Clinical trials · North Carolina
COPD clinical trials in North Carolina
We’re tracking 25 recruiting copd studies with a site in North Carolina — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT07816835RecruitingPhase 4
Comparing nebulizer vs inhaler for COPD treatment
This study compares two ways of taking COPD maintenance medicines: using a nebulizer vs. using a handheld inhaler. The goal is to see which method works better for people with severe COPD, so researchers can help guide treatment choices.
Winston-Salem, North CarolinaAges 60 years+ - NCT07612878Recruiting
Registry tracking COPD patients starting dupilumab treatment
This is a registry—an observational study tracking patients with COPD (chronic lung disease) who are newly starting a medication called dupilumab. Researchers will follow your health outcomes to learn how well this treatment works in real-world practice.
Durham, North CarolinaAges 40 years+ - NCT07684820RecruitingPhase 2
A study of ExPD-101 for COPD with chronic bronchitis and frequent flare-ups
This study tests an experimental drug (ExPD-101) given daily as a pill for 52 weeks for people with COPD who have chronic bronchitis and frequent flare-ups. It compares the drug to a placebo (inactive pill) to see if it reduces flare-ups and improves symptoms.
Shelby, North CarolinaAges 40–85 - NCT07646587RecruitingPhase 2
Safety Study of WIN378 for Moderate-Severe COPD
This study tests a new drug called WIN378 in people with moderate-to-severe COPD (chronic lung disease). It will check if the drug is safe and how the body processes it, which may help improve breathing and reduce flare-ups.
Charlotte, North CarolinaAges 40–80 - NCT07059091RecruitingPhase 2
Allergy medicine for COPD with indoor allergies
This study tests if omalizumab, an allergy medicine, can help people with COPD who are allergic to common indoor allergens and have had recent flare-ups. It aims to see if reducing allergic reactions can improve COPD control.
Durham, North CarolinaAges 40 years+ - NCT07051707Recruiting
Study of a new lung treatment for people with COPD
This trial tests a device called dNerva that targets nerves in the lungs to help people with COPD breathe easier. It is designed for those who have moderate to severe COPD and are not currently smoking.
Salem, North CarolinaAges 40–80 - NCT07037836RecruitingPhase 2
Inhaled treprostinil for COPD with low oxygen
This trial tests an inhaled medication called treprostinil (Tyvaso) to see if it can help people with COPD who have low blood oxygen levels. You may qualify if you have chronic bronchitis, use oxygen at rest or during exercise, and meet specific lung function criteria.
Durham, North CarolinaAges 40 years+ - NCT06883305RecruitingPhase 3
Testing tezepelumab for moderate to severe COPD
This trial tests tezepelumab, an injected medication, for people with moderate to very severe COPD who still have flare-ups despite using standard inhalers. It may help reduce flare-ups and improve breathing for those with higher eosinophil levels.
Wilmington, North CarolinaAges 40–80 - NCT06878261RecruitingPhase 3
Tezepelumab for moderate to very severe COPD
This study tests a new medication called tezepelumab (given as a shot) to see if it can reduce COPD flare-ups in people with moderate to very severe COPD who have had recent flare-ups despite using inhalers. It may be an option for those with higher levels of eosinophils (a type of white blood cell) in their blood.
Charlotte, North CarolinaAges 40–80 - NCT05033990Recruiting
Study of early COPD changes using breathing tests and scans
This study follows people with early COPD patterns (or no lung disease) to understand how COPD starts and progresses over time. You may have breathing tests and possibly CT scans, and some participants may join an added lung procedure (bronchoscopy).
Winston-Salem, North CarolinaAges 30–55 - NCT07610395RecruitingPhase 2
Testing an oral drug for cold virus in COPD patients
This trial tests an oral medication (VPV) to see if it can safely treat rhinovirus (a common cold virus) in people with COPD. The goal is to help you recover faster and prevent serious COPD flare-ups.
Kings Mountain, North CarolinaAges 40–85 - NCT07838519Enrolling by invitation
Personalized lung cancer screening for veterans
This study tests a personalized approach to help veterans decide if lung cancer screening is right for them. It aims to improve early detection by considering each person's unique risk factors, such as smoking history, military exposures, and lung health.
Salisbury, North CarolinaAges 50–80 - NCT07190209RecruitingPhase 3
Testing lunsekimig for COPD with frequent flare-ups
This trial tests a new medicine called lunsekimig for people with COPD that still causes flare-ups despite standard treatment. It focuses on people with higher blood eosinophils (a type of white blood cell). If you smoke or used to smoke and have had at least 2 moderate or 1 severe flare-up in the past year, this study may be an option.
