Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04767568Recruiting
Testing a blood test to guide colorectal cancer screening care
This study looks at whether a simple blood test can help guide the care of people being evaluated for colorectal cancer. It may support earlier or clearer decision-making alongside existing screening or colonoscopy results.
BesançonAges 18 years+ - NCT04296630Enrolling by invitation
Social media for colorectal cancer screening
This study looks at whether social media messages can encourage people in Ontario to get screened for colorectal cancer. If you use Facebook and are in the right age range, you may be able to take part.
Toronto, OntarioAges 55–64 - NCT04236128Recruiting
Mobile app support after colorectal surgery at home
This trial studies a home mobile app to help people after elective colorectal surgery transition safely back home. It may help you feel more supported with recovery and instructions once you’re discharged.
Toronto, OntarioAges 18 years+ - NCT03965234RecruitingPhase 1/Phase 2
Lung infusion for colorectal cancer that has spread to the lungs
This trial tests a procedure where chemotherapy is delivered directly into the lungs during surgery to remove or destroy lung tumors. It aims to reduce the chance of cancer returning after surgery for people with colorectal cancer that has spread to the lungs.
Buffalo, New YorkAges 18 years+ - NCT03998202Recruiting
Study of chemotherapy side effects in older colorectal cancer patients
This study looks at how chemotherapy and immunotherapy affect the body in older adults with colorectal cancer, especially early side effects. It may help researchers understand why some people lose strength and how to better predict and manage treatment toxicity.
Millville, DelawareAges 60 years+ - NCT03841799Recruiting
Study of gut bacteria and immune changes in colon tissue
This study looks at how gut bacteria and immune activity differ in normal, pre-cancer, and cancer colon tissue. It may help researchers understand what changes in the body are linked to colon growth and how they could be targeted in the future.
Lyon, LyonAges 18 years+ - NCT03793335Enrolling by invitation
Personalized prevention plan for stomach and colon cancer in the community
This trial tests personalized prevention strategies to help lower the risk of stomach (gastric) and colon (colorectal) cancer in community members. It may help by tailoring screening and prevention steps to your individual health and risk factors.
TaipeiAges 50–75 - NCT02997293Recruiting
Enhanced recovery after colorectal surgery care program
This study looks at whether a structured “enhanced recovery” plan around the time of colorectal surgery improves outcomes. Because it focuses on a specific group of surgeries done at a specific hospital during certain dates, it may be mainly for people whose surgeries match those records.
Little Rock, ArkansasAges 18 years+ - NCT02732860Recruiting
Test your tumor’s drug response using a lab model
This trial grows a lab model from your own tumor tissue (or resected tissue) to predict which drugs might work best. It’s meant to match investigational treatments to your specific tumor biology.
Toronto, OntarioAges 18 years+ - NCT02863172Recruiting
Genetic studies in families with inherited colon cancer
This study looks at genetic reasons some families get colon cancer due to inherited (run-in-the-family) syndromes. It may help doctors better understand risk and tailor care for you or your relatives.
Houston, TexasAges 18 years+ - NCT01762813Recruiting
Study of blood/tissue markers in colorectal cancer surgery patients
This study looks at colorectal cancer patients who are planning curative surgery and collects related outcomes and lab “biomarker” information to better understand the disease. Your participation may help researchers connect test results to treatment results over time.
StavangerAges 18 years+ - NCT00899626Recruiting
Collecting stool and tissue markers from people with bowel conditions
This study collects samples (like tissue and other body fluids) from people who are getting a colonoscopy or similar camera test. It aims to find “biomarkers,” which are measurable signals that may help doctors better understand or detect bowel problems such as colorectal cancer, polyps, or inflammatory bowel disease.
Nashville, TennesseeAges 18 years+ - NCT07873450RecruitingPhase 1/Phase 2
Study of a new treatment for advanced cancers with c-MET protein
This study tests a new radioactive treatment for people with advanced solid tumors, such as certain lung, colon, head and neck, or bile duct cancers, that have stopped responding to standard treatments. The treatment targets a protein called c-MET found on cancer cells, aiming to deliver radiation directly to the tumor.
