06051695RecruitingPhase 1/Phase 2
CAR T cell therapy for mesothelin-positive solid tumors
This trial tests a new type of immune cell therapy (CAR T-cells) designed to target cancer cells that have a protein called mesothelin but have lost a marker that lets them hide from the immune system. It's for people with advanced solid tumors who have already tried standard treatments.
Gilbert, ArizonaAges 18 years+ - NCT06012734RecruitingPhase 1
LB-100 plus Atezolizumab for metastatic colorectal cancer
This trial tests a new two-drug combination (LB-100 plus atezolizumab) for people with metastatic colorectal cancer that hasn't responded to standard treatment. The goal is to see if the combination can help shrink or slow the cancer.
Amsterdam, North HollandAges 18 years+ - NCT06008119RecruitingPhase 3
Targeted pill combination for BRAF-mutated metastatic colorectal cancer
This study tests a combination of two targeted pills (tunlametinib and vemurafenib) for people with metastatic colorectal cancer that has a specific gene change (BRAF V600E) and whose cancer has grown after at least one prior treatment. The goal is to see if this drug combination can shrink tumors or slow cancer growth.
Beijing, Beijing MunicipalityAges 18–70 - NCT05985954RecruitingPhase 1
Ulixertinib with cetuximab for colorectal cancer
This trial tests whether the drug ulixertinib, combined with cetuximab (and sometimes encorafenib), can help people with advanced or metastatic colorectal cancer who have already tried EGFR or BRAF-targeted therapy. It aims to find new treatment options for these patients.
Houston, TexasAges 18 years+ - NCT05984589Recruiting
Personal health coaching for colorectal cancer survivors
This study tests a personalized health coaching program to help colorectal cancer survivors improve their lifestyle habits, such as diet and physical activity, which may improve their health and well-being.
Los Angeles, CaliforniaAges 18 years+ - NCT05993923Recruiting
Geriatric team support for seniors having colorectal cancer surgery
This study tests whether a team of specialists (including a geriatric doctor) can help people aged 70+ recover better after colorectal cancer surgery. The goal is to see if this approach improves your daily functioning and independence after the operation.
Nîmes, FranceAges 70 years+ - NCT03926338RecruitingPhase 2
Before-surgery immunotherapy for MSI-H or dMMR colon cancer
This trial studies a treatment given before surgery using toripalimab, with or without celecoxib, for colon or rectal cancer that has MSI-H or dMMR tumor features. It aims to shrink or control the cancer before the operation and compare whether adding celecoxib helps.
Guangzhou, GuangdongAges 18–75 - NCT05954429RecruitingPhase 2
Study of fruquintinib plus immunotherapy after standard CRC treatment
This trial studies fruquintinib combined with serplulimab (an immune therapy) for advanced colorectal cancer that has spread and is no longer responding to standard treatments. It may help by slowing the cancer’s growth and improving outcomes after the usual options have been tried.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05959356RecruitingPhase 2
First-line treatment for left-sided metastatic colon cancer with specific tumor markers
This Phase 2 trial tests a combination of medicines (cetuximab, envafolimab, and chemotherapy) as the first treatment for certain left-sided metastatic colorectal cancers. It may help by slowing or shrinking the cancer in people whose tumor has no RAS/BRAF mutations and is microsatellite-stable (MSS).
Foshan, GuangdongAges 18 years+ - NCT05947838Recruiting
Blood test helps choose chemotherapy before colorectal or appendix surgery
This study uses a blood test called ctDNA to help tailor (personalize) neoadjuvant chemotherapy for people with colorectal or appendix cancer before surgery. The goal is to see if using ctDNA can help doctors pick the most appropriate chemotherapy plan for you.
Houston, TexasAges 18 years+ - NCT05051046Recruiting
Screening colonoscopy with hypnosis for colorectal cancer
This trial studies whether using hypnosis during a screening colonoscopy can help people better tolerate the procedure and complete it comfortably. It’s for adults who are scheduled for a routine screening colonoscopy and meet specific safety and communication requirements.
AngersAges 18–100 - NCT05854498RecruitingPhase 2
Study drug combination for metastatic colon cancer with prior treatments
This Phase 2 trial tests a chemotherapy combination (liposomal irinotecan), along with TAS-102 and bevacizumab, in people with metastatic colon cancer. It may help if your tumor has mismatch repair–proficient features and you’ve already tried standard colon cancer drugs.
Madison, WisconsinAges 18 years+ - NCT05877456Enrolling by invitation
Checking a polyp-removal scoring tool for doctors
This study tests and confirms a scoring tool (GPAT) that helps describe how well doctors perform polyp removal during endoscopy. It may help standardize training and assessment, which can improve consistency in care.
Ghent, GentAges 18–100
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,202 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.