Durham, North CarolinaAges 40–80 - NCT07190222RecruitingPhase 3
New medicine for COPD with frequent flare-ups
This study tests a new medicine called Lunsekimig for people with COPD that has frequent flare-ups and high eosinophil levels (a sign of inflammation). It aims to see if it can help control symptoms better than a placebo (a dummy treatment).
Greenville, North CarolinaAges 40–80 - NCT07177339RecruitingPhase 3
Testing depemokimab for COPD with type 2 inflammation
This study tests an early treatment called depemokimab for people with moderate to severe COPD who have a type of inflammation linked to high eosinophils. It aims to reduce flare-ups and improve breathing.
Winston-Salem, North CarolinaAges 40–75 - NCT07082738RecruitingPhase 2
Study of AZD6793 for people with moderate to very severe COPD
This trial tests a new drug called AZD6793 for people with moderate to very severe COPD. It aims to see if the drug can help improve breathing and reduce flare-ups.
New Bern, North CarolinaAges 40 years+ - NCT07031336Recruiting
Photon-counting CT for better lung scans
This trial is testing a new type of CT scanner (photon-counting CT) for chest imaging. If you are already in the Duke-COPDGene study, you may be invited to also get this special scan to see if it gives clearer pictures of your lungs.
Durham, North CarolinaAges Any age - NCT06959095RecruitingPhase 3
Depemokimab for adults with COPD and type 2 inflammation
This trial tests a new biologic medicine called depemokimab, given as an injection, to see if it reduces flare-ups (exacerbations) in people with COPD who have a specific type of inflammation (high eosinophils). It may help if you have frequent flare-ups despite using your regular inhalers.
Winston-Salem, North CarolinaAges 40–80 - NCT06961214RecruitingPhase 3
Depemokimab for COPD with type 2 inflammation
This study tests a new biologic medicine, given as an injection, to see if it can reduce flare-ups in adults with COPD who have a certain type of inflammation. It may help people who still have frequent exacerbations despite using their current inhalers.
Shelby, North CarolinaAges 40–80 - NCT06283966RecruitingPhase 3
Triple inhaler for COPD with heart risk
This study tests a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) to see if it can help protect the heart and lungs in people with COPD who also have heart problems or high risk for them.
Fayetteville, North CarolinaAges 40–80 - NCT05879211Enrolling by invitation
Care learning lab for Duke Health patients
This trial is a “learning laboratory” that studies how best to provide goal-focused care. It may help improve care experiences for Duke Health patients, based on what the study learns.
Durham, North CarolinaAges 18 years+ - NCT05696782RecruitingPhase 2
Durvalumab after chemoradiation for stage III lung cancer
This trial tests giving durvalumab (an immune therapy) soon after standard chemotherapy and radiation for stage II–III non-small cell lung cancer that cannot be removed by surgery. The goal is to see if this “quick start” approach improves outcomes compared with waiting longer to begin durvalumab.
Charlotte, North CarolinaAges 18 years+ - NCT04930289Enrolling by invitation
Lung transplant registry for better donor lung preservation
This study builds a worldwide database to track and improve how donor lungs are preserved before transplant. Your information may help doctors choose and manage donor lungs more effectively.
Durham, North CarolinaAges Any age - NCT04778046RecruitingPhase 2
Study lung pressure treatment for people waiting for transplant
This Phase 2 trial is for adults with pulmonary hypertension who are on the lung transplant waiting list at Duke. It aims to test whether the study treatment can improve lung pressure and related health outcomes, while using things like MRI to monitor changes.
Durham, North CarolinaAges 18 years+
COPD trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting copd studies listed above.
- Research Site · 4 studies
- Duke University Medical Center · 3 studies
- GSK Investigational Site · 3 studies
- Atrium Health Wake Forest Baptist · 2 studies
- Duke University Health System · 2 studies
- Advanced Respiratory and Sleep Medicine - Hickory- Site Number : 8400013
- Atrium Health Levine Cancer Institute
- Atrium Health Wake Forest Baptist Pulmonary, Sleep And Allergy- Site Number : 8400048
What taking part in a copd study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
COPD trials in other states
Common questions
- Are there copd clinical trials in North Carolina?
- Yes. We're currently tracking 25 recruiting copd studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a copd study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a copd trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New copd studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.