NedlandsAges 18 years+ - NCT07328516Enrolling by invitation
Farm childhood health study for adult children
This study looks at how early-life exposures on farms might influence long-term health. If you are an adult child of a farmer or farmworker from the Agricultural Health Study, and you spent time on a farm as a child, you may be able to join.
Bethesda, MarylandAges 18–99 - NCT07807956RecruitingPhase 1
Intravenous study drug for advanced solid tumors
This trial tests an investigational drug given through an IV to see if it can help people with advanced solid tumors. It aims to learn about side effects, how the drug works in the body, and whether it can slow or shrink the cancer.
Grand Rapids, MichiganAges 18 years+ - NCT07448142RecruitingPhase 2
Low-dose radiation with immunotherapy and chemo for advanced rectal cancer
This trial tests a combination of low-dose radiation, an immunotherapy drug called pucotenlimab, and chemotherapy for locally advanced rectal cancer that has not spread. The goal is to see if adding radiation helps shrink the tumor more effectively before surgery.
Guangzhou, GuanggongAges 18–75 - NCT07875829Recruiting
Recovery after colorectal surgery: Robots vs laparoscopic
This study compares how quickly and how well people recover after surgery to remove part of the colon or rectum, using either a robotic or a laparoscopic (keyhole) approach. Both are minimally invasive, but this trial aims to see if one leads to a smoother and faster recovery.
Funchal, MadeiraAges 18 years+ - NCT07458347RecruitingPhase 1
Study of a new drug for advanced solid tumors with a KRAS mutation
This trial tests a new pill, KST-6051, for people with advanced solid tumors (like lung, pancreatic, or colorectal cancer) that have a specific genetic change called a KRAS mutation. The goal is to see if the drug can shrink or control the cancer, and to find the best dose.
Los Angeles, CaliforniaAges 18 years+ - NCT07020221RecruitingPhase 1/Phase 2
Study of VS-7375 for cancers with a KRAS G12D mutation
This study tests an experimental drug called VS-7375 for people with advanced solid tumors that have a specific genetic change called KRAS G12D. The goal is to see if the drug can shrink tumors or slow their growth.
Los Angeles, CaliforniaAges 18 years+ - NCT02917707Recruiting
Study for colon cancer that has spread to the liver
This study focuses on people with colon cancer (CRC) that has spread to the liver. It looks at factors that may affect liver metastases and could help doctors better understand who may benefit from future treatments.
Ganzhou, JiangxiAges 18–75 - NCT03925662RecruitingPhase 3
Mebendazole added to stage 4 colon cancer care
This trial studies whether adding mebendazole (an existing anti-parasite medicine) to standard treatment can improve outcomes for people with stage 4 colon cancer. You might qualify if you have stage 4 colorectal cancer and none of the key safety concerns.
CairoAges 18 years+ - NCT03692429RecruitingPhase 1
Testing new immune cells plus chemo for advanced colon cancer
This Phase 1 study tests CYAD-101, an immune-cell treatment made from donor T-cells, given with standard chemotherapy. It is for people with colon or rectal cancer that has spread and has not responded to prior treatments.
Tampa, FloridaAges 18 years+ - NCT03787056Recruiting
Blood test marker study in many cancer types
This study measures a blood marker called progastrin (at diagnosis and during treatment) to see how well it predicts response or outcomes. It may help doctors choose or monitor treatment more precisely for several cancer types.
BronAges 18 years+ - NCT02073500Recruiting
Study of treatments and models for cancer in the belly lining
This study looks at how cancers that spread along the belly lining (“peritoneal surface malignancies”) behave and how different treatment strategies may work. It may help improve how doctors select and test treatments for people who are candidates for CRS-HIPEC, a specific cancer surgery approach.
OsloAges 18 years+
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,202 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.